Small molecule · 306.2 Da

Bromantane studies and research data

PepBank has 51 bromantane studies with results. 47 of them gave bromantane, with 284 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.

Searches 284 results and 68 papers. Newer studies from Europe PMC

Results in people

13% of 284 results

Results in animals

223

79% of 284 results

Results in lab cells

9% of 284 results

From computer models

0% of 284 results

The molecule

Bromantane identity

Identifiers, parent molecule, targets and development stage, from curated data.

Bromantane is N-(4-bromophenyl)adamantan-2-amine. Its defined chemical structure has no peptide chain. Russian product information describes Ladasten for asthenic conditions. The archived manufacturer page describes enhanced dopamine synthesis and release and effects on GABA reception. These are pathway claims, not proof of a selective receptor target. Secondary sources report a 2024 replacement registration. Current official status requires national register confirmation.

Kind: Small molecule
Formula: C₁₆H₂₀BrN
Identifiers: ChEMBLCHEMBL4303520 (opens in a new tab)PubChem CID4660557 (opens in a new tab)UNIIN1ILS53XWK (opens in a new tab)CAS87913-26-6
Development: Approved in Russia only (registered as Ladasten / Ладастен)Zakusov Institute of PharmacologyThe archived manufacturer page identifies the Zakusov Institute as developer and LEKKO as manufacturer. It reports Russian registration in 2008. Vidal and a register mirror report replacement registration ЛП-№(005486)-(РГ-RU), dated 16 May 2024. Direct national-register confirmation remains unresolved. Source (opens in a new tab)

Targets

No molecular target is recorded.

Structure

Structure from the identity record.

2D structure

Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).

SMILES fromPubChem CID 4660557(opens in a new tab)

C1C2CC3CC1CC(C2)C3NC4=CC=C(C=C4)Br

Results by area

Bromantane results by year and outcome

Counts are exact and come from studies that gave the peptide.

Studies by year

51 of 68 studies have results (75%), published 1993 to 2015. Top row: every study. Bottom row: studies with results about Bromantane, by class. The rows use different scales.

Studies
Human
Animal
Lab
Computer model
Natural levels, tool or combination only

Studies68 in all, 1993 to 2021

Studies with results51 in all, 1993 to 2015

Retracted studies are left out. A study with results in two classes counts in both.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

Bromantane studies on receptors and cell signals

70 results · people 9 · animals 49 · lab 12

Top 3 of 70 results

In healthy volunteers, bromantan increased alpha brain-wave power compared with placebo.Voenno-meditsinskii zhurnal, 2000
In patients with marked alpha rhythm, ladasten increased high-frequency alpha activity.Eksperimental'naia i klinicheskaia farmakologiia, 2008
In healthy volunteers, bromantan lowered delta brain-wave power compared with placebo.Voenno-meditsinskii zhurnal, 2000

Bromantane studies on daily life and fitness

32 results · people 9 · animals 23 · lab 0

Top 5 of 32 results

In healthy volunteers, bromantan improved functional state compared with placebo.Voenno-meditsinskii zhurnal, 2000
In patients with neurasthenia, ladasten was better than placebo in how fast and how much main asthenic symptoms fell.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2009
In patients with neurasthenia, self-rated ladasten effects were not linked to personal features.Eksperimental'naia i klinicheskaia farmakologiia, 2011
In volunteers, bromantane alone was among the most effective regimens for resistance to combined carbon dioxide and heat exposure.Meditsina truda i promyshlennaia ekologiia, 1993
In patients with psychoautonomic syndrome, quality of life increased during ladasten treatment and remained higher after treatment ended.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010

Bromantane studies on side effects

27 results · people 6 · animals 21 · lab 0

Top 5 of 27 results

In patients with psychoautonomic syndrome, 3% had adverse effects during ladasten treatment.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010
In patients with neurasthenia, the study found no withdrawal syndrome after ladasten treatment ended.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2009
In some rats, high bromantane doses caused regurgitation.Bulletin of experimental biology and medicine, 2002
In rats, liver cells showed increased staining with bromantan treatment.Eksperimental'naia i klinicheskaia farmakologiia, 1999
In some rats, high bromantane doses caused excessive urination.Bulletin of experimental biology and medicine, 2002

Bromantane studies on mood, stress and behavior

19 results · people 6 · animals 13 · lab 0

Top 5 of 19 results

In patients with psychoautonomic syndrome, the study reported that ladasten improved anxiety-depressive disorders.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010
In untired men, bromantan did not change subjective state compared with placebo.Voenno-meditsinskii zhurnal, 2000
In patients with psychogenic asthenic disorder, ladasten showed stimulant effects.Eksperimental'naia i klinicheskaia farmakologiia, 2006
In patients with marked alpha rhythm, ladasten showed predominantly stimulant effects.Eksperimental'naia i klinicheskaia farmakologiia, 2008
In patients with psychogenic asthenic disorder, ladasten showed anxiety-reducing effects.Eksperimental'naia i klinicheskaia farmakologiia, 2006

Bromantane studies on overall treatment results

3 results · people 3 · animals 0 · lab 0

3 results

In patients with psychoautonomic syndrome and asthenia, 76.0% responded on CGI-S during ladasten treatment.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010
In healthy volunteers, ladasten effects were stronger in individuals prone to stress responses.Eksperimental'naia i klinicheskaia farmakologiia, 2009
In patients with psychoautonomic syndrome and asthenia, 90.8% responded on CGI-I during ladasten treatment.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010

