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Study · Animal study (in vivo) · rat · 2014

7 results

Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis.

Liu S, Soong Y, Seshan SV, Szeto HH

American journal of physiology. Renal physiology19 Feb 2014Cited by 96 (Europe PMC)

PMID24553434 (opens in a new tab)DOI10.1152/ajprenal.00697.2013 (opens in a new tab)PepBankPUB-24553434
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with renal ischemia, SS‑31 prevented mitochondrial swelling in endothelial and epithelial cells.

    In plain wordsIn rats with kidney ischemia, SS‑31 prevented mitochondria in kidney cells from swelling.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial swelling after ischemia
    Study

    ratn: not reported in source

    Rat renal ischemia-reperfusion (45-min ischemia)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented mitochondria swelling and protected cristae membranes in both endothelial and epithelial cells.
    1 context sentence
    Summary · context
    We found mitochondrial swelling and loss of cristae membranes in endothelial and medullary tubular epithelial cells after 45-min ischemia in the rat.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with renal ischemia, SS‑31 protected cristae membranes in endothelial and epithelial cells.

    In plain wordsIn rats with kidney ischemia, SS‑31 protected the inner mitochondrial membranes in kidney cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial cristae membrane protection
    Study

    ratn: not reported in source

    Rat renal ischemia-reperfusion (45-min ischemia)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented mitochondria swelling and protected cristae membranes in both endothelial and epithelial cells.
    1 context sentence
    Summary · context
    We found mitochondrial swelling and loss of cristae membranes in endothelial and medullary tubular epithelial cells after 45-min ischemia in the rat.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with renal ischemia, SS‑31 prevented no-reflow after ischemia.

    In plain wordsIn rats with kidney ischemia, SS‑31 prevented blood flow from failing to return after the blockage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNo-reflow after ischemia
    Study

    ratn: not reported in source

    Rat renal ischemia-reperfusion (45-min ischemia)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented "no-reflow" after ischemia and significantly reduced the loss of peritubular capillaries and cortical arterioles, interstitial inflammation, and fibrosis at 4 wk after ischemia.
    1 context sentence
    Summary · context
    We found mitochondrial swelling and loss of cristae membranes in endothelial and medullary tubular epithelial cells after 45-min ischemia in the rat.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with renal ischemia, SS‑31 significantly reduced the loss of peritubular capillaries at 4 weeks after ischemia.

    In plain wordsIn rats with kidney ischemia, SS‑31 reduced the loss of small kidney blood vessels four weeks later.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLoss of peritubular capillaries
    Study

    ratn: not reported in source

    Rat renal ischemia-reperfusion (45-min ischemia)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    significantly reduced the loss of peritubular capillaries and cortical arterioles, interstitial inflammation, and fibrosis at 4 wk after ischemia.
    1 context sentence
    Summary · context
    We found mitochondrial swelling and loss of cristae membranes in endothelial and medullary tubular epithelial cells after 45-min ischemia in the rat.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with renal ischemia, SS‑31 significantly reduced the loss of cortical arterioles at 4 weeks after ischemia.

    In plain wordsIn rats with kidney ischemia, SS‑31 reduced the loss of small kidney arteries four weeks later.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLoss of cortical arterioles
    Study

    ratn: not reported in source

    Rat renal ischemia-reperfusion (45-min ischemia)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    significantly reduced the loss of peritubular capillaries and cortical arterioles, interstitial inflammation, and fibrosis at 4 wk after ischemia.
    1 context sentence
    Summary · context
    We found mitochondrial swelling and loss of cristae membranes in endothelial and medullary tubular epithelial cells after 45-min ischemia in the rat.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with renal ischemia, SS‑31 significantly reduced interstitial inflammation at 4 weeks after ischemia.

    In plain wordsIn rats with kidney ischemia, SS‑31 reduced inflammation in kidney tissue four weeks later.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInterstitial inflammation
    Study

    ratn: not reported in source

    Rat renal ischemia-reperfusion (45-min ischemia)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    significantly reduced the loss of peritubular capillaries and cortical arterioles, interstitial inflammation, and fibrosis at 4 wk after ischemia.
    1 context sentence
    Summary · context
    We found mitochondrial swelling and loss of cristae membranes in endothelial and medullary tubular epithelial cells after 45-min ischemia in the rat.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with renal ischemia, SS‑31 significantly reduced fibrosis at 4 weeks after ischemia.

    In plain wordsIn rats with kidney ischemia, SS‑31 reduced kidney scarring four weeks later.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal fibrosis
    Study

    ratn: not reported in source

    Rat renal ischemia-reperfusion (45-min ischemia)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    significantly reduced the loss of peritubular capillaries and cortical arterioles, interstitial inflammation, and fibrosis at 4 wk after ischemia.
    1 context sentence
    Summary · context
    We found mitochondrial swelling and loss of cristae membranes in endothelial and medullary tubular epithelial cells after 45-min ischemia in the rat.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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