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Study · Animal study (in vivo) · mouse and rat · 1998

6 results

[The effect of bromantane on the physical work capacity of laboratory animals].

Morozov IS, Kleĭmenova NN

Eksperimental'naia i klinicheskaia farmakologiia1 Nov 1998

PMID9929819 (opens in a new tab)PepBankPUB-09929819
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice and rats, bromantan improved physical work efficiency more than optimally dosed phenamine.

    In plain wordsIn mice and rats, bromantan improved physical work efficiency more than phenamine at optimal doses.

    Peptide
    Bromantane
    Outcome
    IncreasePhysical work efficiency
    Study

    mice and ratsn: not reported in source

    Comparator
    Phenamine at optimal doses
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.5-50 mg/kgAs given in this study (mice and rats).

    Measurements

    Relative effect
    1.3 to 1.6 times
    versus phenamine

    Source sentences

    Summary
    The positive effect of bromantan (0.5-50 mg/kg) on the efficiency of physical work of mice and rats (swimming test, running on a treadmill) exceeds that of phenamine administered in optimal doses by 1.3-1.6 times.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice and rats, bromantan's physical efficiency effect lasted at least 24 h.

    In plain wordsIn mice and rats, bromantan's physical efficiency effect lasted at least 24 h.

    Peptide
    Bromantane
    Outcome
    Not applicableDuration of physical efficiency effect
    Study

    mice and ratsn: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.5-50 mg/kgAs given in this study (mice and rats).

    Measurements

    Effect duration
    ≥ 24 h
    physical efficiency

    Source sentences

    Summary
    Such an effect of bromantan lasts no less than 24 h.
    1 context sentence
    Summary · context
    The positive effect of bromantan (0.5-50 mg/kg) on the efficiency of physical work of mice and rats (swimming test, running on a treadmill) exceeds that of phenamine administered in optimal doses by 1.3-1.6 times.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In laboratory animals, bromantan delayed physical efficiency decline during repeated extreme running loads.

    In plain wordsIn animals, bromantan delayed the decline in physical efficiency during repeated extreme running.

    Peptide
    Bromantane
    Outcome
    DecreasePhysical efficiency decline during repeated loads
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.5-50 mg/kgAs given in this study.

    Source sentences

    Summary
    The drug delays decrease of physical efficiency and restores it sooner in repeated extreme running loads, prevents in rats the corresponding electron-microscopic changes in the cardiomyocyte and myocyte mitochondria of the skeletal muscles.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In laboratory animals, bromantan restored physical efficiency sooner during repeated extreme running loads.

    In plain wordsIn animals, bromantan restored physical efficiency sooner during repeated extreme running.

    Peptide
    Bromantane
    Outcome
    IncreasePhysical efficiency recovery
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.5-50 mg/kgAs given in this study.

    Source sentences

    Summary
    The drug delays decrease of physical efficiency and restores it sooner in repeated extreme running loads, prevents in rats the corresponding electron-microscopic changes in the cardiomyocyte and myocyte mitochondria of the skeletal muscles.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan prevented cardiomyocyte mitochondrial changes associated with extreme running loads.

    In plain wordsIn rats, bromantan prevented heart-cell mitochondrial changes associated with extreme running.

    Peptide
    Bromantane
    Outcome
    DecreaseCardiomyocyte mitochondrial changes
    Study

    ratn: not reported in source

    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.5-50 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    The drug delays decrease of physical efficiency and restores it sooner in repeated extreme running loads, prevents in rats the corresponding electron-microscopic changes in the cardiomyocyte and myocyte mitochondria of the skeletal muscles.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan prevented skeletal myocyte mitochondrial changes associated with extreme running loads.

    In plain wordsIn rats, bromantan prevented skeletal muscle mitochondrial changes associated with extreme running.

    Peptide
    Bromantane
    Outcome
    DecreaseSkeletal muscle mitochondrial changes
    Study

    ratn: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    0.5-50 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    The drug delays decrease of physical efficiency and restores it sooner in repeated extreme running loads, prevents in rats the corresponding electron-microscopic changes in the cardiomyocyte and myocyte mitochondria of the skeletal muscles.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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