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Study · Animal study (in vivo) · rat · 2015

8 results

Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart.

Shi J, Dai W, Hale SL, Brown DA, Wang M, Han X, Kloner RA

Life sciences6 Oct 2015Cited by 52 (Europe PMC)

PMID26431885 (opens in a new tab)PMCIDPMC4973309 (opens in a new tab)DOI10.1016/j.lfs.2015.09.022 (opens in a new tab)PepBankPUB-26431885
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Bendavia largely reversed the down-regulation of mitochondrial energy metabolism genes in the border zone.

    In plain wordsIn rats with a heart attack, Bendavia largely restored the activity of energy-related mitochondrial genes near the damaged area, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial energy metabolism gene expression in border zone
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    This down-regulation was largely reversed by Bendavia treatment.
    2 context sentences
    Summary · context
    There was decreased expression of 70 out of 84 genes related to mitochondrial energy metabolism in the border zone of untreated hearts.
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Bendavia restored the down-regulated mitochondrial biogenesis genes.

    In plain wordsIn rats with a heart attack, Bendavia restored genes for building mitochondria, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial biogenesis gene expression
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Downregulated mitochondrial biogenesis and glucose & fatty acid (FA) oxidation related genes were restored by administration of Bendavia.
    1 context sentence
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Bendavia restored the down-regulated glucose oxidation genes.

    In plain wordsIn rats with a heart attack, Bendavia restored genes for using glucose for energy, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGlucose oxidation gene expression
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Downregulated mitochondrial biogenesis and glucose & fatty acid (FA) oxidation related genes were restored by administration of Bendavia.
    1 context sentence
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Bendavia restored the down-regulated fatty acid oxidation genes.

    In plain wordsIn rats with a heart attack, Bendavia restored genes for using fat for energy, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseFatty acid oxidation gene expression
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Downregulated mitochondrial biogenesis and glucose & fatty acid (FA) oxidation related genes were restored by administration of Bendavia.
    1 context sentence
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Bendavia completely prevented the up-regulation of MMP9 in the border zone.

    In plain wordsIn rats with a heart attack, Bendavia prevented a rise in MMP9, a tissue-remodeling gene, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMMP9 gene expression
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Lung injury and fibrosis · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Bendavia completely prevented up-regulation of MMP9, but maintained TIMP1 gene expression.
    2 context sentences
    Summary · context
    Matrix metalloproteinase (MMP9) and tissue inhibitor of metalloproteinase (TIMP1) gene expression were significantly increased in the border zone of untreated hearts.
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Bendavia maintained TIMP1 gene expression in the border zone.

    In plain wordsIn rats with a heart attack, Bendavia maintained the activity of the TIMP1 gene, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeTIMP1 gene expression
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Lung injury and fibrosis · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Bendavia completely prevented up-regulation of MMP9, but maintained TIMP1 gene expression.
    2 context sentences
    Summary · context
    Matrix metalloproteinase (MMP9) and tissue inhibitor of metalloproteinase (TIMP1) gene expression were significantly increased in the border zone of untreated hearts.
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial infarction, Bendavia suppressed collagen deposition within the border zone.

    In plain wordsIn rats with a heart attack, Bendavia reduced scar-like collagen build-up near the damaged heart area, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCollagen deposition in border zone
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Lung injury and fibrosis · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Picrosirius red staining demonstrated that Bendavia suppressed collagen deposition within border zone.
    1 context sentence
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial infarction, Bendavia showed only a trend toward restoring SERCA2a expression.

    In plain wordsIn rats with a heart attack, Bendavia showed only a trend toward restoring SERCA2a, a heart calcium pump, compared with water.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeSERCA2a expression
    Study

    ratn: not reported in source

    Myocardial infarction by left coronary artery ligation
    Comparator
    Water
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    3 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    In addition, Bendavia showed a trend toward restoring SERCA2a expression.
    1 context sentence
    Summary · context
    Starting 2h after left coronary artery ligation, rats were randomized to receive Bendavia (3mg/kg/day), water or sham operation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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