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Study · Animal study (in vivo) · mouse · 2018

16 results

The antioxidant peptide SS31 prevents oxidative stress, downregulates CD36 and improves renal function in diabetic nephropathy.

Hou Y, Shi Y, Han B, Liu X, Qiao X, Qi Y, Wang L

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association1 Nov 2018Cited by 43 (Europe PMC)

PMID30388276 (opens in a new tab)DOI10.1093/ndt/gfy021 (opens in a new tab)PepBankPUB-30388276
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In db/db diabetic mice, SS31 alleviated proteinuria.

    In plain wordsIn diabetic mice, SS31 reduced protein loss in the urine.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseProteinuria
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that SS31 alleviated proteinuria, glomerular hypertrophy and tubular injury, and affected creatinine level in db/db mice.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In db/db diabetic mice, SS31 alleviated glomerular hypertrophy.

    In plain wordsIn diabetic mice, SS31 reduced enlargement of the kidney filter units.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGlomerular hypertrophy
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that SS31 alleviated proteinuria, glomerular hypertrophy and tubular injury, and affected creatinine level in db/db mice.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In db/db diabetic mice, SS31 alleviated tubular injury.

    In plain wordsIn diabetic mice, SS31 reduced injury to the kidney tubules.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTubular injury
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that SS31 alleviated proteinuria, glomerular hypertrophy and tubular injury, and affected creatinine level in db/db mice.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In db/db diabetic mice, SS31 affected the creatinine level; the abstract does not state the direction.

    In plain wordsIn diabetic mice, SS31 changed creatinine levels. The abstract does not say in which direction.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedCreatinine level
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that SS31 alleviated proteinuria, glomerular hypertrophy and tubular injury, and affected creatinine level in db/db mice.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In db/db diabetic mice, SS31 suppressed oxidative stress.

    In plain wordsIn diabetic mice, SS31 lowered signs of oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress level
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In db/db diabetic mice, SS31 suppressed the levels of NADPH oxidase subunits.

    In plain wordsIn diabetic mice, SS31 lowered levels of NADPH oxidase parts, which make reactive oxygen.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNADPH oxidase subunit levels
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In db/db diabetic mice, SS31 suppressed CD36 expression.

    In plain wordsIn diabetic mice, SS31 lowered levels of the CD36 receptor.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCD36 expression
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In db/db diabetic mice, SS31 suppressed NF-κB p65.

    In plain wordsIn diabetic mice, SS31 lowered the inflammation signal NF-κB p65.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNF-κB p65 level
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In db/db diabetic mice, SS31 activated MnSOD.

    In plain wordsIn diabetic mice, SS31 raised the activity of the antioxidant enzyme MnSOD.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMnSOD activity
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In db/db diabetic mice, SS31 activated catalase (CAT).

    In plain wordsIn diabetic mice, SS31 raised the activity of the antioxidant enzyme catalase.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCatalase activity
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    3 mg/kg/day · intraperitoneal · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    Eight-week-old db/m mice and db/db mice were administered with SS31 (3 mg/kg/day) for 12 weeks by intraperitoneal injection.
  11. 11LabIn vitro (cells)Mechanism

    In high glucose-cultured HK-2 cells, SS31 suppressed oxidative stress.

    In plain wordsIn cells, SS31 lowered signs of oxidative stress caused by high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress level
    Study

    n: not reported in source

    high glucose-induced HK-2 cells
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    For the in vitro studies, HG-cultured HK-2 cells were used.
  12. 12LabIn vitro (cells)Mechanism

    In high glucose-cultured HK-2 cells, SS31 suppressed the levels of NADPH oxidase subunits.

    In plain wordsIn cells, SS31 lowered levels of NADPH oxidase parts under high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNADPH oxidase subunit levels
    Study

    n: not reported in source

    high glucose-induced HK-2 cells
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    For the in vitro studies, HG-cultured HK-2 cells were used.
  13. 13LabIn vitro (cells)Mechanism

    In high glucose-cultured HK-2 cells, SS31 suppressed CD36 expression.

    In plain wordsIn cells, SS31 lowered levels of the CD36 receptor under high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCD36 expression
    Study

    n: not reported in source

    high glucose-induced HK-2 cells
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    For the in vitro studies, HG-cultured HK-2 cells were used.
  14. 14LabIn vitro (cells)Mechanism

    In high glucose-cultured HK-2 cells, SS31 suppressed NF-κB p65.

    In plain wordsIn cells, SS31 lowered the inflammation signal NF-κB p65 under high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNF-κB p65 level
    Study

    n: not reported in source

    high glucose-induced HK-2 cells
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    For the in vitro studies, HG-cultured HK-2 cells were used.
  15. 15LabIn vitro (cells)Mechanism

    In high glucose-cultured HK-2 cells, SS31 activated MnSOD.

    In plain wordsIn cells, SS31 raised the activity of the antioxidant enzyme MnSOD under high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMnSOD activity
    Study

    n: not reported in source

    high glucose-induced HK-2 cells
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    For the in vitro studies, HG-cultured HK-2 cells were used.
  16. 16LabIn vitro (cells)Mechanism

    In high glucose-cultured HK-2 cells, SS31 activated catalase (CAT).

    In plain wordsIn cells, SS31 raised the activity of the antioxidant enzyme catalase under high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCatalase activity
    Study

    n: not reported in source

    high glucose-induced HK-2 cells
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 suppressed the levels of oxidative stress, NADPH oxidase subunits, CD36 and NF-κB p65, and activated MnSOD and CAT in db/db mice and HG-induced HK-2 cells.
    1 context sentence
    Summary · context
    For the in vitro studies, HG-cultured HK-2 cells were used.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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