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Study · Animal study (in vivo) · mouse · 2020

6 results

Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease.

Miyamoto S, Zhang G, Hall D, Oates PJ, Maity S, Madesh M, Han X, Sharma K

The Journal of biological chemistry10 Apr 2020Cited by 49 (Europe PMC)

PMID32277051 (opens in a new tab)PMCIDPMC7247302 (opens in a new tab)DOI10.1074/jbc.ra119.011110 (opens in a new tab)PepBankPUB-32277051
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Summary

Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstrated that humans with DKD have significantly reduced levels of mitochondrion-derived metabolites in their urine. Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal superoxide production and ameliorating DKD. We found that 18-week-old db/db mice have reduced renal and cardiac superoxide levels, as measured by dihydroethidium oxidation, and increased levels of albuminuria, mesangial matrix accumulation, and urinary H2O2 Administration of MTP-131 significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice. MTP-131 also reduced total renal lysocardiolipin and major lysocardiolipin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice. These results indicate that, in type 2 diabetes, DKD is associated with reduced renal and cardiac superoxide levels and that MTP-131 protects against DKD and preserves physiological superoxide levels, possibly by regulating cardiolipin remodeling.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice, MTP-131 (elamipretide) inhibited the increase in albuminuria.

    In plain wordsIn diabetic mice, elamipretide limited the rise in urine albumin, a sign of kidney damage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAlbuminuria
    Study

    mousen: not reported in source

    db/db mouse (type 2 diabetes, diabetic kidney disease)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MTP-131 significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice.
    1 context sentence
    Summary · context
    Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal superoxide production and ameliorating DKD.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice, MTP-131 (elamipretide) inhibited the increase in urinary H2O2.

    In plain wordsIn diabetic mice, elamipretide limited the rise in urinary hydrogen peroxide.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseUrinary H2O2
    Study

    mousen: not reported in source

    db/db mouse (type 2 diabetes, diabetic kidney disease)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MTP-131 significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice.
    1 context sentence
    Summary · context
    Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal superoxide production and ameliorating DKD.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice, MTP-131 (elamipretide) inhibited the increase in mesangial matrix accumulation.

    In plain wordsIn diabetic mice, elamipretide limited build-up of matrix in the kidney filter.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMesangial matrix accumulation
    Study

    mousen: not reported in source

    db/db mouse (type 2 diabetes, diabetic kidney disease)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MTP-131 significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice.
    1 context sentence
    Summary · context
    Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal superoxide production and ameliorating DKD.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In db/db mice, MTP-131 (elamipretide) fully preserved renal superoxide production, which was reduced in untreated db/db mice.

    In plain wordsIn diabetic mice, elamipretide kept kidney superoxide levels from falling.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal superoxide production
    Study

    mousen: not reported in source

    db/db mouse (type 2 diabetes, diabetic kidney disease)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MTP-131 significantly inhibited increases in albuminuria, urinary H2O2, and mesangial matrix accumulation in db/db mice and fully preserved levels of renal superoxide production in these mice.
    2 context sentences
    Summary · context
    We found that 18-week-old db/db mice have reduced renal and cardiac superoxide levels, as measured by dihydroethidium oxidation, and increased levels of albuminuria, mesangial matrix accumulation
    Summary · context
    Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal superoxide production and ameliorating DKD.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In db/db mice, MTP-131 (elamipretide) reduced total renal lysocardiolipin and major lysocardiolipin subspecies.

    In plain wordsIn diabetic mice, elamipretide lowered kidney lysocardiolipin levels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTotal renal lysocardiolipin
    Study

    mousen: not reported in source

    db/db mouse (type 2 diabetes, diabetic kidney disease)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 also reduced total renal lysocardiolipin and major lysocardiolipin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice.
    1 context sentence
    Summary · context
    Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal superoxide production and ameliorating DKD.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In db/db mice, MTP-131 (elamipretide) preserved lysocardiolipin acyltransferase 1 expression.

    In plain wordsIn diabetic mice, elamipretide kept levels of a cardiolipin-remodelling enzyme from falling.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLysocardiolipin acyltransferase 1 expression
    Study

    mousen: not reported in source

    db/db mouse (type 2 diabetes, diabetic kidney disease)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 also reduced total renal lysocardiolipin and major lysocardiolipin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice.
    1 context sentence
    Summary · context
    Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal superoxide production and ameliorating DKD.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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