Bromantane studies on brain and nerves

30 results · people 1 · animals 29 · lab 0

Top 5 of 30 results

In patients with psychoautonomic syndrome, the study reported that ladasten improved autonomic dystonia.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010
In rats, pup exploratory behavior after maternal bromantan was insignificantly lower than controls.Neurotoxicology and teratology, 2001
In cats under anesthesia, bromantan reduced induced ganglion electrical potential compared with the initial level at specified stimulation frequencies.Eksperimental'naia i klinicheskaia farmakologiia, 2000
In rats, lower bromantane doses stimulated behavioral activity.Bulletin of experimental biology and medicine, 2002
In animals, catecholaminergic effects accounted for bromantan's therapeutic mechanism.Eksperimental'naia i klinicheskaia farmakologiia, 2000

Bromantane studies on memory and thinking

2 results · people 1 · animals 1 · lab 0

2 results

In healthy volunteers with mental fatigue, ladasten improved psychophysiological measures.Eksperimental'naia i klinicheskaia farmakologiia, 2009
In rats, bromantan improved memory processes.Eksperimental'naia i klinicheskaia farmakologiia, 1999

Bromantane studies on sleep

1 result · people 1 · animals 0 · lab 0

1 result

In patients with psychoautonomic syndrome, the study reported that ladasten improved sleep disorders.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010

Bromantane studies on sex hormones and fertility

32 results · people 0 · animals 32 · lab 0

Top 5 of 32 results

In male rats, bromantan produced an unreliable decrease in sperm amount.Eksperimental'naia i klinicheskaia farmakologiia, 2000
In rats, maternal general state did not differ significantly from controls during or after bromantan treatment.Neurotoxicology and teratology, 2001
In pregnant rats, ladasten reduced fetal resorption events.Eksperimental'naia i klinicheskaia farmakologiia, 2012
In rats, maternal activity did not differ significantly from controls during or after bromantan treatment.Neurotoxicology and teratology, 2001
In rats, ladasten increased sperm count.Eksperimental'naia i klinicheskaia farmakologiia, 2005

Bromantane studies on cells, genes and aging

26 results · people 0 · animals 13 · lab 13

Top 5 of 26 results

In rats, overall pup reflex expression after maternal bromantan differed insignificantly from controls.Neurotoxicology and teratology, 2001
In rats, ladasten promoted fetal development before birth.Eksperimental'naia i klinicheskaia farmakologiia, 2012
In rats, bromantan prevented heart-cell mitochondrial changes associated with extreme running.Eksperimental'naia i klinicheskaia farmakologiia, 1998
In rats, bromantan prevented skeletal muscle mitochondrial changes associated with extreme running.Eksperimental'naia i klinicheskaia farmakologiia, 1998
In cells, ladasten enhanced stimulation of human T-lymphocyte multiplication.Eksperimental'naia i klinicheskaia farmakologiia, 2004

Bromantane studies on weight and appetite

11 results · people 0 · animals 11 · lab 0

Top 5 of 11 results

In rats, pups after maternal bromantan gained more weight than controls through postnatal day 35 and again on days 77-112.Neurotoxicology and teratology, 2001
In rats, prolonged large-dose bromantan reduced food intake.Eksperimental'naia i klinicheskaia farmakologiia, 2000
In rats, offspring of ladasten-treated mothers gained more weight after birth.Eksperimental'naia i klinicheskaia farmakologiia, 2012
In rats, ladasten restored body weight disrupted by stress.Eksperimental'naia i klinicheskaia farmakologiia, 2005
In rats, prolonged large-dose bromantan slightly increased drinking.Eksperimental'naia i klinicheskaia farmakologiia, 2000

Bromantane studies on heart and blood vessels

10 results · people 0 · animals 10 · lab 0

Top 3 of 10 results

In rats under anesthesia, bromantan markedly increased blood volume pumped per heartbeat.Eksperimental'naia i klinicheskaia farmakologiia, 2000
In rats, bromantan did not affect cardiovascular functional activation during operant activity.Eksperimental'naia i klinicheskaia farmakologiia, 2000
In rats under anesthesia, bromantan markedly increased blood volume pumped per minute.Eksperimental'naia i klinicheskaia farmakologiia, 2000

Bromantane studies on immune system and inflammation

10 results · people 0 · animals 10 · lab 0

Top 5 of 10 results

In mice with stress-induced depression, ladasten restored immune-organ indexes more strongly than imipramine.Eksperimental'naia i klinicheskaia farmakologiia, 2011
In mice with stress-induced depression, ladasten reduced IL-6 more than imipramine.Eksperimental'naia i klinicheskaia farmakologiia, 2011
In mice under stress, Ladasten restored relative thymus weight to the control level.Bulletin of experimental biology and medicine, 2014
In mice given LPS, ladasten reduced TNF-α more strongly than imipramine.Bulletin of experimental biology and medicine, 2011
In mice under stress, Ladasten restored relative spleen weight to the control level.Bulletin of experimental biology and medicine, 2014

Bromantane studies on autism and child development

3 results · people 0 · animals 3 · lab 0

3 results

In rats, offspring sensorimotor reflexes did not mature significantly faster than controls after parental bromantan exposure.Eksperimental'naia i klinicheskaia farmakologiia, 1999
In rats, pups after low-dose maternal bromantan showed significantly earlier incisor eruption than controls.Neurotoxicology and teratology, 2001
In rats, offspring physical development did not accelerate significantly compared with controls after parental bromantan exposure.Eksperimental'naia i klinicheskaia farmakologiia, 1999

Bromantane studies on sexual and women's health

3 results · people 0 · animals 3 · lab 0

3 results

In rats, acute bromantan increased sexual proceptivity.Eksperimental'naia i klinicheskaia farmakologiia, 2004
In rats, chronic bromantan increased sexual proceptivity as dose increased.Eksperimental'naia i klinicheskaia farmakologiia, 2004
In rats, chronic bromantan increased sexual receptivity as dose increased.Eksperimental'naia i klinicheskaia farmakologiia, 2004

