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Study · Animal study (in vivo) · pig · 2012

9 results

A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis.

Eirin A, Li Z, Zhang X, Krier JD, Woollard JR, Zhu XY, Tang H, Herrmann SM, Lerman A, Textor SC, Lerman LO

Hypertension (Dallas, Tex. : 1979)8 Oct 2012Cited by 109 (Europe PMC)

PMID23045468 (opens in a new tab)DOI10.1161/hypertensionaha.112.199919 (opens in a new tab)PepBankPUB-23045468
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In swine with renal artery stenosis undergoing PTRA, Bendavia did not immediately affect inflammatory cytokine levels.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia did not change inflammatory signals right after the procedure.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeInflammatory cytokine levels immediately after PTRA
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Source sentences

    Summary
    Bendavia did not immediately affect inflammatory cytokine levels, yet 4 weeks later, stenotic kidney renal blood flow and glomerular filtration rate both improved (44.00 ± 0.21% and 36.40 ± 10.21%, respectively) in ARAS+PTRA+Bendavia compared with ARAS+PTRA+vehicle.
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In swine with renal artery stenosis, stenotic kidney renal blood flow improved by 44.00% with Bendavia versus vehicle after PTRA.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia improved blood flow in the narrowed kidney compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseStenotic kidney renal blood flow at 4 weeks
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Measurements

    Renal blood flow improvement
    44%
    ARAS+PTRA+Bendavia vs vehicle

    Source sentences

    Summary
    yet 4 weeks later, stenotic kidney renal blood flow and glomerular filtration rate both improved (44.00 ± 0.21% and 36.40 ± 10.21%, respectively) in ARAS+PTRA+Bendavia compared with ARAS+PTRA+vehicle
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In swine with renal artery stenosis, stenotic kidney glomerular filtration rate improved by 36.40% with Bendavia versus vehicle after PTRA.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia improved the filtering rate of the narrowed kidney compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseStenotic kidney glomerular filtration rate at 4 weeks
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Measurements

    GFR improvement
    36.4%
    ARAS+PTRA+Bendavia vs vehicle

    Source sentences

    Summary
    yet 4 weeks later, stenotic kidney renal blood flow and glomerular filtration rate both improved (44.00 ± 0.21% and 36.40 ± 10.21%, respectively) in ARAS+PTRA+Bendavia compared with ARAS+PTRA+vehicle
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In swine with renal artery stenosis, renal mitochondrial biogenesis was restored after PTRA with Bendavia.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia restored the making of new mitochondria in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal mitochondrial biogenesis
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Source sentences

    Summary
    Renal mitochondrial biogenesis was restored after PTRA+Bendavia, and microvascular rarefaction, apoptosis, oxidative stress, tubular injury, and fibrosis decreased.
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In swine with renal artery stenosis, microvascular rarefaction decreased after PTRA with Bendavia.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia reduced the loss of small blood vessels in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal microvascular rarefaction
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Source sentences

    Summary
    Renal mitochondrial biogenesis was restored after PTRA+Bendavia, and microvascular rarefaction, apoptosis, oxidative stress, tubular injury, and fibrosis decreased.
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In swine with renal artery stenosis, renal apoptosis decreased after PTRA with Bendavia.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia reduced programmed cell death in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal apoptosis
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Cell viability and death · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Source sentences

    Summary
    Renal mitochondrial biogenesis was restored after PTRA+Bendavia, and microvascular rarefaction, apoptosis, oxidative stress, tubular injury, and fibrosis decreased.
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In swine with renal artery stenosis, renal oxidative stress decreased after PTRA with Bendavia.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia reduced oxidative stress in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal oxidative stress
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Source sentences

    Summary
    Renal mitochondrial biogenesis was restored after PTRA+Bendavia, and microvascular rarefaction, apoptosis, oxidative stress, tubular injury, and fibrosis decreased.
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In swine with renal artery stenosis, tubular injury decreased after PTRA with Bendavia.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia reduced damage to kidney tubules.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal tubular injury
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Source sentences

    Summary
    Renal mitochondrial biogenesis was restored after PTRA+Bendavia, and microvascular rarefaction, apoptosis, oxidative stress, tubular injury, and fibrosis decreased.
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In swine with renal artery stenosis, renal fibrosis decreased after PTRA with Bendavia.

    In plain wordsIn pigs with kidney artery narrowing, Bendavia reduced scarring in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal fibrosis
    Study

    pign: not reported in source

    Swine atherosclerotic renal artery stenosis with PTRA
    Comparator
    Vehicle
    Outcome group
    Organ injury · Kidney and urinary
    Studied dose
    0.05 mg/kg · intravenous · 4 hoursAs given in this study (pig).

    Source sentences

    Summary
    Renal mitochondrial biogenesis was restored after PTRA+Bendavia, and microvascular rarefaction, apoptosis, oxidative stress, tubular injury, and fibrosis decreased.
    2 context sentences
    Summary · context
    Pigs were treated after 6 weeks of ARAS or control with PTRA+stenting (or sham), adjunct continuous 4-hour infusion of Bendavia (0.05 mg/kg IV) or vehicle (n=7 each) during PTRA.
    Summary · context
    Single-kidney renal blood flow and glomerular filtration rate were studied 4 weeks later and renal mitochondrial biogenesis, microvascular architecture, and injurious pathways evaluated ex vivo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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