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Study · Animal study (in vivo) · rat · 2018

2 results

Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation.

Smuder AJ, Sollanek KJ, Nelson WB, Min K, Talbert EE, Kavazis AN, Hudson MB, Sandri M, Szeto HH, Powers SK

Free radical biology & medicine29 Nov 2017Cited by 88 (Europe PMC)

PMID29197632 (opens in a new tab)PMCIDPMC5767544 (opens in a new tab)DOI10.1016/j.freeradbiomed.2017.11.025 (opens in a new tab)PepBankPUB-29197632
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mechanically ventilated rats given SS‑31, mitochondrial ROS production was required for increased diaphragm expression of autophagy genes (LC3, Atg7, Atg12, Beclin1 and p62).

    In plain wordsIn ventilated rats, SS‑31 was used to show that mitochondrial ROS drive the rise of autophagy genes in the diaphragm.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAutophagy gene expression in the diaphragm
    Study

    ratn: not reported in source

    mechanically ventilated rats
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    To determine if increased ROS production is required for the upregulation of autophagy biomarkers in the diaphragm, rats that were administered the mitochondrial-targeted peptide SS-31 during MV.
    1 context sentence
    Summary · context
    Results from this study demonstrated that mitochondrial ROS production in the diaphragm during MV is required for the increased expression of key autophagy genes (i.e. LC3, Atg7, Atg12, Beclin1 and p62), as well as for increased activity of cathepsin L.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mechanically ventilated rats given SS‑31, mitochondrial ROS production was required for increased diaphragm cathepsin L activity.

    In plain wordsIn ventilated rats, SS‑31 was used to show that mitochondrial ROS drive the rise of cathepsin L activity in the diaphragm.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCathepsin L activity in the diaphragm
    Study

    ratn: not reported in source

    mechanically ventilated rats
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    To determine if increased ROS production is required for the upregulation of autophagy biomarkers in the diaphragm, rats that were administered the mitochondrial-targeted peptide SS-31 during MV.
    1 context sentence
    Summary · context
    Results from this study demonstrated that mitochondrial ROS production in the diaphragm during MV is required for the increased expression of key autophagy genes (i.e. LC3, Atg7, Atg12, Beclin1 and p62), as well as for increased activity of cathepsin L.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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