Bromantane studies on lungs and breathing

2 results · people 0 · animals 2 · lab 0

2 results

In rats, high bromantane doses slightly increased breathing rate.Bulletin of experimental biology and medicine, 2002
In rats, high bromantane doses slightly increased breathing depth.Bulletin of experimental biology and medicine, 2002

Bromantane studies on cancer

1 result · people 0 · animals 1 · lab 0

1 result

In mice, antigenic complexes with Bromantan increased protection compared with antigenic complexes alone.Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2001

Bromantane studies on metabolism and nutrition

1 result · people 0 · animals 1 · lab 0

1 result

In rats, rectal temperature decreased after virtually all bromantane doses.Bulletin of experimental biology and medicine, 2002

Bromantane studies on survival and serious illness

1 result · people 0 · animals 1 · lab 0

1 result

In mice, the intraperitoneal bromantan dose lethal to half the animals was 8100 mg/kg.Eksperimental'naia i klinicheskaia farmakologiia, 1999

Trials and papers

Bromantane trials

Registered trials that test the peptide, with phase, status and dates. A dot marks trials with posted results.

StatusPhase

0 trials match. Highest phase first. Data from ClinicalTrials.gov.

No trial matches these filters.

Papers

Studies on this peptide. Some have results. The others have none yet.

Sort

Design

68 studies match. Retracted studies are left out.

Showing 24 of 68 studiesquery qry_6f446eec2c2fa030740537aa

Studies with results

51 studies in all, 17 on this page

Animal study (in vivo) · rat · 2001

33 results

Effects of bromantan on offspring maturation and development of reflexes.

Iezhitsa et al. 2001Neurotoxicology and teratologycited by 14

PMID 11348840DOI 10.1016/s0892-0362(01)00119-2PUB-11348840

Full text at the publisher30 results where Bromantane was given (plus 3 on tools or combinations, listed separately)

Publisher page See results (33)

Ex vivo tissue · rat · 2007

4 results

The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats.

Mikhaylova et al. 2007Neuropharmacologycited by 6

PMID 17854844DOI 10.1016/j.neuropharm.2007.07.001PUB-17854844

Full text at the publisher2 results where Bromantane was given (plus 2 on tools or combinations, listed separately)

Publisher page See results (4)

Animal study (in vivo) · mouse · 2011

5 results

[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].

Tallerova et al. 2011Eksperimental'naia i klinicheskaia farmakologiiacited by 6

PMID 22288152PUB-22288152

Full text at the publisher5 results where Bromantane was given

Publisher page See results (5)

Animal study (in vivo) · mouse · 2011

3 results

Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.

Tallerova et al. 2011Bulletin of experimental biology and medicinecited by 5

PMID 22803040DOI 10.1007/s10517-011-1453-2PUB-22803040

Full text at the publisher3 results where Bromantane was given

Publisher page See results (3)

Animal study (in vivo) · rat · 2000

7 results

[Effect of the long term administration of bromantan on the reproductive function in rats].

Khamidova et al. 2000Eksperimental'naia i klinicheskaia farmakologiiacited by 4

PMID 10934594PUB-10934594

Full text at the publisher7 results where Bromantane was given

Publisher page See results (7)

Animal study (in vivo) · rat · 1995

7 results

[The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain].

Kudrin et al. 1995Eksperimental'naia i klinicheskaia farmakologiiacited by 3

PMID 7580761PUB-07580761

Full text at the publisher7 results where Bromantane was given

Publisher page See results (7)

Animal study (in vivo) · mouse · 2014

4 results

Correcting effect of ladasten on variations in the subpopulation composition of T lymphocytes in C57BL/6 mice on the experimental model of an anxious-depressive state.

Tallerova et al. 2014Bulletin of experimental biology and medicinecited by 3

PMID 24771370DOI 10.1007/s10517-014-2343-1PUB-24771370

Full text at the publisher4 results where Bromantane was given

Publisher page See results (4)

Non-randomized trial · 2008

6 results

[Characteristics of ladasten effect in neurasthenia patients with various EEG parameters].

Neznamov et al. 2008Eksperimental'naia i klinicheskaia farmakologiiacited by 2

PMID 18819436PUB-18819436

Full text at the publisher6 results where Bromantane was given

Publisher page See results (6)

Animal study (in vivo) · rat · 2010

5 results

[Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015].

Davydova et al. 2010Eksperimental'naia i klinicheskaia farmakologiiacited by 2

PMID 20408420PUB-20408420

Full text at the publisher5 results where Bromantane was given

Publisher page See results (5)

Animal study (in vivo) · mouse · 2011

2 results

[Analysis of the binding capacity of the benzodiazepine site of gabaa receptor in mice C57BL/6 and BALB/C pretreated with anxiolytics].

Iarkova et al. 2011Eksperimental'naia i klinicheskaia farmakologiiacited by 2

PMID 22232906PUB-22232906

Full text at the publisher1 result where Bromantane was given

Publisher page See results (2)

Not a test of Bromantane alone · 2012

6 results

[Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types].

Neznamov et al. 2012Eksperimental'naia i klinicheskaia farmakologiiacited by 2

PMID 22834121PUB-22834121

Full text at the publisher6 results where Bromantane was a tool, carrier or part of a combination

Publisher page See results (6)

Non-randomized trial · 1993

2 results

[Experimental rationale for the use of drugs to increase the resistance of the human body to the combined action of carbon monoxide and hyperthermia].

Sedov et al. 1993Meditsina truda i promyshlennaia ekologiiacited by 1

PMID 8087458PUB-08087458

Full text at the publisher1 result where Bromantane was given (plus 1 on tools or combinations, listed separately)

Publisher page See results (2)

Animal study (in vivo) · rat · 1993

5 results

[A quantitative pharmaco-electroencephalographic analysis of the action of bromantane].

