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Study · Animal study (in vivo) · mouse · 2019

3 results

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes.

Ducasa GM, Mitrofanova A, Mallela SK, Liu X, Molina J, Sloan A, Pedigo CE, Ge M, Santos JV, Hernandez Y, Kim JJ, Maugeais C and 13 more

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Mendez AJ, Nair V, Kretzler M, Burke GW, Nelson RG, Ishimoto Y, Inagi R, Banerjee S, Liu S, Szeto HH, Merscher S, Fontanesi F, Fornoni A

The Journal of clinical investigation22 Jul 2019Cited by 166 (Europe PMC)

PMID31329164 (opens in a new tab)PMCIDPMC6668702 (opens in a new tab)DOI10.1172/jci125316 (opens in a new tab)PepBankPUB-31329164
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, inhibiting cardiolipin peroxidation with elamipretide improved diabetic kidney disease.

    In plain wordsIn mice, elamipretide improved diabetic kidney disease.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiabetic kidney disease severity in vivo
    Study

    mousen: not reported in source

    Diabetic kidney disease in mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibition of cardiolipin peroxidation with elamipretide improved DKD in vivo and prevented ABCA1-dependent podocyte injury in vitro and in vivo.
    1 context sentence
    Summary · context
    Podocyte-specific deletion of Abca1 (Abca1fl/fl) rendered mice susceptible to DKD, and pharmacological induction of ABCA1 improved established DKD
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, elamipretide prevented ABCA1-dependent podocyte injury.

    In plain wordsIn mice, elamipretide prevented podocyte injury caused by ABCA1 deficiency.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseABCA1-dependent podocyte injury in vivo
    Study

    mousen: not reported in source

    Abca1 podocyte-deficient mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    prevented ABCA1-dependent podocyte injury in vitro and in vivo.
    1 context sentence
    Summary · context
    Podocyte-specific deletion of Abca1 (Abca1fl/fl) rendered mice susceptible to DKD
  3. 03LabIn vitro (cells)Efficacy outcome

    In podocytes, elamipretide prevented ABCA1-dependent podocyte injury.

    In plain wordsIn podocyte cells, elamipretide prevented injury caused by ABCA1 deficiency.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseABCA1-dependent podocyte injury in vitro
    Study

    n: not reported in source

    Podocytes with ABCA1 knockdown
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    prevented ABCA1-dependent podocyte injury in vitro and in vivo.
    1 context sentence
    Summary · context
    siRNA ABCA1 knockdown in podocytes led to reduced oxygen consumption capabilities associated with alterations in the oxidative phosphorylation (OXPHOS) complexes and with cardiolipin accumulation

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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