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Study · Animal study (in vivo) · mouse · 2011

3 results

Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.

Tallerova AV, Kovalenko LP, Durnev AD, Durnev AD, Seredenin SB

Bulletin of experimental biology and medicine1 Nov 2011Cited by 5 (Europe PMC)

PMID22803040 (opens in a new tab)DOI10.1007/s10517-011-1453-2 (opens in a new tab)PepBankPUB-22803040
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, ladasten decreased TNF-α more potently than imipramine.

    In plain wordsIn mice given LPS, ladasten reduced TNF-α more strongly than imipramine.

    Peptide
    Bromantane
    Outcome
    DecreasePlasma TNF-α
    Study

    mousen: not reported in source

    Male C57Bl/6 mice with LPS-induced depression-like state
    Comparator
    Imipramine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    30 and 50 mg/kg · 5 injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten was more potent than imipramine in decreasing the content of proinflammatory cytokines TNF-α and IL-6 and preventing the development of behavioral disturbances in mice.
    2 context sentences
    Summary · context
    behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in a dose of 100 μg/kg.
    Summary · context
    Ladasten was injected 5 times in doses of 30 and 50 mg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, ladasten decreased IL-6 more potently than imipramine.

    In plain wordsIn mice given LPS, ladasten reduced IL-6 more strongly than imipramine.

    Peptide
    Bromantane
    Outcome
    DecreasePlasma IL-6
    Study

    mousen: not reported in source

    Male C57Bl/6 mice with LPS-induced depression-like state
    Comparator
    Imipramine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    30 and 50 mg/kg · 5 injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten was more potent than imipramine in decreasing the content of proinflammatory cytokines TNF-α and IL-6 and preventing the development of behavioral disturbances in mice.
    2 context sentences
    Summary · context
    behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in a dose of 100 μg/kg.
    Summary · context
    Ladasten was injected 5 times in doses of 30 and 50 mg/kg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, ladasten prevented behavioral disturbances more potently than imipramine.

    In plain wordsIn mice given LPS, ladasten prevented behavioral disturbances more strongly than imipramine.

    Peptide
    Bromantane
    Outcome
    DecreaseBehavioral disturbances
    Study

    mousen: not reported in source

    Male C57Bl/6 mice with LPS-induced depression-like state
    Comparator
    Imipramine
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    30 and 50 mg/kg · 5 injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten was more potent than imipramine in decreasing the content of proinflammatory cytokines TNF-α and IL-6 and preventing the development of behavioral disturbances in mice.
    2 context sentences
    Summary · context
    behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in a dose of 100 μg/kg.
    Summary · context
    Ladasten was injected 5 times in doses of 30 and 50 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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