Krapivin et al. 1993Biulleten' eksperimental'noi biologii i meditsinycited by 1

PMID 8312546PUB-08312546

Full text at the publisher5 results where Bromantane was given

Publisher page See results (5)

Animal study (in vivo) · cat, mouse and rat · 1999

11 results

[The mechanisms of the neurotropic action of bromantan].

Morozov et al. 1999Eksperimental'naia i klinicheskaia farmakologiiacited by 1

PMID 10198757PUB-10198757

Full text at the publisher11 results where Bromantane was given

Publisher page See results (11)

Animal study (in vivo) · mouse · 1999

4 results

[The effect of bromantane on the behavior of inbred mouse strains with different phenotypes of emotional stress reaction].

Seredenin et al. 1999Eksperimental'naia i klinicheskaia farmakologiiacited by 1

PMID 10439937PUB-10439937

Full text at the publisher4 results where Bromantane was given

Publisher page See results (4)

Animal study (in vivo) · cat and rat · 2000

10 results

[The effect of bromantane on the cardiovascular and sympathetic-adrenal systems in animals].

Morozov et al. 2000Eksperimental'naia i klinicheskaia farmakologiiacited by 1

PMID 10763107PUB-10763107

Full text at the publisher10 results where Bromantane was given

Publisher page See results (10)

Animal study (in vivo) · 2000

2 results

[An acute toxicity study of bromantane].

Bugaeva et al. 2000Eksperimental'naia i klinicheskaia farmakologiiacited by 1

PMID 10763112PUB-10763112

Full text at the publisher2 results where Bromantane was given

Publisher page See results (2)

More studies

10 studies in all, 7 on this page

PubMed tag: Meta-Analysis, Systematic Review · 2021

Plant Adaptogens-History and Future Perspectives.

Todorova et al. 2021Nutrientscited by 62

PMID 34445021PMC8398443DOI 10.3390/nu13082861PUB-34445021

CC BY

Download PDF

PubMed tag: review-article, Review · 2012

The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.

Oliynyk et al. 2012Biomolecules & therapeuticscited by 17

PMID 24009833PMC3762282DOI 10.4062/biomolther.2012.20.5.446PUB-24009833

Rights unknown

Source link

PubMed tag: none · 2015

Ruthenium-catalyzed reductive amination without an external hydrogen source.

Kolesnikov et al. 2015Organic letterscited by 16

PMID 25549756DOI 10.1021/ol503595mPUB-25549756

Full text at the publisher

Publisher page

Indexing hint: Animal study · 1995

[The effect of bromantane, a new immunostimulant with psychostimulating action, on release and metabolism of dopamine in the dorsal striatum of freely moving rats: a microdialysis study].

Grekhova et al. 1995Biulleten' eksperimental'noi biologii i meditsinycited by 2

PMID 7795203PUB-07795203

Full text at the publisher

Publisher page

PubMed tag: Review, Comparative Study · 1999

[Adamantane derivatives enhancing body's resistance to emergencies].

Morozov et al. 1999Vestnik Rossiiskoi akademii meditsinskikh naukcited by 2

PMID 10222828PUB-10222828

Full text at the publisher

Publisher page

PubMed tag: Comparative Study · 1998

[Comparative analysis of effects of adapromine, midantan, and bromantane on the bioelectric activity of the rat brain].

Krapivin et al. 1998Biulleten' eksperimental'noi biologii i meditsinycited by 1

PMID 9559131DOI 10.1007/bf02496852PUB-09559131

Full text at the publisher

Publisher page

Indexing hint: Animal study · 1999

[Analysis of pharmacological properties of bromantane].

Seredenin et al. 1999Biulleten' eksperimental'noi biologii i meditsinycited by 1

PMID 10640239PUB-10640239

Full text at the publisher

Publisher page

No result for Bromantane (1 study on this page, 7 in all)

These studies name Bromantane but give no result for it (for example, the results concern another peptide in the study).

Indexing hint: Animal study · 2016

[STUDYING SOME PHARMACOLOGICAL EFFECTS OF NEW 3-HYDROXYPYRIDINE DERIVATIVE].

Yasnetsov et al. 2016Eksperimental'naia i klinicheskaia farmakologiiacited by 2

PMID 27416675PUB-27416675

Full text at the publisher

Publisher page

Newer studies

PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.

