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Study · Animal study (in vivo) · rat · 1995

7 results

[The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain].

Kudrin VS, Sergeeva SA, Krasnykh LM, Miroshnichenko II, Grekhova TV, Gaĭnetdinov RR

Eksperimental'naia i klinicheskaia farmakologiia1 Jul 1995Cited by 3 (Europe PMC)

PMID7580761 (opens in a new tab)PepBankPUB-07580761
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan significantly increased frontal cortex serotonin content.

    In plain wordsIn rats, bromantan increased serotonin content in the frontal cortex.

    Peptide
    Bromantane
    Outcome
    IncreaseFrontal cortex serotonin
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Bromantan induced a significant increase in the 5-HT and 5-HIAA content in the frontal cortex and delayed an increase in their content in subcortical brain regions.
    1 context sentence
    Summary · context
    The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan significantly increased frontal cortex 5-HIAA content.

    In plain wordsIn rats, bromantan increased 5-HIAA content in the frontal cortex.

    Peptide
    Bromantane
    Outcome
    IncreaseFrontal cortex 5-HIAA
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Bromantan induced a significant increase in the 5-HT and 5-HIAA content in the frontal cortex and delayed an increase in their content in subcortical brain regions.
    1 context sentence
    Summary · context
    The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan delayed the increase in subcortical serotonin content.

    In plain wordsIn rats, bromantan delayed the increase in serotonin content in subcortical brain regions.

    Peptide
    Bromantane
    Outcome
    DecreaseSubcortical serotonin increase
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Bromantan induced a significant increase in the 5-HT and 5-HIAA content in the frontal cortex and delayed an increase in their content in subcortical brain regions.
    1 context sentence
    Summary · context
    The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan delayed the increase in subcortical 5-HIAA content.

    In plain wordsIn rats, bromantan delayed the increase in 5-HIAA content in subcortical brain regions.

    Peptide
    Bromantane
    Outcome
    DecreaseSubcortical 5-HIAA increase
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Bromantan induced a significant increase in the 5-HT and 5-HIAA content in the frontal cortex and delayed an increase in their content in subcortical brain regions.
    1 context sentence
    Summary · context
    The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan produced a stable decrease in cerebellar serotonin levels.

    In plain wordsIn rats, bromantan lowered serotonin levels in the cerebellum.

    Peptide
    Bromantane
    Outcome
    DecreaseCerebellar serotonin
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    A stable decrease in the 5-HT and 5-HIAA levels in the cerebellum is observed.
    1 context sentence
    Summary · context
    The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan produced a stable decrease in cerebellar 5-HIAA levels.

    In plain wordsIn rats, bromantan lowered 5-HIAA levels in the cerebellum.

    Peptide
    Bromantane
    Outcome
    DecreaseCerebellar 5-HIAA
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    A stable decrease in the 5-HT and 5-HIAA levels in the cerebellum is observed.
    1 context sentence
    Summary · context
    The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, bromantan affected brain dopamine parameters without a specified direction.

    In plain wordsIn rats, bromantan affected brain dopamine measures, but the abstract gives no direction.

    Peptide
    Bromantane
    Outcome
    Direction not reportedBrain dopamine parameters
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    The drug also affected the DA parameters of the brain thus suggesting an important role of dopaminergic system in the mechanism of pharmacological effects of the drug.
    1 context sentence
    Summary · context
    The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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