Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.

Siegel MP, Kruse SE, Percival JM, Goh J, White CC, Hopkins HC, Kavanagh TJ, Szeto HH, Rabinovitch PS, Marcinek DJ

Aging cell11 Jun 2013Cited by 160 (Europe PMC)

PMID23692570PMCIDPMC3772966DOI10.1111/acel.12102PepBankPUB-23692570

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, a single SS‑31 injection reversed the age-related decline in resting mitochondrial ATP production in skeletal muscle.
In plain wordsIn old mice, one SS‑31 injection restored the lower resting energy production of muscle mitochondria compared with saline.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseResting mitochondrial ATP production in aged muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
Age-related declines in resting and maximal mitochondrial ATP production, coupling of oxidative phosphorylation (P/O), and cell energy state (PCr/ATP) were rapidly reversed after SS-31 treatment
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257001
02AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, a single SS‑31 injection reversed the age-related decline in maximal mitochondrial ATP production in skeletal muscle.
In plain wordsIn old mice, one SS‑31 injection restored the lower maximal energy production of muscle mitochondria compared with saline.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMaximal mitochondrial ATP production in aged muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
Age-related declines in resting and maximal mitochondrial ATP production, coupling of oxidative phosphorylation (P/O), and cell energy state (PCr/ATP) were rapidly reversed after SS-31 treatment
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257002
03AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, a single SS‑31 injection reversed the age-related decline in P/O, the coupling of oxidative phosphorylation, in skeletal muscle.
In plain wordsIn old mice, one SS‑31 injection restored the efficiency of muscle mitochondria compared with saline.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseCoupling of oxidative phosphorylation (P/O) in aged muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
Age-related declines in resting and maximal mitochondrial ATP production, coupling of oxidative phosphorylation (P/O), and cell energy state (PCr/ATP) were rapidly reversed after SS-31 treatment
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257003
04AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, a single SS‑31 injection reversed the age-related decline in cell energy state (PCr/ATP) in skeletal muscle.
In plain wordsIn old mice, one SS‑31 injection restored the lower energy state of muscle cells compared with saline.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseCell energy state (PCr/ATP) in aged muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
Age-related declines in resting and maximal mitochondrial ATP production, coupling of oxidative phosphorylation (P/O), and cell energy state (PCr/ATP) were rapidly reversed after SS-31 treatment
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257004
05AnimalAnimal study (in vivo)Efficacy outcome
In young mice, SS‑31 had no observable effect on skeletal muscle mitochondrial energetics.
In plain wordsIn young mice, SS‑31 had no observable effect on muscle energy production.
Peptide
Elamipretide (SS-31)
Outcome
No significant changeMitochondrial energetics in young muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
SS-31 had no observable effect on young muscle.
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257005
06AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, SS‑31 was associated with a more reduced glutathione redox status in skeletal muscle.
In plain wordsIn old mice, SS‑31 was linked to a less oxidized state of the muscle antioxidant glutathione.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseGlutathione redox status in aged muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
These effects of SS-31 on mitochondrial energetics in aged muscle were also associated with a more reduced glutathione redox status and lower mitochondrial H2 O2 emission.
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257006
07AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, SS‑31 was associated with lower mitochondrial H2O2 emission in skeletal muscle.
In plain wordsIn old mice, SS‑31 was linked to lower release of hydrogen peroxide from muscle mitochondria.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMitochondrial H2O2 emission in aged muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Mitochondrial function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
These effects of SS-31 on mitochondrial energetics in aged muscle were also associated with a more reduced glutathione redox status and lower mitochondrial H2 O2 emission.
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257007
08AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, skeletal muscle was more fatigue resistant in situ one hour after SS‑31 treatment.
In plain wordsIn old mice, muscle tired less easily one hour after SS‑31 treatment.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseIn situ fatigue resistance of aged muscle
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 1 hourAs given in this study (mouse).
Source sentences
Summary
Skeletal muscle of aged mice was more fatigue resistant in situ one hour after SS-31 treatment, and eight days of SS-31 treatment led to increased whole-animal endurance capacity.
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257008
09AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, eight days of SS‑31 treatment increased whole-animal endurance capacity.
In plain wordsIn old mice, eight days of SS‑31 treatment increased how long the animals could keep exercising.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseWhole-animal endurance capacity
Study
mousen: not reported in source
Aged mice (27 months) and young mice (5 months)
Comparator
Saline
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
3 mg/kg · intraperitoneal · 8 daysAs given in this study (mouse).
Source sentences
Summary
eight days of SS-31 treatment led to increased whole-animal endurance capacity.
2 context sentences(design, population, supporting numbers)
Summary · context
Young (5 month old) and old (27 month old) mice were injected intraperitoneally with either saline or 3 mg kg(-1) of SS-31.
Summary · context
Skeletal muscle mitochondrial energetics were measured in vivo one hour after injection using a unique combination of optical and (31) P magnetic resonance spectroscopy.
Report a problemFND-2369257009

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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