Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.

Thomas DA, Stauffer C, Zhao K, Yang H, Sharma VK, Szeto HH, Suthanthiran M

Journal of the American Society of Nephrology : JASN6 Dec 2006Cited by 70 (Europe PMC)

PMID17151329DOI10.1681/asn.2006080825PepBankPUB-17151329

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic mice given 200 islets from old donors, SS‑31 treatment was associated with prompt and sustained normoglycemia, whereas recipients of untreated islets remained diabetic.
In plain wordsIn diabetic mice given a small number of islets, SS‑31 treatment was linked to lasting normal blood sugar, while untreated recipients stayed diabetic.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseNormoglycemia after marginal islet mass transplantation
Study
mousen: not reported in source
Marginal islet mass transplantation (200 islets from old donor mice) in syngeneic diabetic mice
Comparator
Untreated islet graft recipients
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
In a stringent marginal islet cell mass transplantation model (200 mouse islets transplanted under the renal capsule of syngeneic diabetic mice) and using islets that were derived from old mice (>24 wk), SS-31 treatment was associated with prompt and sustained normoglycemia, whereas the untreated is…
Report a problemFND-1715132907
02LabEx vivo tissuePharmacokinetics
SS‑31 readily penetrated intact mouse islets.
In plain wordsIn lab tests, SS‑31 easily entered intact mouse pancreatic islets.
Peptide
Elamipretide (SS-31)
Outcome
Not applicableSS-31 penetration into intact islets
Study
mousen: not reported in source
Isolated mouse islets
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
SS-31 readily penetrates intact mouse islets, preserves mitochondrial polarization, reduces islet cell apoptosis, and increases islet cell yield.
Report a problemFND-1715132901
03LabEx vivo tissueMechanism
In isolated mouse islets, SS‑31 preserved mitochondrial polarization.
In plain wordsIn lab tests on mouse islets, SS‑31 kept the electrical balance of mitochondria intact.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseIslet mitochondrial polarization
Study
mousen: not reported in source
Isolated mouse islets
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
preserves mitochondrial polarization, reduces islet cell apoptosis, and increases islet cell yield.
Report a problemFND-1715132902
04LabEx vivo tissueEfficacy outcome
In isolated mouse islets, SS‑31 reduced islet cell apoptosis.
In plain wordsIn lab tests on mouse islets, SS‑31 reduced programmed cell death.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMouse islet cell apoptosis
Study
mousen: not reported in source
Isolated mouse islets
Outcome group
Cell viability and death · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
reduces islet cell apoptosis, and increases islet cell yield.
Report a problemFND-1715132903
05LabEx vivo tissueEfficacy outcome
In isolated mouse islets, SS‑31 increased islet cell yield.
In plain wordsIn lab tests on mouse islets, SS‑31 increased the number of islet cells recovered.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMouse islet cell yield
Study
mousen: not reported in source
Isolated mouse islets
Outcome group
Cell viability and death · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
increases islet cell yield.
Report a problemFND-1715132904
06LabEx vivo tissueEfficacy outcome
In cultured human islets, supplementing the culture medium with SS‑31 reduced islet cell apoptosis.
In plain wordsIn lab tests on human islets, adding SS‑31 to the culture medium reduced programmed cell death.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseHuman islet apoptosis
Study
humann: not reported in source
Cultured human islets
Outcome group
Cell viability and death · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
reduced islet cell apoptosis and increased the viability of human islets
Report a problemFND-1715132905
07LabEx vivo tissueEfficacy outcome
In cultured human islets, supplementing the culture medium with SS‑31 increased islet viability.
In plain wordsIn lab tests on human islets, adding SS‑31 to the culture medium increased the share of living cells.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseHuman islet viability
Study
humann: not reported in source
Cultured human islets
Outcome group
Cell viability and death · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
reduced islet cell apoptosis and increased the viability of human islets
Report a problemFND-1715132906

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

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