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Study · Animal study (in vivo) · 2008

4 results

A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.

Mizuguchi Y, Chen J, Seshan SV, Poppas DP, Szeto HH, Felsen D

American journal of physiology. Renal physiology10 Sept 2008Cited by 61 (Europe PMC)

PMID18784263 (opens in a new tab)PMCIDPMC2584902 (opens in a new tab)DOI10.1152/ajprenal.00395.2007 (opens in a new tab)PepBankPUB-18784263
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a 14-day unilateral ureteral obstruction model, SS‑31 at 1 and 3 mg/kg significantly attenuated all examined aspects of renal damage compared with saline.

    In plain wordsIn animals with a blocked ureter, SS‑31 reduced kidney damage compared with saline, at both 1 and 3 mg/kg.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal damage in obstruction (all aspects examined)
    Study

    n: not reported in source

    14-day unilateral ureteral obstruction (UUO) model
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1 or 3 mg/kg · 14 daysAs given in this study.

    Source sentences

    Summary
    SS-31 significantly attenuated the effects of obstruction on all aspects of renal damage which were examined, with both the 1 and 3 mg/kg doses showing efficacy.
    1 context sentence
    Summary · context
    We therefore used SS-31, a prototype of these peptides, and assessed its effects on renal damage and oxidative stress in a 14-day obstruction model. SS-31 (1 or 3 mg/kg) or saline was given 1 day before and throughout the 14 days of obstruction.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a 14-day unilateral ureteral obstruction model, SS‑31 decreased renal tubular apoptosis compared with saline.

    In plain wordsIn animals with a blocked ureter, SS‑31 reduced death of kidney tubule cells compared with saline.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal tubular apoptosis
    Study

    n: not reported in source

    14-day unilateral ureteral obstruction (UUO) model
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1 or 3 mg/kg · 14 daysAs given in this study.

    Source sentences

    Title
    A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.
    2 context sentences
    Summary · context
    SS-31 significantly attenuated the effects of obstruction on all aspects of renal damage which were examined, with both the 1 and 3 mg/kg doses showing efficacy.
    Summary · context
    We therefore used SS-31, a prototype of these peptides, and assessed its effects on renal damage and oxidative stress in a 14-day obstruction model. SS-31 (1 or 3 mg/kg) or saline was given 1 day before and throughout the 14 days of obstruction.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In a 14-day unilateral ureteral obstruction model, SS‑31 attenuated the increased oxidative stress seen in obstruction.

    In plain wordsIn animals with a blocked ureter, SS‑31 reduced the rise in oxidative stress in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress in obstructed kidney
    Study

    n: not reported in source

    14-day unilateral ureteral obstruction (UUO) model
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1 or 3 mg/kg · 14 daysAs given in this study.

    Source sentences

    Summary
    We noted increased oxidative stress in obstruction, which was also attenuated by SS-31 treatment.
    1 context sentence
    Summary · context
    We therefore used SS-31, a prototype of these peptides, and assessed its effects on renal damage and oxidative stress in a 14-day obstruction model. SS-31 (1 or 3 mg/kg) or saline was given 1 day before and throughout the 14 days of obstruction.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In a 14-day unilateral ureteral obstruction model, SS‑31 treatment affected signaling via the NF-kappaB and p38 MAPK pathways; the direction is not stated.

    In plain wordsIn animals with a blocked ureter, SS‑31 changed two cell-signaling pathways involved in inflammation; the abstract does not give the direction.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedNF-kappaB and p38 MAPK signaling
    Study

    n: not reported in source

    14-day unilateral ureteral obstruction (UUO) model
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    1 or 3 mg/kg · 14 daysAs given in this study.

    Source sentences

    Summary
    Signaling via NF-kappaB and p38 MAPK pathways were both affected by SS-31 treatment.
    1 context sentence
    Summary · context
    We therefore used SS-31, a prototype of these peptides, and assessed its effects on renal damage and oxidative stress in a 14-day obstruction model. SS-31 (1 or 3 mg/kg) or saline was given 1 day before and throughout the 14 days of obstruction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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