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Study · Animal study (in vivo) · mouse · 2019

16 results

SS31 Ameliorates Sepsis-Induced Heart Injury by Inhibiting Oxidative Stress and Inflammation.

Liu Y, Yang W, Sun X, Xie L, Yang Y, Sang M, Jiao R

Inflammation1 Dec 2019Cited by 49 (Europe PMC)

PMID31494795 (opens in a new tab)DOI10.1007/s10753-019-01081-3 (opens in a new tab)PepBankPUB-31494795
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS31 restored myocardial morphological damage.

    In plain wordsIn mice with sepsis, SS31 restored damage to the heart tissue structure.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial morphological damage
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    SS31 restored myocardial morphological damage
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS31 significantly decreased IL-6 mRNA levels.

    In plain wordsIn mice with sepsis, SS31 lowered heart levels of the inflammation signal IL-6.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIL-6 mRNA level in heart
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    SS31 restored myocardial morphological damage and suppressed inflammatory response as evidenced by significantly decreasing the mRNA levels of IL-6, IL-1β, and TNF-α in vitro and in vivo.
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS31 significantly decreased IL-1β mRNA levels.

    In plain wordsIn mice with sepsis, SS31 lowered heart levels of the inflammation signal IL-1β.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIL-1β mRNA level in heart
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    SS31 restored myocardial morphological damage and suppressed inflammatory response as evidenced by significantly decreasing the mRNA levels of IL-6, IL-1β, and TNF-α in vitro and in vivo.
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS31 significantly decreased TNF-α mRNA levels.

    In plain wordsIn mice with sepsis, SS31 lowered heart levels of the inflammation signal TNF-α.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTNF-α mRNA level in heart
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    SS31 restored myocardial morphological damage and suppressed inflammatory response as evidenced by significantly decreasing the mRNA levels of IL-6, IL-1β, and TNF-α in vitro and in vivo.
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS31 remarkably ameliorated myocardial energy deficiency secondary to sepsis.

    In plain wordsIn mice with sepsis, SS31 clearly improved the heart's energy shortage caused by sepsis.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial energy deficiency secondary to sepsis
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    In addition, myocardial energy deficiency secondary to sepsis was remarkedly ameliorated by SS31.
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS‑31 normalized malondialdehyde activity.

    In plain wordsIn mice with sepsis, SS‑31 brought a marker of oxidative damage back toward normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMalondialdehyde activity in vivo
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    we found that SS-31 normalized the activity of malondialdehyde, glutathione peroxidase, and superoxide dismutase in vitro and in vivo
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS‑31 normalized glutathione peroxidase activity.

    In plain wordsIn mice with sepsis, SS‑31 brought an antioxidant enzyme's activity back toward normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGlutathione peroxidase activity in vivo
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    we found that SS-31 normalized the activity of malondialdehyde, glutathione peroxidase, and superoxide dismutase in vitro and in vivo
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced sepsis, SS‑31 normalized superoxide dismutase activity.

    In plain wordsIn mice with sepsis, SS‑31 brought another antioxidant enzyme's activity back toward normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSuperoxide dismutase activity in vivo
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    we found that SS-31 normalized the activity of malondialdehyde, glutathione peroxidase, and superoxide dismutase in vitro and in vivo
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  9. 09AnimalAnimal study (in vivo)Mechanism

    Western blot results indicated that the cardioprotective effect of SS31 was partly linked to NF-κB.

    In plain wordsIn sepsis experiments, SS31's heart protection was partly linked to the NF-κB signaling pathway.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableNF-κB involvement in cardioprotection
    Study

    mousen: not reported in source

    LPS-induced sepsis heart injury
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    the cardioprotective effect of SS31 was partly linked to NF-κB.
    1 context sentence
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  10. 10LabIn vitro (cells)Efficacy outcome

    In H9C2 cells treated with LPS, SS31 significantly decreased IL-6 mRNA levels.

    In plain wordsIn heart cells exposed to LPS, SS31 lowered levels of the inflammation signal IL-6.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIL-6 mRNA level in H9C2 cells
    Study

    n: not reported in source

    H9C2 cells treated with LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    10 μMAs given in this study.

    Source sentences

    Summary
    SS31 restored myocardial morphological damage and suppressed inflammatory response as evidenced by significantly decreasing the mRNA levels of IL-6, IL-1β, and TNF-α in vitro and in vivo.
    2 context sentences
    Summary · context
    H9C2 cell were treated with LPS with or without the presence of SS31 (10 μM) at 37 °C to assess the effect on cardiomyocytes at the indicated time points.
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  11. 11LabIn vitro (cells)Efficacy outcome

    In H9C2 cells treated with LPS, SS31 significantly decreased IL-1β mRNA levels.