Bromantane studies: 51 papers with results

Page 1 of 2

[Ladasten, the new drug with psychostimulant and anxiolytic actions in treatment of neurasthenia (results of the comparative clinical study with placebo)].
Neznamov GG · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2009
Randomized controlled trial · 2 results
[Treatment of asthenic disorders in patients with psychoautonomic syndrome: results of a multicenter study on efficacy and safety of ladasten].
Voznesenskaia TG · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2010
Non-randomized trial · 10 results
[The neuro- and psychophysiological effects of bromantane].
Viatleva OA · Voenno-meditsinskii zhurnal · 2000
Non-randomized trial · 8 results
[Characteristics of ladasten effect in neurasthenia patients with various EEG parameters].
Neznamov GG · Eksperimental'naia i klinicheskaia farmakologiia · 2008
Non-randomized trial · 6 results
[Experimental rationale for the use of drugs to increase the resistance of the human body to the combined action of carbon monoxide and hyperthermia].
Sedov AV · Meditsina truda i promyshlennaia ekologiia · 1993
Non-randomized trial · 2 results
[Self-evaluation of single test doses and objective indices of ladasten vs. placebo efficacy in neurasthenic patients].
Reutova MA · Eksperimental'naia i klinicheskaia farmakologiia · 2011
Non-randomized trial · 3 results
[Effect of ladasten on the psychophysiological parameters of healthy volunteers].
Bogdan NG · Eksperimental'naia i klinicheskaia farmakologiia · 2009
Non-randomized trial · 3 results
[Pilot clinical trial of ladasten].
Siuniakov SA · Eksperimental'naia i klinicheskaia farmakologiia · 2006
Non-randomized trial · 3 results
Effects of bromantan on offspring maturation and development of reflexes.
Iezhitsa IN · Neurotoxicology and teratology · 2001
Animal study (in vivo) · rat · 33 results
[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].
Tallerova AV · Eksperimental'naia i klinicheskaia farmakologiia · 2011
Animal study (in vivo) · mouse · 5 results
Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.
Tallerova AV · Bulletin of experimental biology and medicine · 2011
Animal study (in vivo) · mouse · 3 results
[Effect of the long term administration of bromantan on the reproductive function in rats].
Khamidova TV · Eksperimental'naia i klinicheskaia farmakologiia · 2000
Animal study (in vivo) · rat · 7 results
Correcting effect of ladasten on variations in the subpopulation composition of T lymphocytes in C57BL/6 mice on the experimental model of an anxious-depressive state.
Tallerova AV · Bulletin of experimental biology and medicine · 2014
Animal study (in vivo) · mouse · 4 results
[The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain].
Kudrin VS · Eksperimental'naia i klinicheskaia farmakologiia · 1995
Animal study (in vivo) · rat · 7 results
[Analysis of the binding capacity of the benzodiazepine site of gabaa receptor in mice C57BL/6 and BALB/C pretreated with anxiolytics].
Iarkova MA · Eksperimental'naia i klinicheskaia farmakologiia · 2011
Animal study (in vivo) · mouse · 2 results
[Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015].
Davydova AI · Eksperimental'naia i klinicheskaia farmakologiia · 2010
Animal study (in vivo) · rat · 5 results
[Cytosine demethylation in the tyrosine hydroxylase gene promoter in the hypothalamus cells of the rat brain under the action of an aminoadamantane derivative Ladasten].
Vakhitova IuV · Genetika · 2006
Animal study (in vivo) · rat · 1 result
[The effect of ladasten on the activity of cAMP-dependent protein kinases and the phosphorylation of proteins in brain cells of rats].
Vakhitova IuV · Eksperimental'naia i klinicheskaia farmakologiia · 2004
Animal study (in vivo) · rat · 3 results
[Effect of ladasten on the proteinase C activity in the rat brain cells].
Vakhitova IuV · Eksperimental'naia i klinicheskaia farmakologiia · 2004
Animal study (in vivo) · rat · 5 results
Toxic effect of single treatment with bromantane on neurological status of experimental animals.
Iezhitsa IN · Bulletin of experimental biology and medicine · 2002
Animal study (in vivo) · rat · 20 results
[The effect of bromantane on the cardiovascular and sympathetic-adrenal systems in animals].
Morozov IS · Eksperimental'naia i klinicheskaia farmakologiia · 2000
Animal study (in vivo) · cat and rat · 10 results
[An acute toxicity study of bromantane].
Bugaeva LI · Eksperimental'naia i klinicheskaia farmakologiia · 2000
Animal study (in vivo) · 2 results
[The effect of bromantane on the behavior of inbred mouse strains with different phenotypes of emotional stress reaction].
Seredenin SB · Eksperimental'naia i klinicheskaia farmakologiia · 1999
Animal study (in vivo) · mouse · 4 results
[The mechanisms of the neurotropic action of bromantan].
Morozov IS · Eksperimental'naia i klinicheskaia farmakologiia · 1999
Animal study (in vivo) · cat, mouse and rat · 11 results
[A quantitative pharmaco-electroencephalographic analysis of the action of bromantane].
Krapivin SV · Biulleten' eksperimental'noi biologii i meditsiny · 1993
Animal study (in vivo) · rat · 5 results
[Effect of ladasten on antenatal and postnatal development].
Bugaeva LI · Eksperimental'naia i klinicheskaia farmakologiia · 2012
Animal study (in vivo) · rat · 4 results
Time course of histone deacetylase 1 and acetylated H3 and H4 histones in the brain of rats treated with ladasten.
Salimgareeva MKh · Bulletin of experimental biology and medicine · 2011
Animal study (in vivo) · rat · 4 results
Proteomic analysis and identification of ladasten target proteins in rat brain.
Yamidanov RS · Bulletin of experimental biology and medicine · 2010
Animal study (in vivo) · rat · 1 result
[Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb].
Zimin IA · Eksperimental'naia i klinicheskaia farmakologiia · 2010
Animal study (in vivo) · rat · 11 results
Changes in CREB (SER133) content and DNA-binding activity of transcriptional factors in rat brain cells against the background of ladasten exposure.
Salimgareeva MKh · Bulletin of experimental biology and medicine · 2009
Animal study (in vivo) · rat · 1 result
[Comparative study of the effect of Ladasten, Sydnocarb and their combination on physical work ability of laboratory animals].
Levina MN · Eksperimental'naia i klinicheskaia farmakologiia · 2006
Animal study (in vivo) · mouse · 2 results
[Studying the mechanisms of ladasten action].
Iarkova MA · Eksperimental'naia i klinicheskaia farmakologiia · 2005
Animal study (in vivo) · rat · 3 results
[Effect of ladasten on reproduction function in male rats].
Khamidova TV · Eksperimental'naia i klinicheskaia farmakologiia · 2005
Animal study (in vivo) · rat · 6 results
[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound].
Vakhitova IuV · Molekuliarnaia biologiia · 2005
Animal study (in vivo) · rat · 2 results
Psychotropic effects of sidnocarb and ladasten in inbred mice with different reaction to emotional stress.
Levina MN · Bulletin of experimental biology and medicine · 2005
Animal study (in vivo) · mouse · 4 results
[Ladasten induces the expression of genes regulating dopamine biosynthesis in various structures of rat brain].
Vakhitova IuV · Eksperimental'naia i klinicheskaia farmakologiia · 2004
Animal study (in vivo) · rat · 4 results
[The effect of bromantan on the sexual behavior and conception in rats].
Kuzubova EA · Eksperimental'naia i klinicheskaia farmakologiia · 2004
Animal study (in vivo) · rat · 3 results
[Immunotropic and immunogenic properties of Burkholderia pseudomallei surface and membrane antigens].
Piven' NN · Zhurnal mikrobiologii, epidemiologii i immunobiologii · 2001
Animal study (in vivo) · mouse · 1 result
[Effect of bromantane on the rat neurologic status in two month course].
Iëzhitsa IN · Eksperimental'naia i klinicheskaia farmakologiia · 2000
Animal study (in vivo) · rat · 18 results
[Effects of bromantane and sidnocarb on long-term operant conditioning and its vegetative correlates in rats].
Morozov IS · Eksperimental'naia i klinicheskaia farmakologiia · 2000
Animal study (in vivo) · rat · 5 results
[The effect of the actoprotector preparation bromantane on the postnatal development of rat pups].
Iëzhitsa IN · Eksperimental'naia i klinicheskaia farmakologiia · 1999
Animal study (in vivo) · rat · 18 results
[The effect of bromantane on the erythro- and leukocytic profile of the peripheral blood in rats].
Bugaeva LI · Eksperimental'naia i klinicheskaia farmakologiia · 1999
Animal study (in vivo) · rat · 14 results
[The characteristics of the neuropsychotropic activity of bromantane in laboratory animals].
Morozov IS · Eksperimental'naia i klinicheskaia farmakologiia · 1999
Animal study (in vivo) · mouse and rat · 7 results
[The effect of bromantane on the physical work capacity of laboratory animals].
Morozov IS · Eksperimental'naia i klinicheskaia farmakologiia · 1998
Animal study (in vivo) · mouse and rat · 6 results
The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats.
Mikhaylova M · Neuropharmacology · 2007
Ex vivo tissue · rat · 4 results
[The effect of ladasten on the activation-induced expression of Fas receptor on T-lymphocytes and their sensitivity to Fas-induced apoptosis].
Vakhitova IuV · Eksperimental'naia i klinicheskaia farmakologiia · 2004
In vitro (cells) · 4 results
[Effect of ladasten on proliferative activity and apoptosis in peripheral blood T-lymphocytes ].
Vakhitova IuV · Eksperimental'naia i klinicheskaia farmakologiia · 2002
In vitro (cells) · 9 results
[Possibilities of the pharmacological correction of adaptive reactions of human organism in short-term moving from middle to high altitude].
Kundashev UK · Eksperimental'naia i klinicheskaia farmakologiia · 2014
Not a test of Bromantane alone · 7 results
[Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types].
Neznamov GG · Eksperimental'naia i klinicheskaia farmakologiia · 2012
Not a test of Bromantane alone · 6 results
[Thermoprotector properties of a combination of sydnocarb with ladasten].
Levina MN · Eksperimental'naia i klinicheskaia farmakologiia · 2006
Not a test of Bromantane alone · 4 results

