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Study · Animal study (in vivo) · mouse · 2016

3 results

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy.

Sakellariou GK, Pearson T, Lightfoot AP, Nye GA, Wells N, Giakoumaki II, Vasilaki A, Griffiths RD, Jackson MJ, McArdle A

Scientific reports29 Sept 2016Cited by 120 (Europe PMC)

PMID27681159 (opens in a new tab)PMCIDPMC5041117 (opens in a new tab)DOI10.1038/srep33944 (opens in a new tab)PepBankPUB-27681159
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Summary

Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The potential role of age-dependent mitochondrial dysfunction and cumulative oxidative stress as the underlying cause of muscle aging remains a controversial topic. Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice. However, this treatment failed to rescue the age-related muscle fiber atrophy associated with muscle atrophy and weakness. Collectively, these data imply that the muscle mitochondrial redox environment is not a key regulator of muscle fiber atrophy during sarcopenia but may play a key role in the decline of mitochondrial organelle integrity that occurs with muscle aging.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old mice, SS31 was associated with some improvement in oxidative damage in muscle.

    In plain wordsIn old mice, SS31 was linked to some less oxidative damage in muscle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMuscle oxidative damage
    Study

    mousen: not reported in source

    Aged mice (age-related muscle mitochondrial redox changes)
    Outcome group
    Aging markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old mice, SS31 was associated with some improvement in mitophagy in muscle.

    In plain wordsIn old mice, SS31 was linked to some improvement in how muscle cells clear damaged mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedMuscle mitophagy
    Study

    mousen: not reported in source

    Aged mice (age-related muscle mitochondrial redox changes)
    Outcome group
    Aging markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old mice, SS31 treatment failed to rescue age-related muscle fiber atrophy.

    In plain wordsIn old mice, SS31 did not reverse age-related shrinking of muscle fibers.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeAge-related muscle fiber atrophy
    Study

    mousen: not reported in source

    Aged mice (age-related muscle mitochondrial redox changes)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, this treatment failed to rescue the age-related muscle fiber atrophy associated with muscle atrophy and weakness.
    1 context sentence
    Summary · context
    Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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