    In plain wordsIn heart cells exposed to LPS, SS31 lowered levels of the inflammation signal IL-1β.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIL-1β mRNA level in H9C2 cells
    Study

    n: not reported in source

    H9C2 cells treated with LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    10 μMAs given in this study.

    Source sentences

    Summary
    SS31 restored myocardial morphological damage and suppressed inflammatory response as evidenced by significantly decreasing the mRNA levels of IL-6, IL-1β, and TNF-α in vitro and in vivo.
    2 context sentences
    Summary · context
    H9C2 cell were treated with LPS with or without the presence of SS31 (10 μM) at 37 °C to assess the effect on cardiomyocytes at the indicated time points.
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  12. 12LabIn vitro (cells)Efficacy outcome

    In H9C2 cells treated with LPS, SS31 significantly decreased TNF-α mRNA levels.

    In plain wordsIn heart cells exposed to LPS, SS31 lowered levels of the inflammation signal TNF-α.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTNF-α mRNA level in H9C2 cells
    Study

    n: not reported in source

    H9C2 cells treated with LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    10 μMAs given in this study.

    Source sentences

    Summary
    SS31 restored myocardial morphological damage and suppressed inflammatory response as evidenced by significantly decreasing the mRNA levels of IL-6, IL-1β, and TNF-α in vitro and in vivo.
    2 context sentences
    Summary · context
    H9C2 cell were treated with LPS with or without the presence of SS31 (10 μM) at 37 °C to assess the effect on cardiomyocytes at the indicated time points.
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  13. 13LabIn vitro (cells)Efficacy outcome

    In H9C2 cells treated with LPS, SS‑31 normalized malondialdehyde activity.

    In plain wordsIn heart cells exposed to LPS, SS‑31 brought a marker of oxidative damage back toward normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMalondialdehyde activity in H9C2 cells
    Study

    n: not reported in source

    H9C2 cells treated with LPS
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    10 μMAs given in this study.

    Source sentences

    Summary
    we found that SS-31 normalized the activity of malondialdehyde, glutathione peroxidase, and superoxide dismutase in vitro and in vivo
    2 context sentences
    Summary · context
    H9C2 cell were treated with LPS with or without the presence of SS31 (10 μM) at 37 °C to assess the effect on cardiomyocytes at the indicated time points.
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  14. 14LabIn vitro (cells)Efficacy outcome

    In H9C2 cells treated with LPS, SS‑31 normalized glutathione peroxidase activity.

    In plain wordsIn heart cells exposed to LPS, SS‑31 brought an antioxidant enzyme's activity back toward normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGlutathione peroxidase activity in H9C2 cells
    Study

    n: not reported in source

    H9C2 cells treated with LPS
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    10 μMAs given in this study.

    Source sentences

    Summary
    we found that SS-31 normalized the activity of malondialdehyde, glutathione peroxidase, and superoxide dismutase in vitro and in vivo
    2 context sentences
    Summary · context
    H9C2 cell were treated with LPS with or without the presence of SS31 (10 μM) at 37 °C to assess the effect on cardiomyocytes at the indicated time points.
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  15. 15LabIn vitro (cells)Efficacy outcome

    In H9C2 cells treated with LPS, SS‑31 normalized superoxide dismutase activity.

    In plain wordsIn heart cells exposed to LPS, SS‑31 brought another antioxidant enzyme's activity back toward normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSuperoxide dismutase activity in H9C2 cells
    Study

    n: not reported in source

    H9C2 cells treated with LPS
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    10 μMAs given in this study.

    Source sentences

    Summary
    we found that SS-31 normalized the activity of malondialdehyde, glutathione peroxidase, and superoxide dismutase in vitro and in vivo
    2 context sentences
    Summary · context
    H9C2 cell were treated with LPS with or without the presence of SS31 (10 μM) at 37 °C to assess the effect on cardiomyocytes at the indicated time points.
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).
  16. 16LabIn vitro (cells)Mechanism

    In H9C2 cells treated with LPS, SS‑31 maintained mitochondrial membrane potential.

    In plain wordsIn heart cells exposed to LPS, SS‑31 kept the mitochondrial membrane potential from falling.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    n: not reported in source

    H9C2 cells treated with LPS
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    10 μMAs given in this study.

    Source sentences

    Summary
    maintained mitochondrial membrane potential (MMP) as well
    2 context sentences
    Summary · context
    H9C2 cell were treated with LPS with or without the presence of SS31 (10 μM) at 37 °C to assess the effect on cardiomyocytes at the indicated time points.
    Summary · context
    Thirty-five C57BL/6 mice were randomly divided into four groups: sham group, LPS group (5 mg/kg), SS31 group (5 mg/kg), and SS31 + LPS group (treatment group).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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