Status and safety

Regulatory and safety

Approval and sport status, and the safety outcomes reported in study results. Laws and labels change, so check the regulator for the current status.

Regulatory status by jurisdiction, with date and source
Jurisdiction	Body	Status	As of	Source
US	FDA	The openFDA active ingredient search returned no matches. This confirms no matching entry in this database, not worldwide absence of approval.	22 Oct 2026	api.fda.gov (opens in a new tab)
EU	EMA	No authorised exact product match was found in the EMA central medicine catalogue. National authorisations are outside this check.	22 Oct 2026	ema.europa.eu (opens in a new tab)
Sport	WADA	Banned in sport (WADA S6.A) Bromantan is a named non-specified stimulant.	2026 List	wada-ama.org (opens in a new tab)
Russia	National register	Approved in Russia Registered medicine Ladasten (Ладастен), prescription only: registration ЛП-№(005486)-(РГ-RU) of 2024-05-16; earlier ЛСР-010257/08 of 2008-12-19. Read from Vidal and a copy of the State Register of Medicines (zdravmedinform.ru, accessed 2026-10-22); the official register search returned a CAPTCHA.	22 Oct 2026	vidal.ru (opens in a new tab)

Safety outcomes

97 safety results for Bromantane.

Human evidence· 6

In patients with neurasthenia, no withdrawal syndrome occurred after ladasten withdrawal.
Randomized controlled trialn not reported
In patients with psychoautonomic syndrome, adverse effects occurred in 3% during ladasten therapy.
Non-randomized trialn = 728
Adverse effects
3%
ladasten-treated patients
In patients with psychoautonomic syndrome, ladasten therapy was discontinued in 0.8%.
Non-randomized trialn = 728
Discontinuation
0.8%
ladasten-treated patients
In patients with psychoautonomic syndrome, no serious adverse effects occurred during ladasten therapy.
Non-randomized trialn = 728
In patients with neurasthenia, self-rated tolerability of ladasten was high and comparable with placebo.
Non-randomized trialn not reported
In healthy volunteers, single-dose ladasten did not exhibit behavioral toxicity.
Non-randomized trialn not reported

Animal evidence· 91

In rat dams, general state did not differ significantly across groups during or after bromantan treatment.
Animal study (in vivo)rat
In rat dams, activity did not differ significantly across groups during or after bromantan treatment.
Animal study (in vivo)rat
In rat dams, bromantan had no adverse effect on body weight.
Animal study (in vivo)rat
In rat dams, bromantan had no adverse effect on gestation length.
Animal study (in vivo)rat
In rats, the number of bromantan-exposed dams delivering did not differ from controls.
Animal study (in vivo)rat
Stillborn rat pups occurred in all litters, with fewer in controls than in bromantan groups.
Animal study (in vivo)rat
One dam in the first bromantan group delivered a rat pup with a head hematoma.
Animal study (in vivo)rat
In rats, maternal bromantan at the low dose reduced litter size compared with controls.
Animal study (in vivo)rat
Litter size decrease
34.9%
30-mg/kg group

The top 18 of 91 results.

