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Study · Animal study (in vivo) · rat · 2010

5 results

[Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015].

Davydova AI, Klodt PM, Kudrin VS, Kuznetsova EA, Narkevich VB

Eksperimental'naia i klinicheskaia farmakologiia1 Mar 2010Cited by 2 (Europe PMC)

PMID20408420 (opens in a new tab)PepBankPUB-20408420
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Wistar rats with monoamine synthesis blockade, ladasten increased L-DOPA in virtually all studied brain structures except the hippocampus.

    In plain wordsIn rats with blocked monoamine synthesis, ladasten increased L-DOPA in most studied brain regions, except the hippocampus.

    Peptide
    Bromantane
    Outcome
    IncreaseBrain L-DOPA content
    Study

    ratn: not reported in source

    Wistar rats with NSD-1015-induced monoamine synthesis blockade
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to afobazole, ladasten demonstrated the ability to increase the level of L-DOPA (a dopamine precursor) in virtually all functional structures of the brain (except for hippocamp)
    1 context sentence
    Summary · context
    on the model of monoamine synthesis blockade induced by NSD-1015 (aromatic L-amino acid decarboxylase) in the brain structures of Wistar rats are reported.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Wistar rats with monoamine synthesis blockade, ladasten increased HVA content in the nucleus accumbens.

    In plain wordsIn rats with blocked monoamine synthesis, ladasten increased HVA in the nucleus accumbens.

    Peptide
    Bromantane
    Outcome
    IncreaseNucleus accumbens HVA content
    Study

    ratn: not reported in source

    Wistar rats with NSD-1015-induced monoamine synthesis blockade
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ladasten exhibited selectivity with respect to the dopaminergic system and affected only parameters of the dopamine metabolism, in particular, by increasing the HVA content in nucleus accumbens and decreasing it in the hypothalamus.
    1 context sentence
    Summary · context
    on the model of monoamine synthesis blockade induced by NSD-1015 (aromatic L-amino acid decarboxylase) in the brain structures of Wistar rats are reported.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Wistar rats with monoamine synthesis blockade, ladasten decreased hypothalamic HVA content.

    In plain wordsIn rats with blocked monoamine synthesis, ladasten decreased HVA in the hypothalamus.

    Peptide
    Bromantane
    Outcome
    DecreaseHypothalamic HVA content
    Study

    ratn: not reported in source

    Wistar rats with NSD-1015-induced monoamine synthesis blockade
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ladasten exhibited selectivity with respect to the dopaminergic system and affected only parameters of the dopamine metabolism, in particular, by increasing the HVA content in nucleus accumbens and decreasing it in the hypothalamus.
    1 context sentence
    Summary · context
    on the model of monoamine synthesis blockade induced by NSD-1015 (aromatic L-amino acid decarboxylase) in the brain structures of Wistar rats are reported.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In Wistar rats with monoamine synthesis blockade, ladasten increased the HVA/dopamine ratio in the nucleus accumbens.

    In plain wordsIn rats with blocked monoamine synthesis, ladasten increased the HVA/dopamine ratio in the nucleus accumbens.

    Peptide
    Bromantane
    Outcome
    IncreaseNucleus accumbens HVA/dopamine ratio
    Study

    ratn: not reported in source

    Wistar rats with NSD-1015-induced monoamine synthesis blockade
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The drug also affected the dopamine turnover parameters, producing an increase in both HVA/dopamine ratio in nucleus accumbens and DOPAC/dopamine ratio in hippocamp.
    1 context sentence
    Summary · context
    on the model of monoamine synthesis blockade induced by NSD-1015 (aromatic L-amino acid decarboxylase) in the brain structures of Wistar rats are reported.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In Wistar rats with monoamine synthesis blockade, ladasten increased the hippocampal DOPAC/dopamine ratio.

    In plain wordsIn rats with blocked monoamine synthesis, ladasten increased the DOPAC/dopamine ratio in the hippocampus.

    Peptide
    Bromantane
    Outcome
    IncreaseHippocampal DOPAC/dopamine ratio
    Study

    ratn: not reported in source

    Wistar rats with NSD-1015-induced monoamine synthesis blockade
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The drug also affected the dopamine turnover parameters, producing an increase in both HVA/dopamine ratio in nucleus accumbens and DOPAC/dopamine ratio in hippocamp.
    1 context sentence
    Summary · context
    on the model of monoamine synthesis blockade induced by NSD-1015 (aromatic L-amino acid decarboxylase) in the brain structures of Wistar rats are reported.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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