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Study · Animal study (in vivo) · mouse · 2019

7 results

Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes.

Liu D, Jin F, Shu G, Xu X, Qi J, Kang X, Yu H, Lu K, Jiang S, Han F, You J, Du Y, Ji J

Biomaterials6 May 2019Cited by 128 (Europe PMC)

PMID31085359 (opens in a new tab)DOI10.1016/j.biomaterials.2019.04.034 (opens in a new tab)PepBankPUB-31085359
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse model of acute kidney injury, SS‑31 in nanopolyplexes had significantly higher therapeutic efficiency than bare SS‑31.

    In plain wordsIn mice with acute kidney injury, SS‑31 in nanoparticles worked better than SS‑31 alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseTherapeutic efficiency in AKI
    Study

    mousen: not reported in source

    Acute kidney injury (AKI) mouse model
    Comparator
    Bare SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AKI mouse model suggests that NPs have significantly higher therapeutic efficiency than bare SS-31.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute kidney injury, intravenous SS‑31 nanopolyplexes decreased oxidative stress.

    In plain wordsIn mice with acute kidney injury, SS‑31 in nanoparticles reduced oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress in AKI
    Study

    mousen: not reported in source

    Acute kidney injury (AKI) mouse model
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    It was found that NPs had excellent ability to decrease oxidative stress, protect mitochondrial structure, reduce inflammatory response, reduce apoptosis and necrosis of tubular cells after intravenious administration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute kidney injury, intravenous SS‑31 nanopolyplexes protected mitochondrial structure.

    In plain wordsIn mice with acute kidney injury, SS‑31 in nanoparticles protected mitochondrial structure.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial structure in AKI
    Study

    mousen: not reported in source

    Acute kidney injury (AKI) mouse model
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    It was found that NPs had excellent ability to decrease oxidative stress, protect mitochondrial structure, reduce inflammatory response, reduce apoptosis and necrosis of tubular cells after intravenious administration.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute kidney injury, intravenous SS‑31 nanopolyplexes reduced the inflammatory response.

    In plain wordsIn mice with acute kidney injury, SS‑31 in nanoparticles reduced inflammation.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInflammatory response in AKI
    Study

    mousen: not reported in source

    Acute kidney injury (AKI) mouse model
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    It was found that NPs had excellent ability to decrease oxidative stress, protect mitochondrial structure, reduce inflammatory response, reduce apoptosis and necrosis of tubular cells after intravenious administration.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute kidney injury, intravenous SS‑31 nanopolyplexes reduced apoptosis and necrosis of tubular cells.

    In plain wordsIn mice with acute kidney injury, SS‑31 in nanoparticles reduced death of kidney tube cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTubular cell apoptosis and necrosis in AKI
    Study

    mousen: not reported in source

    Acute kidney injury (AKI) mouse model
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (mouse).

    Source sentences

    Summary
    It was found that NPs had excellent ability to decrease oxidative stress, protect mitochondrial structure, reduce inflammatory response, reduce apoptosis and necrosis of tubular cells after intravenious administration.
  6. 06LabIn vitro (cells)Efficacy outcome

    In cells, SS‑31 delivered in pH-responsive nanopolyplexes had a higher antioxidative effect than free SS‑31.

    In plain wordsIn lab cells, SS‑31 in nanoparticles had a stronger antioxidant effect than SS‑31 alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseAntioxidative effect in vitro
    Study

    n: not reported in source

    Comparator
    Free SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro studies indicate that NPs exhibited higher antioxidative and antiapoptotic effects as compared with free SS-31.
  7. 07LabIn vitro (cells)Efficacy outcome

    In cells, SS‑31 delivered in pH-responsive nanopolyplexes had a higher antiapoptotic effect than free SS‑31.

    In plain wordsIn lab cells, SS‑31 in nanoparticles protected against cell death more than SS‑31 alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseAntiapoptotic effect in vitro
    Study

    n: not reported in source

    Comparator
    Free SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro studies indicate that NPs exhibited higher antioxidative and antiapoptotic effects as compared with free SS-31.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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