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Study · Animal study (in vivo) · mouse · 2009

6 results

Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.

Yang L, Zhao K, Calingasan NY, Luo G, Szeto HH, Beal MF

Antioxidants & redox signaling1 Sept 2009Cited by 138 (Europe PMC)

PMID19203217 (opens in a new tab)PMCIDPMC2819801 (opens in a new tab)DOI10.1089/ars.2009.2445 (opens in a new tab)PepBankPUB-19203217
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice given MPTP, SS‑31 produced dose-dependent complete protection against loss of dopamine and its metabolites in the striatum.

    In plain wordsIn mice given the toxin MPTP, SS‑31 fully protected against loss of dopamine in a dose-dependent way.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseStriatal dopamine and metabolite loss after MPTP
    Study

    mousen: not reported in source

    MPTP mouse model of Parkinson's disease
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 produced dose-dependent complete protection against loss of dopamine and its metabolites in striatum, as well as loss of tyrosine hydroxylase immunoreactive neurons in substantia nigra pars compacta.
    1 context sentence
    Summary · context
    In this study, we examined the ability of two peptides, SS-31 and SS-20, to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice given MPTP, SS‑31 produced dose-dependent complete protection against loss of tyrosine hydroxylase immunoreactive neurons in the substantia nigra pars compacta.

    In plain wordsIn mice given the toxin MPTP, SS‑31 fully protected dopamine-producing nerve cells in a dose-dependent way.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLoss of tyrosine hydroxylase neurons in substantia nigra after MPTP
    Study

    mousen: not reported in source

    MPTP mouse model of Parkinson's disease
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 produced dose-dependent complete protection against loss of dopamine and its metabolites in striatum, as well as loss of tyrosine hydroxylase immunoreactive neurons in substantia nigra pars compacta.
    1 context sentence
    Summary · context
    In this study, we examined the ability of two peptides, SS-31 and SS-20, to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice.
  3. 03LabEx vivo tissueMechanism

    In isolated mitochondria, SS‑31 prevented MPP+-induced inhibition of oxygen consumption.

    In plain wordsIn lab tests with isolated mitochondria, SS‑31 prevented the toxin MPP+ from blocking oxygen use.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMPP+-induced inhibition of oxygen consumption in isolated mitochondria
    Study

    n: not reported in source

    Isolated mitochondria
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Studies with isolated mitochondria showed that both SS-31 and SS-20 prevented MPP+-induced inhibition of oxygen consumption
  4. 04LabEx vivo tissueMechanism

    In isolated mitochondria, SS‑31 prevented MPP+-induced inhibition of ATP production.

    In plain wordsIn lab tests with isolated mitochondria, SS‑31 prevented the toxin MPP+ from blocking energy (ATP) production.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMPP+-induced inhibition of ATP production in isolated mitochondria
    Study

    n: not reported in source

    Isolated mitochondria
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Studies with isolated mitochondria showed that both SS-31 and SS-20 prevented MPP+-induced inhibition of oxygen consumption and ATP production
  5. 05LabEx vivo tissueMechanism

    In isolated mitochondria, SS‑31 prevented MPP+-induced mitochondrial swelling.

    In plain wordsIn lab tests with isolated mitochondria, SS‑31 prevented swelling of mitochondria caused by the toxin MPP+.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial swelling
    Study

    n: not reported in source

    Isolated mitochondria
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Studies with isolated mitochondria showed that both SS-31 and SS-20 prevented MPP+-induced inhibition of oxygen consumption and ATP production, and mitochondrial swelling
  6. 06LabIn vitro (cells)Efficacy outcome

    In cultured SN4741 dopamine cells, SS‑31 was very potent (nM) in preventing MPP+-induced cell death.

    In plain wordsIn cultured dopamine cells, SS‑31 prevented cell death caused by the toxin MPP+ at very low (nanomolar) concentrations.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMPP+-induced cell death in dopamine cells
    Study

    n: not reported in source

    Cultured dopamine cells (SN4741)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both SS-31 and SS-20 were very potent (nM) in preventing MPP+ (1-methyl-4-phenylpyridinium)-induced cell death in cultured dopamine cells (SN4741).
    1 context sentence
    Summary · context
    In this study, we examined the ability of two peptides, SS-31 and SS-20, to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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