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Study · Animal study (in vivo) · pig · 2014

6 results

Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension.

Eirin A, Williams BJ, Ebrahimi B, Zhang X, Crane JA, Lerman A, Textor SC, Lerman LO

Journal of hypertension1 Jan 2014Cited by 44 (Europe PMC)

PMID24048008 (opens in a new tab)PMCIDPMC3976567 (opens in a new tab)DOI10.1097/hjh.0b013e3283658a53 (opens in a new tab)PepBankPUB-24048008
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In swine with reversed renovascular hypertension, adjunct Bendavia was associated with improved diastolic function versus vehicle.

    In plain wordsIn pigs with reversed kidney-artery high blood pressure, Bendavia was linked to better heart relaxation than vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiastolic function after PTRS
    Study

    pign: not reported in source

    Swine renovascular hypertension with PTRS
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.05 mg/kg · intravenous · 30 min before to 3.5 h after PTRSAs given in this study (pig).

    Source sentences

    Summary
    in association with improvement in diastolic function in RVHT + PTRS + Bendavia animals.
    2 context sentences
    Summary · context
    After 6 weeks of RVHT (unilateral renal artery stenosis) or control, pigs underwent PTRS (or sham), with adjunct continuous infusion of Bendavia (0.05  mg/kg intravenously, 30  min before to 3.5  h after PTRS) or vehicle (n = 7 each).
    Summary · context
    Four weeks later, systolic and diastolic function were assessed by multidetector computed tomography, myocardial oxygenation by blood oxygen level-dependent MRI, and myocardial morphology, apoptosis, mitochondrial biogenesis, and fibrosis evaluated ex vivo.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In swine with reversed renovascular hypertension, adjunct Bendavia improved myocardial oxygenation versus vehicle.

    In plain wordsIn pigs with reversed kidney-artery high blood pressure, Bendavia improved heart muscle oxygen levels compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMyocardial oxygenation
    Study

    pign: not reported in source

    Swine renovascular hypertension with PTRS
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.05 mg/kg · intravenous · 30 min before to 3.5 h after PTRSAs given in this study (pig).

    Source sentences

    Summary
    Myocardial oxygenation and mitochondrial biogenesis improved, and myocardial inflammation, oxidative stress, and fibrosis normalized in association with improvement in diastolic function in RVHT + PTRS + Bendavia animals.
    2 context sentences
    Summary · context
    After 6 weeks of RVHT (unilateral renal artery stenosis) or control, pigs underwent PTRS (or sham), with adjunct continuous infusion of Bendavia (0.05  mg/kg intravenously, 30  min before to 3.5  h after PTRS) or vehicle (n = 7 each).
    Summary · context
    Four weeks later, systolic and diastolic function were assessed by multidetector computed tomography, myocardial oxygenation by blood oxygen level-dependent MRI, and myocardial morphology, apoptosis, mitochondrial biogenesis, and fibrosis evaluated ex vivo.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In swine with reversed renovascular hypertension, adjunct Bendavia improved myocardial mitochondrial biogenesis versus vehicle.

    In plain wordsIn pigs with reversed kidney-artery high blood pressure, Bendavia improved the making of new mitochondria in heart muscle compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMyocardial mitochondrial biogenesis
    Study

    pign: not reported in source

    Swine renovascular hypertension with PTRS
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.05 mg/kg · intravenous · 30 min before to 3.5 h after PTRSAs given in this study (pig).

    Source sentences

    Summary
    Myocardial oxygenation and mitochondrial biogenesis improved, and myocardial inflammation, oxidative stress, and fibrosis normalized in association with improvement in diastolic function in RVHT + PTRS + Bendavia animals.
    2 context sentences
    Summary · context
    After 6 weeks of RVHT (unilateral renal artery stenosis) or control, pigs underwent PTRS (or sham), with adjunct continuous infusion of Bendavia (0.05  mg/kg intravenously, 30  min before to 3.5  h after PTRS) or vehicle (n = 7 each).
    Summary · context
    Four weeks later, systolic and diastolic function were assessed by multidetector computed tomography, myocardial oxygenation by blood oxygen level-dependent MRI, and myocardial morphology, apoptosis, mitochondrial biogenesis, and fibrosis evaluated ex vivo.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In swine with reversed renovascular hypertension, adjunct Bendavia normalized myocardial inflammation versus vehicle.

