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Study · Animal study (in vivo) · rabbit · 2014

7 results

Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia.

Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA

Journal of cardiovascular pharmacology and therapeutics28 Nov 2013Cited by 92 (Europe PMC)

PMID24288396 (opens in a new tab)PMCIDPMC4103197 (opens in a new tab)DOI10.1177/1074248413508003 (opens in a new tab)PepBankPUB-24288396
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with ischemia/reperfusion, Bendavia given 20 minutes before reperfusion reduced myocardial infarct size by about 50%.

    In plain wordsIn rabbits, Bendavia given 20 minutes before reperfusion cut the size of the heart attack damage by about half.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial infarct size, given 20 minutes before reperfusion
    Study

    rabbitn: not reported in source

    In vivo ischemia/reperfusion (30/180 min)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    0.05 mg/kg/h · intravenous · 1 or 3 hours of reperfusionAs given in this study (rabbit).

    Measurements

    Infarct size reduction
    ≈ 50%
    Bendavia 20 min before reperfusion

    Source sentences

    Summary
    In rabbits exposed to in vivo ischemia/reperfusion (30/180 min), Bendavia administered 20 minutes prior to reperfusion (0.05 mg/kg/h, intravenously) reduced myocardial infarct size by ∼50% when administered for either 1 or 3 hours of reperfusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with ischemia/reperfusion, protection against infarction was completely lost when Bendavia began 10 minutes after the onset of reperfusion.

    In plain wordsIn rabbits, Bendavia gave no protection against heart attack damage when started 10 minutes after blood flow returned.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeInfarct size, Bendavia started 10 minutes after reperfusion onset
    Study

    rabbitn: not reported in source

    In vivo ischemia/reperfusion (30/180 min)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, when Bendavia perfusion began just 10 minutes after the onset of reperfusion, the protection against infarction and no-reflow was completely lost, indicating that the mechanism of protection is occurring early in reperfusion.
    1 context sentence
    Summary · context
    In rabbits exposed to in vivo ischemia/reperfusion (30/180 min), Bendavia administered 20 minutes prior to reperfusion (0.05 mg/kg/h, intravenously) reduced myocardial infarct size by ∼50% when administered for either 1 or 3 hours of reperfusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with ischemia/reperfusion, protection against no-reflow was completely lost when Bendavia began 10 minutes after the onset of reperfusion.

    In plain wordsIn rabbits, Bendavia gave no protection against no-reflow when started 10 minutes after blood flow returned.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeNo-reflow, Bendavia started 10 minutes after reperfusion onset
    Study

    rabbitn: not reported in source

    In vivo ischemia/reperfusion (30/180 min)
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, when Bendavia perfusion began just 10 minutes after the onset of reperfusion, the protection against infarction and no-reflow was completely lost, indicating that the mechanism of protection is occurring early in reperfusion.
    1 context sentence
    Summary · context
    In rabbits exposed to in vivo ischemia/reperfusion (30/180 min), Bendavia administered 20 minutes prior to reperfusion (0.05 mg/kg/h, intravenously) reduced myocardial infarct size by ∼50% when administered for either 1 or 3 hours of reperfusion.
  4. 04LabEx vivo tissueMechanism

    In isolated mouse liver mitochondria, Bendavia had no discernible effect on blocking the permeability transition pore.

    In plain wordsIn lab tests on mouse liver mitochondria, Bendavia did not block the permeability transition pore.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeBlocking of the permeability transition pore
    Study

    mousen: not reported in source

    Isolated liver mitochondria
    Outcome group
    Mitochondrial function · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Experiments in isolated mouse liver mitochondria found no discernible effect of Bendavia on blocking the permeability transition pore
  5. 05LabEx vivo tissueMechanism

    In isolated heart mitochondria, Bendavia had no effect on respiratory rates.

    In plain wordsIn lab tests on heart mitochondria, Bendavia did not change how fast they used oxygen.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeMitochondrial respiratory rates
    Study

    n: not reported in source

    Isolated heart mitochondria
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    studies in isolated heart mitochondria showed no effect of Bendavia on respiratory rates.
  6. 06LabEx vivo tissueMechanism

    In isolated heart mitochondria, Bendavia significantly lowered reactive oxygen species levels.

    In plain wordsIn lab tests on heart mitochondria, Bendavia lowered levels of reactive oxygen species.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseReactive oxygen species levels in heart mitochondria
    Study

    n: not reported in source

    Isolated heart mitochondria
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    As Bendavia significantly lowered reactive oxygen species (ROS) levels in isolated heart mitochondria
  7. 07LabIn vitro (cell-free)Activity measurement

    In cell-free systems that generate reactive oxygen species, Bendavia showed no discernible scavenging across 1 nmol/L to 1 mmol/L, unlike prototypical scavengers.

    In plain wordsIn lab tests without cells, Bendavia did not scavenge reactive oxygen species, unlike known scavengers.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeROS-scavenging capacity
    Study

    n: not reported in source

    Enzymatic ROS-generating cell-free systems
    Outcome group
    Oxidative stress · Pharmacology
    Studied dose
    1 nmol/L to 1 mmol/LAs given in this study.

    Source sentences

    Summary
    Across doses ranging from 1 nmol/L to 1 mmol/L, Bendavia showed no discernible ROS-scavenging properties, clearly differentiating itself from prototypical scavengers.
    1 context sentence
    Summary · context
    the ROS-scavenging capacity of Bendavia was compared to well-known ROS scavengers using in vitro (cell-free) systems that enzymatically generate ROS.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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