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Study · Animal study (in vivo) · mouse · 2019

6 results

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Zhao W, Xu Z, Cao J, Fu Q, Wu Y, Zhang X, Long Y, Zhang X, Yang Y, Li Y, Mi W

Journal of neuroinflammation20 Nov 2019Cited by 176 (Europe PMC)

PMID31747905 (opens in a new tab)PMCIDPMC6865061 (opens in a new tab)DOI10.1186/s12974-019-1627-9 (opens in a new tab)PepBankPUB-31747905
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Summary

BackgroundIt is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced memory impairment. Elamipretide (SS-31) is a novel mitochondrion-targeted antioxidant. However, the impact of elamipretide on the cognitive sequelae of inflammatory and oxidative stress is unknown.MethodsWe utilized MWM and contextual fear conditioning test to assess hippocampus-related learning and memory performance. Molecular biology techniques and ELISA were used to examine mitochondrial function, oxidative stress, and the inflammatory response. TUNEL and Golgi-staining was used to detect neural cell apoptosis and the density of dendritic spines in the mouse hippocampus.ResultsMice treated with LPS exhibited mitochondrial dysfunction, oxidative stress, an inflammatory response, neural cell apoptosis, and loss of dendritic spines in the hippocampus, leading to impaired hippocampus-related learning and memory performance in the MWM and contextual fear conditioning test. Treatment with elamipretide significantly ameliorated LPS-induced learning and memory impairment during behavioral tests. Notably, elamipretide not only provided protective effects against mitochondrial dysfunction and oxidative stress but also facilitated the regulation of brain-derived neurotrophic factor (BDNF) signaling, including the reversal of important synaptic-signaling proteins and increased synaptic structural complexity.ConclusionThese findings indicate that LPS-induced memory impairment can be attenuated by the mitochondrion-targeted antioxidant elamipretide. Consequently, elamipretide may have a therapeutic potential in preventing damage from the oxidative stress and neuroinflammation that contribute to perioperative neurocognitive disorders (PND), which makes mitochondria a potential target for treatment strategies for PND.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced memory impairment, elamipretide significantly ameliorated learning and memory impairment in behavioral tests.

    In plain wordsIn mice given LPS, elamipretide improved the learning and memory problems seen in behavioral tests.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLPS-induced learning and memory impairment
    Study

    mousen: not reported in source

    LPS-induced memory impairment
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with elamipretide significantly ameliorated LPS-induced learning and memory impairment during behavioral tests.
    1 context sentence
    Summary · context
    We utilized MWM and contextual fear conditioning test to assess hippocampus-related learning and memory performance.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced memory impairment, elamipretide provided protective effects against mitochondrial dysfunction.

    In plain wordsIn mice given LPS, elamipretide protected against mitochondrial dysfunction in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial dysfunction
    Study

    mousen: not reported in source

    LPS-induced memory impairment
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    elamipretide not only provided protective effects against mitochondrial dysfunction and oxidative stress
    1 context sentence
    Summary · context
    We utilized MWM and contextual fear conditioning test to assess hippocampus-related learning and memory performance.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced memory impairment, elamipretide provided protective effects against oxidative stress.

    In plain wordsIn mice given LPS, elamipretide protected against oxidative stress in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress
    Study

    mousen: not reported in source

    LPS-induced memory impairment
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    elamipretide not only provided protective effects against mitochondrial dysfunction and oxidative stress
    1 context sentence
    Summary · context
    We utilized MWM and contextual fear conditioning test to assess hippocampus-related learning and memory performance.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced memory impairment, elamipretide facilitated the regulation of brain-derived neurotrophic factor (BDNF) signaling.

    In plain wordsIn mice given LPS, elamipretide helped regulate BDNF signaling, a pathway that supports nerve cell function.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableBDNF signaling
    Study

    mousen: not reported in source

    LPS-induced memory impairment
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    facilitated the regulation of brain-derived neurotrophic factor (BDNF) signaling
    1 context sentence
    Summary · context
    We utilized MWM and contextual fear conditioning test to assess hippocampus-related learning and memory performance.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced memory impairment, elamipretide reversed changes in important synaptic-signaling proteins.

    In plain wordsIn mice given LPS, elamipretide reversed changes in proteins that carry signals between nerve cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableSynaptic-signaling proteins
    Study

    mousen: not reported in source

    LPS-induced memory impairment
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the reversal of important synaptic-signaling proteins
    1 context sentence
    Summary · context
    We utilized MWM and contextual fear conditioning test to assess hippocampus-related learning and memory performance.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced memory impairment, elamipretide increased synaptic structural complexity.

    In plain wordsIn mice given LPS, elamipretide increased the structural complexity of nerve cell connections.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSynaptic structural complexity
    Study

    mousen: not reported in source

    LPS-induced memory impairment
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased synaptic structural complexity.
    1 context sentence
    Summary · context
    We utilized MWM and contextual fear conditioning test to assess hippocampus-related learning and memory performance.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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