    In plain wordsIn pigs with reversed kidney-artery high blood pressure, Bendavia brought heart muscle inflammation back to normal compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial inflammation
    Study

    pign: not reported in source

    Swine renovascular hypertension with PTRS
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    0.05 mg/kg · intravenous · 30 min before to 3.5 h after PTRSAs given in this study (pig).

    Source sentences

    Summary
    myocardial inflammation, oxidative stress, and fibrosis normalized in association with improvement in diastolic function in RVHT + PTRS + Bendavia animals.
    2 context sentences
    Summary · context
    After 6 weeks of RVHT (unilateral renal artery stenosis) or control, pigs underwent PTRS (or sham), with adjunct continuous infusion of Bendavia (0.05  mg/kg intravenously, 30  min before to 3.5  h after PTRS) or vehicle (n = 7 each).
    Summary · context
    Four weeks later, systolic and diastolic function were assessed by multidetector computed tomography, myocardial oxygenation by blood oxygen level-dependent MRI, and myocardial morphology, apoptosis, mitochondrial biogenesis, and fibrosis evaluated ex vivo.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In swine with reversed renovascular hypertension, adjunct Bendavia normalized myocardial oxidative stress versus vehicle.

    In plain wordsIn pigs with reversed kidney-artery high blood pressure, Bendavia brought heart muscle oxidative stress back to normal compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial oxidative stress
    Study

    pign: not reported in source

    Swine renovascular hypertension with PTRS
    Comparator
    Vehicle
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    0.05 mg/kg · intravenous · 30 min before to 3.5 h after PTRSAs given in this study (pig).

    Source sentences

    Summary
    myocardial inflammation, oxidative stress, and fibrosis normalized in association with improvement in diastolic function in RVHT + PTRS + Bendavia animals.
    2 context sentences
    Summary · context
    After 6 weeks of RVHT (unilateral renal artery stenosis) or control, pigs underwent PTRS (or sham), with adjunct continuous infusion of Bendavia (0.05  mg/kg intravenously, 30  min before to 3.5  h after PTRS) or vehicle (n = 7 each).
    Summary · context
    Four weeks later, systolic and diastolic function were assessed by multidetector computed tomography, myocardial oxygenation by blood oxygen level-dependent MRI, and myocardial morphology, apoptosis, mitochondrial biogenesis, and fibrosis evaluated ex vivo.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In swine with reversed renovascular hypertension, adjunct Bendavia normalized myocardial fibrosis versus vehicle.

    In plain wordsIn pigs with reversed kidney-artery high blood pressure, Bendavia brought heart muscle scarring back to normal compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial fibrosis
    Study

    pign: not reported in source

    Swine renovascular hypertension with PTRS
    Comparator
    Vehicle
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    0.05 mg/kg · intravenous · 30 min before to 3.5 h after PTRSAs given in this study (pig).

    Source sentences

    Summary
    myocardial inflammation, oxidative stress, and fibrosis normalized in association with improvement in diastolic function in RVHT + PTRS + Bendavia animals.
    2 context sentences
    Summary · context
    After 6 weeks of RVHT (unilateral renal artery stenosis) or control, pigs underwent PTRS (or sham), with adjunct continuous infusion of Bendavia (0.05  mg/kg intravenously, 30  min before to 3.5  h after PTRS) or vehicle (n = 7 each).
    Summary · context
    Four weeks later, systolic and diastolic function were assessed by multidetector computed tomography, myocardial oxygenation by blood oxygen level-dependent MRI, and myocardial morphology, apoptosis, mitochondrial biogenesis, and fibrosis evaluated ex vivo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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