Doses studied · 59

The doses that these studies used. They are not recommendations.

50 to 100 mg dailyHuman
Species
human
Route
Not reported
Duration
28 days
Design
Non-randomized trial · n = 728
0.25 gHuman
Species
human
Route
Not reported
Duration
Not reported
Design
Non-randomized trial
15 mgHuman
Species
human
Route
Not reported
Duration
single dose
Design
Non-randomized trial
100 mgHuman
Species
human
Route
Not reported
Duration
single dose
Design
Non-randomized trial
30, 150 and 600 mg/kg dailyAnimal
Species
rat
Route
oral
Duration
16 days
Design
Animal study (in vivo)
30 mg/kgAnimal
Species
rat
Route
oral
Duration
16 days
Design
Animal study (in vivo)

Doses studied in the study results, as given in the studies.
Dose as reported	Class	Species	Route	Duration	Design
50 to 100 mg daily	Human	human	Not reported	28 days	Non-randomized trial · n = 728
0.25 g	Human	human	Not reported	Not reported	Non-randomized trial
15 mg	Human	human	Not reported	single dose	Non-randomized trial
100 mg	Human	human	Not reported	single dose	Non-randomized trial
30, 150 and 600 mg/kg daily	Animal	rat	oral	16 days	Animal study (in vivo)
30 mg/kg	Animal	rat	oral	16 days	Animal study (in vivo)

6 of 59 shown

PepBank is a research reference. Talk to a doctor before you use any peptide.

Data

Data and API

Data version, change history and code for this peptide.

Data version 30856030 Oct 2026

Peptide

Peptide id: PEP-000081
Peptide version: 4
Peptide hash: a07459cd6e612c99…
Data version: 308560

Latest changes

27 Oct 2026UpdatedData version 256647
22 Oct 2026UpdatedData version 254494
21 Oct 2026UpdatedData version 226598
21 Oct 2026CreatedData version 213597

For developers

curl -s https://pepbank.io/v1/briefs/bromantane

Evidence summary for Bromantane: counts by class, key results with sources, notices, data version.

Peptide as JSON Evidence summary as JSON

Outcome group	Human	Animal	Lab	Computer model	Total
Receptor activity and mechanismNervous system and cognition	Human: 9 results from 2 studies: 4 increase, 4 decrease, 1 not reported. Strongest design: Non-randomized trial	Animal: 49 results from 15 studies: 18 increase, 14 decrease, 5 no significant change, 12 not reported. Strongest design: Animal study (in vivo)	Lab: 12 results from 3 studies: 2 increase, 4 decrease, 6 no significant change. Strongest design: Ex vivo tissue	No results	70
Adverse eventsWhole body	Human: 6 results from 4 studies: 1 no significant change, 5 not reported. Strongest design: Randomized controlled trial	Animal: 21 results from 3 studies: 2 increase, 2 no significant change, 7 mixed, 10 not reported. Strongest design: Animal study (in vivo)	No results	No results	27
Anxiety and moodNervous system and cognition	Human: 6 results from 4 studies: 3 increase, 2 decrease, 1 no significant change. Strongest design: Non-randomized trial	Animal: 13 results from 8 studies: 2 increase, 8 decrease, 1 no significant change, 2 not reported. Strongest design: Animal study (in vivo)	No results	No results	19
Exercise and physical functionWhole body	Human: 4 results from 2 studies: 2 increase, 1 decrease, 1 no significant change. Strongest design: Non-randomized trial	Animal: 23 results from 7 studies: 13 increase, 8 decrease, 1 mixed, 1 not reported. Strongest design: Animal study (in vivo)	No results	No results	27
Overall treatment effectNervous system and cognition	Human: 3 results from 2 studies: 1 increase, 2 not reported. Strongest design: Non-randomized trial	No results	No results	No results	3
FatigueWhole body	Human: 2 results from 2 studies: 2 decrease. Strongest design: Randomized controlled trial	No results	No results	No results	2
Patient-reported outcomesMental health and mood	Human: 2 results from 1 study: 1 no significant change, 1 not reported. Strongest design: Non-randomized trial	No results	No results	No results	2
Cognition and memoryNervous system and cognition	Human: 1 result from 1 study: 1 not reported. Strongest design: Non-randomized trial	Animal: 1 result from 1 study: 1 increase. Strongest design: Animal study (in vivo)	No results	No results	2
Autonomic functionNervous system and cognition	Human: 1 result from 1 study: 1 decrease. Strongest design: Non-randomized trial	No results	No results	No results	1
Quality of lifeWhole body	Human: 1 result from 1 study: 1 increase. Strongest design: Non-randomized trial	No results	No results	No results	1
SleepSleep	Human: 1 result from 1 study: 1 decrease. Strongest design: Non-randomized trial	No results	No results	No results	1
Locomotor and behavioral activityNervous system and cognition	No results	Animal: 22 results from 3 studies: 10 increase, 7 decrease, 5 no significant change. Strongest design: Animal study (in vivo)	No results	No results	22

