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Study · Animal study (in vivo) · rat · 2017

7 results

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD.

Szeto HH, Liu S, Soong Y, Seshan SV, Cohen-Gould L, Manichev V, Feldman LC, Gustafsson T

Journal of the American Society of Nephrology : JASN23 Nov 2016Cited by 151 (Europe PMC)

PMID27881606 (opens in a new tab)PMCIDPMC5407729 (opens in a new tab)DOI10.1681/asn.2016070761 (opens in a new tab)PepBankPUB-27881606
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with chronic kidney disease after renal ischemia, SS‑31 started one month after ischemia preserved mitochondrial integrity.

    In plain wordsIn rats with kidney damage after ischemia, SS‑31 treatment kept the energy-producing parts of cells (mitochondria) intact.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial integrity
    Study

    ratn: not reported in source

    Sprague-Dawley rats, 45 minutes of bilateral renal ischemia, chronic kidney disease
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment with a mitoprotective agent (SS-31; elamipretide) for 6 weeks, starting 1 month after ischemia, preserved mitochondrial integrity
    1 context sentence
    Summary · context
    We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with chronic kidney disease after renal ischemia, SS‑31 ameliorated the expression levels of all inflammatory markers.

    In plain wordsIn rats with kidney damage after ischemia, SS‑31 treatment reduced the levels of the inflammation markers that were measured.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal expression of inflammatory markers
    Study

    ratn: not reported in source

    Sprague-Dawley rats, 45 minutes of bilateral renal ischemia, chronic kidney disease
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    ameliorated expression levels of all inflammatory markers
    2 context sentences
    Summary · context
    Treatment with a mitoprotective agent (SS-31; elamipretide) for 6 weeks, starting 1 month after ischemia, preserved mitochondrial integrity
    Summary · context
    We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic kidney disease after renal ischemia, SS‑31 restored glomerular capillaries and podocyte structure.

    In plain wordsIn rats with kidney damage after ischemia, SS‑31 treatment restored the kidney's small blood vessels and filter cells (podocytes).

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGlomerular capillaries and podocyte structure
    Study

    ratn: not reported in source

    Sprague-Dawley rats, 45 minutes of bilateral renal ischemia, chronic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    restored glomerular capillaries and podocyte structure
    2 context sentences
    Summary · context
    Treatment with a mitoprotective agent (SS-31; elamipretide) for 6 weeks, starting 1 month after ischemia, preserved mitochondrial integrity
    Summary · context
    We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic kidney disease after renal ischemia, SS‑31 arrested the progression of glomerulosclerosis.

    In plain wordsIn rats with kidney damage after ischemia, SS‑31 treatment stopped scarring of the kidney filters (glomerulosclerosis) from getting worse.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGlomerulosclerosis
    Study

    ratn: not reported in source

    Sprague-Dawley rats, 45 minutes of bilateral renal ischemia, chronic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    arrested glomerulosclerosis and interstitial fibrosis.
    2 context sentences
    Summary · context
    Treatment with a mitoprotective agent (SS-31; elamipretide) for 6 weeks, starting 1 month after ischemia, preserved mitochondrial integrity
    Summary · context
    We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic kidney disease after renal ischemia, SS‑31 arrested the progression of interstitial fibrosis.

    In plain wordsIn rats with kidney damage after ischemia, SS‑31 treatment stopped scarring of kidney tissue (interstitial fibrosis) from getting worse.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInterstitial fibrosis
    Study

    ratn: not reported in source

    Sprague-Dawley rats, 45 minutes of bilateral renal ischemia, chronic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    arrested glomerulosclerosis and interstitial fibrosis.
    2 context sentences
    Summary · context
    Treatment with a mitoprotective agent (SS-31; elamipretide) for 6 weeks, starting 1 month after ischemia, preserved mitochondrial integrity
    Summary · context
    We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with chronic kidney disease after renal ischemia, helium ion microscopy showed that SS‑31 restored podocyte structure.

    In plain wordsIn rats with kidney damage after ischemia, high-resolution imaging showed that SS‑31 treatment restored the structure of kidney filter cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreasePodocyte structure by helium ion microscopy
    Study

    ratn: not reported in source

    Sprague-Dawley rats, 45 minutes of bilateral renal ischemia, chronic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Further, helium ion microscopy vividly demonstrated the restoration of podocyte structure by SS-31.
    1 context sentence
    Summary · context
    We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic kidney disease after renal ischemia, the protection by SS‑31 lasted at least 6 months after treatment ended, with normalization of IL-18 and IL-1β expression.

    In plain wordsIn rats with kidney damage after ischemia, SS‑31 protection lasted at least 6 months after treatment stopped, and inflammation markers returned to normal levels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePersistence of protection and IL-18 and IL-1β expression after treatment ended
    Study

    ratn: not reported in source

    Sprague-Dawley rats, 45 minutes of bilateral renal ischemia, chronic kidney disease
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    The protection by SS-31 was sustained for ≥6 months after treatment ended, with normalization of IL-18 and IL-1β expression.
    1 context sentence
    Summary · context
    We conducted a 9-month study in Sprague-Dawley rats after 45 minutes of bilateral renal ischemia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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