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Study · Animal study (in vivo) · mouse · 2016

3 results

BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice.

Wu J, Zhang M, Li H, Sun X, Hao S, Ji M, Yang J, Li K

Behavioural brain research2 Mar 2016Cited by 57 (Europe PMC)

PMID26944333 (opens in a new tab)DOI10.1016/j.bbr.2016.02.036 (opens in a new tab)PepBankPUB-26944333
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aging mice exposed to isoflurane, SS‑31 rescued the isoflurane-induced cognitive deficits.

    In plain wordsIn aging mice, SS‑31 reduced the memory and behavior problems caused by isoflurane anesthesia.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIsoflurane-induced cognitive deficits
    Study

    mousen: not reported in source

    Isoflurane-induced cognitive deficits in 15-month-old mice
    Comparator
    Vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Of note, the isoflurane-induced cognitive deficits were rescued by SS-31 through reversal of mitochondrial dysfunction, which facilitated the regulation of BDNF signaling including the expression reversal of aforementioned important synaptic-signaling proteins in aging mice.
    1 context sentence
    Summary · context
    Fifteen-month-old male C57BL/6 mice were exposed to isoflurane for two hours following intraperitoneal administration of mitochondrion-targeted peptide SS-31 or vehicle with 30min interval.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In aging mice exposed to isoflurane, SS‑31 reversed mitochondrial dysfunction in the hippocampus.

    In plain wordsIn aging mice, SS‑31 reversed mitochondrial problems in the brain caused by isoflurane.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHippocampal mitochondrial dysfunction
    Study

    mousen: not reported in source

    Isoflurane-induced cognitive deficits in 15-month-old mice
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Of note, the isoflurane-induced cognitive deficits were rescued by SS-31 through reversal of mitochondrial dysfunction, which facilitated the regulation of BDNF signaling including the expression reversal of aforementioned important synaptic-signaling proteins in aging mice.
    2 context sentences
    Summary · context
    We showed that cognitive deficits induced by exposure of the aging mice to isoflurane were accompanied by mitochondrial dysfunction in hippocampus due to loss of the enzymatic activity of complex I.
    Summary · context
    Fifteen-month-old male C57BL/6 mice were exposed to isoflurane for two hours following intraperitoneal administration of mitochondrion-targeted peptide SS-31 or vehicle with 30min interval.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aging mice exposed to isoflurane, SS‑31 reversed the changes in BDNF signaling and synaptic-signaling protein expression.

    In plain wordsIn aging mice, SS‑31 reversed isoflurane-induced changes in BDNF signaling and in proteins that support nerve connections.

    Peptide
    Elamipretide (SS-31)
    Outcome
    MixedBDNF signaling and synaptic proteins
    Study

    mousen: not reported in source

    Isoflurane-induced cognitive deficits in 15-month-old mice
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Of note, the isoflurane-induced cognitive deficits were rescued by SS-31 through reversal of mitochondrial dysfunction, which facilitated the regulation of BDNF signaling including the expression reversal of aforementioned important synaptic-signaling proteins in aging mice.
    2 context sentences
    Summary · context
    Further, we provided evidence that the BDNF signaling pathway was involved in this process to regulate synaptic plasticity-related proteins, for instance, downregulation of synapsin 1, PSD-95 and p-CREB, and upregulation of NR2A, NR2B, CaMKIIα and CaMKIIβ.
    Summary · context
    Fifteen-month-old male C57BL/6 mice were exposed to isoflurane for two hours following intraperitoneal administration of mitochondrion-targeted peptide SS-31 or vehicle with 30min interval.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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