Outcome group	Human	Animal	Lab	Computer model	Total
Receptor activity and mechanismNervous system and cognition	Human: 9 results from 2 studies: 4 increase, 4 decrease, 1 not reported. Strongest design: Non-randomized trial	Animal: 49 results from 15 studies: 18 increase, 14 decrease, 5 no significant change, 12 not reported. Strongest design: Animal study (in vivo)	Lab: 12 results from 3 studies: 2 increase, 4 decrease, 6 no significant change. Strongest design: Ex vivo tissue	No results	70
Adverse eventsWhole body	Human: 6 results from 4 studies: 1 no significant change, 5 not reported. Strongest design: Randomized controlled trial	Animal: 21 results from 3 studies: 2 increase, 2 no significant change, 7 mixed, 10 not reported. Strongest design: Animal study (in vivo)	No results	No results	27
Anxiety and moodNervous system and cognition	Human: 6 results from 4 studies: 3 increase, 2 decrease, 1 no significant change. Strongest design: Non-randomized trial	Animal: 13 results from 8 studies: 2 increase, 8 decrease, 1 no significant change, 2 not reported. Strongest design: Animal study (in vivo)	No results	No results	19
Exercise and physical functionWhole body	Human: 4 results from 2 studies: 2 increase, 1 decrease, 1 no significant change. Strongest design: Non-randomized trial	Animal: 23 results from 7 studies: 13 increase, 8 decrease, 1 mixed, 1 not reported. Strongest design: Animal study (in vivo)	No results	No results	27
Overall treatment effectNervous system and cognition	Human: 3 results from 2 studies: 1 increase, 2 not reported. Strongest design: Non-randomized trial	No results	No results	No results	3
FatigueWhole body	Human: 2 results from 2 studies: 2 decrease. Strongest design: Randomized controlled trial	No results	No results	No results	2
Patient-reported outcomesMental health and mood	Human: 2 results from 1 study: 1 no significant change, 1 not reported. Strongest design: Non-randomized trial	No results	No results	No results	2
Cognition and memoryNervous system and cognition	Human: 1 result from 1 study: 1 not reported. Strongest design: Non-randomized trial	Animal: 1 result from 1 study: 1 increase. Strongest design: Animal study (in vivo)	No results	No results	2
Autonomic functionNervous system and cognition	Human: 1 result from 1 study: 1 decrease. Strongest design: Non-randomized trial	No results	No results	No results	1
Quality of lifeWhole body	Human: 1 result from 1 study: 1 increase. Strongest design: Non-randomized trial	No results	No results	No results	1
SleepSleep	Human: 1 result from 1 study: 1 decrease. Strongest design: Non-randomized trial	No results	No results	No results	1
Locomotor and behavioral activityNervous system and cognition	No results	Animal: 22 results from 3 studies: 10 increase, 7 decrease, 5 no significant change. Strongest design: Animal study (in vivo)	No results	No results	22

Bromantane studies and research data

Bromantane identity

Targets

Structure

2D structure

Bromantane results by year and outcome

What the studies measured

Bromantane studies on receptors and cell signals

Bromantane studies on daily life and fitness

Bromantane studies on side effects

Bromantane studies on mood, stress and behavior

Bromantane studies on overall treatment results

Bromantane studies on brain and nerves

Bromantane studies on memory and thinking

Bromantane studies on sleep

Bromantane studies on sex hormones and fertility

Bromantane studies on cells, genes and aging

Bromantane studies on weight and appetite

Bromantane studies on heart and blood vessels

Bromantane studies on immune system and inflammation

Bromantane studies on autism and child development

Bromantane studies on sexual and women's health

Bromantane studies on lungs and breathing

Bromantane studies on cancer

Bromantane studies on metabolism and nutrition

Bromantane studies on survival and serious illness

Bromantane trials

Papers

Studies with results

Effects of bromantan on offspring maturation and development of reflexes.

The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats.

[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].

Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.

[Effect of the long term administration of bromantan on the reproductive function in rats].

[The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain].

Correcting effect of ladasten on variations in the subpopulation composition of T lymphocytes in C57BL/6 mice on the experimental model of an anxious-depressive state.

[Characteristics of ladasten effect in neurasthenia patients with various EEG parameters].

[Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015].

[Analysis of the binding capacity of the benzodiazepine site of gabaa receptor in mice C57BL/6 and BALB/C pretreated with anxiolytics].

[Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types].

[Experimental rationale for the use of drugs to increase the resistance of the human body to the combined action of carbon monoxide and hyperthermia].

[A quantitative pharmaco-electroencephalographic analysis of the action of bromantane].

[The mechanisms of the neurotropic action of bromantan].

[The effect of bromantane on the behavior of inbred mouse strains with different phenotypes of emotional stress reaction].

[The effect of bromantane on the cardiovascular and sympathetic-adrenal systems in animals].

[An acute toxicity study of bromantane].

More studies

Plant Adaptogens-History and Future Perspectives.

The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.

Ruthenium-catalyzed reductive amination without an external hydrogen source.

[The effect of bromantane, a new immunostimulant with psychostimulating action, on release and metabolism of dopamine in the dorsal striatum of freely moving rats: a microdialysis study].

[Adamantane derivatives enhancing body's resistance to emergencies].

[Comparative analysis of effects of adapromine, midantan, and bromantane on the bioelectric activity of the rat brain].

[Analysis of pharmacological properties of bromantane].

[STUDYING SOME PHARMACOLOGICAL EFFECTS OF NEW 3-HYDROXYPYRIDINE DERIVATIVE].

Newer studies

Bromantane studies: 51 papers with results

Regulatory and safety

Human evidence· 6

Animal evidence· 91

Doses studied · 59

Data and API

Peptide

Latest changes

For developers

Related peptides

Bromantane results by year and outcome

Bromantane studies on receptors and cell signals

Bromantane studies on daily life and fitness

Bromantane studies on side effects

Bromantane studies on mood, stress and behavior

Bromantane studies on overall treatment results

Bromantane studies on brain and nerves

Bromantane studies on memory and thinking

Bromantane studies on sleep

Bromantane studies on sex hormones and fertility

Bromantane studies on cells, genes and aging

Bromantane studies on weight and appetite

Bromantane studies on heart and blood vessels

Bromantane studies on immune system and inflammation