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Study · Animal study (in vivo) · rat · 2017

7 results

Role of mitochondrial dysfunction in renal fibrosis promoted by hypochlorite-modified albumin in a remnant kidney model and protective effects of antioxidant peptide SS-31.

Zhao H, Liu YJ, Liu ZR, Tang DD, Chen XW, Chen YH, Zhou RN, Chen SQ, Niu HX

European journal of pharmacology18 Mar 2017Cited by 43 (Europe PMC)

PMID28322835 (opens in a new tab)DOI10.1016/j.ejphar.2017.03.037 (opens in a new tab)PepBankPUB-28322835
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In remnant-kidney rats challenged with HOCl-modified albumin, SS‑31 prevented the exacerbated mitochondrial dysfunction.

    In plain wordsIn rats with reduced kidney tissue, SS‑31 prevented the added mitochondrial damage caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial dysfunction in renal tissue
    Study

    ratn: not reported in source

    5/6 nephrectomy remnant-kidney model with HOCl-modified albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    HOCl-alb challenge further exacerbated the above biological effects in 5/6 NX animals, but these adverse effects were prevented by administration of SS-31, a mitochondrial targeted antioxidant peptide.
    2 context sentences
    Summary · context
    5/6 NX animals displayed marked mitochondrial (mt) dysfunction, as evidenced by decrease of mitochondrial membrane potential (MMP)
    Summary · context
    Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In remnant-kidney rats challenged with HOCl-modified albumin, SS‑31 prevented the exacerbated accumulation of extracellular matrix.

    In plain wordsIn rats with reduced kidney tissue, SS‑31 prevented the added build-up of scar-like material caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseExtracellular matrix accumulation
    Study

    ratn: not reported in source

    5/6 nephrectomy remnant-kidney model with HOCl-modified albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    HOCl-alb challenge further exacerbated the above biological effects in 5/6 NX animals, but these adverse effects were prevented by administration of SS-31, a mitochondrial targeted antioxidant peptide.
    2 context sentences
    Summary · context
    These changes were accompanied by accumulation of extracellular matrix, worsened proteinuria, deteriorated renal function, and a marked increase of macrophage infiltration along with up-regulation of monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β1 expression.
    Summary · context
    Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In remnant-kidney rats challenged with HOCl-modified albumin, SS‑31 prevented the exacerbated proteinuria.

    In plain wordsIn rats with reduced kidney tissue, SS‑31 prevented the added protein loss in urine caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseProteinuria
    Study

    ratn: not reported in source

    5/6 nephrectomy remnant-kidney model with HOCl-modified albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    HOCl-alb challenge further exacerbated the above biological effects in 5/6 NX animals, but these adverse effects were prevented by administration of SS-31, a mitochondrial targeted antioxidant peptide.
    2 context sentences
    Summary · context
    These changes were accompanied by accumulation of extracellular matrix, worsened proteinuria, deteriorated renal function, and a marked increase of macrophage infiltration along with up-regulation of monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β1 expression.
    Summary · context
    Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In remnant-kidney rats challenged with HOCl-modified albumin, SS‑31 prevented the exacerbated deterioration of renal function.

    In plain wordsIn rats with reduced kidney tissue, SS‑31 prevented the added loss of kidney function caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal function deterioration
    Study

    ratn: not reported in source

    5/6 nephrectomy remnant-kidney model with HOCl-modified albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    HOCl-alb challenge further exacerbated the above biological effects in 5/6 NX animals, but these adverse effects were prevented by administration of SS-31, a mitochondrial targeted antioxidant peptide.
    2 context sentences
    Summary · context
    These changes were accompanied by accumulation of extracellular matrix, worsened proteinuria, deteriorated renal function, and a marked increase of macrophage infiltration along with up-regulation of monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β1 expression.
    Summary · context
    Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In remnant-kidney rats challenged with HOCl-modified albumin, SS‑31 prevented the exacerbated macrophage infiltration.

    In plain wordsIn rats with reduced kidney tissue, SS‑31 prevented the added immune-cell build-up in the kidney caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMacrophage infiltration
    Study

    ratn: not reported in source

    5/6 nephrectomy remnant-kidney model with HOCl-modified albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    HOCl-alb challenge further exacerbated the above biological effects in 5/6 NX animals, but these adverse effects were prevented by administration of SS-31, a mitochondrial targeted antioxidant peptide.
    2 context sentences
    Summary · context
    These changes were accompanied by accumulation of extracellular matrix, worsened proteinuria, deteriorated renal function, and a marked increase of macrophage infiltration along with up-regulation of monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β1 expression.
    Summary · context
    Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In remnant-kidney rats challenged with HOCl-modified albumin, SS‑31 prevented the exacerbated up-regulation of MCP-1.

    In plain wordsIn rats with reduced kidney tissue, SS‑31 prevented the added rise in the inflammation signal MCP-1 caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMCP-1 expression
    Study

    ratn: not reported in source

    5/6 nephrectomy remnant-kidney model with HOCl-modified albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    HOCl-alb challenge further exacerbated the above biological effects in 5/6 NX animals, but these adverse effects were prevented by administration of SS-31, a mitochondrial targeted antioxidant peptide.
    2 context sentences
    Summary · context
    These changes were accompanied by accumulation of extracellular matrix, worsened proteinuria, deteriorated renal function, and a marked increase of macrophage infiltration along with up-regulation of monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β1 expression.
    Summary · context
    Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In remnant-kidney rats challenged with HOCl-modified albumin, SS‑31 prevented the exacerbated up-regulation of TGF-β1.

    In plain wordsIn rats with reduced kidney tissue, SS‑31 prevented the added rise in the scarring signal TGF-β1 caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTGF-β1 expression
    Study

    ratn: not reported in source

    5/6 nephrectomy remnant-kidney model with HOCl-modified albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    HOCl-alb challenge further exacerbated the above biological effects in 5/6 NX animals, but these adverse effects were prevented by administration of SS-31, a mitochondrial targeted antioxidant peptide.
    2 context sentences
    Summary · context
    These changes were accompanied by accumulation of extracellular matrix, worsened proteinuria, deteriorated renal function, and a marked increase of macrophage infiltration along with up-regulation of monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β1 expression.
    Summary · context
    Five-sixths nephrectomy (5/6 NX) was performed on the rats and then the animals were randomly assigned to intravenous treatment with either vehicle alone, or HOCl-rat serum albumin (RSA) in the presence or absence of SS-31 (administered intraperitoneally).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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