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Study · Animal study (in vivo) · pig · 2014

9 results

Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease.

Eirin A, Ebrahimi B, Zhang X, Zhu XY, Woollard JR, He Q, Textor SC, Lerman A, Lerman LO

Cardiovascular research19 Jun 2014Cited by 102 (Europe PMC)

PMID24947415 (opens in a new tab)PMCIDPMC4155472 (opens in a new tab)DOI10.1093/cvr/cvu157 (opens in a new tab)PepBankPUB-24947415
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In pigs with atherosclerotic renovascular disease, Bendavia restored renal cardiolipin content.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia restored the mitochondrial lipid cardiolipin in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal cardiolipin content
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Source sentences

    Summary
    Bendavia restored cardiolipin content in ARVD
    1 context sentence
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with atherosclerotic renovascular disease, Bendavia improved renal vascular density.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia improved the density of small blood vessels in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal microvascular density
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Source sentences

    Summary
    improved vascular density
    1 context sentence
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with atherosclerotic renovascular disease, Bendavia improved renal oxygenation.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia improved oxygen levels in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal oxygenation
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Source sentences

    Summary
    improved vascular density, oxygenation
    1 context sentence
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with atherosclerotic renovascular disease, Bendavia improved stenotic-kidney renal blood flow, which had decreased in vehicle-treated ARVD pigs.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia improved blood flow in the affected kidney compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseStenotic-kidney renal blood flow (RBF)
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Measurements

    RBF
    535.1 mL/min
    ARVD + Bendavia

    Source sentences

    Summary
    improved vascular density, oxygenation, RBF (535.1 ± 24.9 mL/min)
    2 context sentences
    Summary · context
    Stenotic-kidney renal blood flow (RBF) and glomerular filtration rate (GFR) decreased in ARVD + Vehicle compared with normal (318.8 ± 61.0 vs. 553.8 ± 82.8 mL/min and 48.0 ± 4.0 vs. 84.0 ± 3.8 mL/min, respectively) associated with loss of cardiolipin, intra-renal microvascular rarefaction, and hypoxia.
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with atherosclerotic renovascular disease, Bendavia improved stenotic-kidney glomerular filtration rate, which had decreased in vehicle-treated ARVD pigs.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia improved the filtering function of the affected kidney compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseStenotic-kidney glomerular filtration rate (GFR)
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Measurements

    GFR
    86.6 mL/min
    ARVD + Bendavia

    Source sentences

    Summary
    GFR (86.6 ± 11.2 mL/min).
    2 context sentences
    Summary · context
    Stenotic-kidney renal blood flow (RBF) and glomerular filtration rate (GFR) decreased in ARVD + Vehicle compared with normal (318.8 ± 61.0 vs. 553.8 ± 82.8 mL/min and 48.0 ± 4.0 vs. 84.0 ± 3.8 mL/min, respectively) associated with loss of cardiolipin, intra-renal microvascular rarefaction, and hypoxia.
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In pigs with atherosclerotic renovascular disease, Bendavia ameliorated renal oxidative stress.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia reduced oxidative stress in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal oxidative stress
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Source sentences

    Summary
    Oxidative stress and fibrosis were ameliorated
    1 context sentence
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with atherosclerotic renovascular disease, Bendavia ameliorated renal fibrosis.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia reduced scarring in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal fibrosis
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Source sentences

    Summary
    Oxidative stress and fibrosis were ameliorated
    1 context sentence
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with atherosclerotic renovascular disease, Bendavia normalized renovascular endothelial function in vivo.

    In plain wordsIn pigs with narrowed kidney arteries, Bendavia returned the function of kidney blood vessel lining to normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenovascular endothelial function in vivo
    Study

    pign: not reported in source

    Swine with atherosclerotic renovascular disease (ARVD)
    Comparator
    ARVD + vehicle
    Outcome group
    Kidney function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · last 4 weeks of a 10-week ARVD periodAs given in this study (pig).

    Source sentences

    Summary
    renovascular endothelial function normalized both in vivo and in vitro.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 10 weeks of ARVD or sham, treated for the last 4 weeks with daily subcutaneous injections (5 days/week) of vehicle or Bendavia (0.1 mg/kg), a tetrapeptide that preserves cardiolipin content in the mitochondrial inner membrane.
  9. 09LabIn vitro (cells)Efficacy outcome

    In swine renal artery endothelial cells stressed with tert-butyl hydroperoxide, Bendavia normalized endothelial function.

    In plain wordsIn lab-grown pig kidney artery cells under oxidative stress, Bendavia returned the cells' function to normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseEndothelial function in vitro
    Study

    pign: not reported in source

    Swine renal artery endothelial cells with tert-butyl hydroperoxide
    Outcome group
    Kidney function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    renovascular endothelial function normalized both in vivo and in vitro.
    1 context sentence
    Summary · context
    In addition, swine renal artery endothelial cells incubated with tert-butyl hydroperoxide were also treated with Bendavia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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