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Study · Ex vivo tissue · rat · 2007

4 results

The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats.

Mikhaylova M, Vakhitova JV, Yamidanov RS, Salimgareeva MKh, Seredenin SB, Behnisch T

Neuropharmacology17 Jul 2007Cited by 6 (Europe PMC)

PMID17854844 (opens in a new tab)DOI10.1016/j.neuropharm.2007.07.001 (opens in a new tab)PepBankPUB-17854844
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hippocampal preparations in vitro, ladasten transformed short-term synaptic potentiation into a long-lasting form.

    In plain wordsIn lab tests with rat hippocampal tissue, ladasten made short-term synaptic strengthening last longer.

    Peptide
    Bromantane
    Outcome
    IncreaseLong-lasting synaptic potentiation
    Study

    ratn: not reported in source

    Rat hippocampal preparations
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microMAs given in this study (rat).

    Source sentences

    Summary
    We then investigated the effects of ladasten on activity-dependent hippocampal synaptic plasticity in vitro and found that application of 10 microM ladasten transforms short-term potentiation of synaptic transmission to a long-lasting form.
  2. 02LabEx vivo tissueMechanism

    In rat hippocampal preparations, ladasten transformed short-term into long-term potentiation when applied after tetanization.

    In plain wordsIn lab tests with rat hippocampal tissue, ladasten prolonged synaptic strengthening when applied after stimulation.

    Peptide
    Bromantane
    Outcome
    IncreaseDelayed reinforcement of synaptic potentiation
    Study

    ratn: not reported in source

    Rat hippocampal preparations
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A transformation of short-term into long-term potentiation was also observed, when ladasten was applied 40 min after a single 100 Hz 200 ms tetanization.
    1 context sentence
    Summary · context
    We then investigated the effects of ladasten on activity-dependent hippocampal synaptic plasticity in vitro and found that application of 10 microM ladasten transforms short-term potentiation of synaptic transmission to a long-lasting form.

Studies that did not test the peptide alone2

In this study, Bromantane was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Bromantane.

  1. 03LabNot a test of Bromantane aloneEx vivo tissueMechanism

    In rat hippocampal preparations, anisomycin blocked ladasten-associated reinforcement of synaptic potentiation.

    In plain wordsIn lab tests with rat hippocampal tissue, anisomycin blocked ladasten-associated synaptic strengthening.

    Peptide
    Bromantane
    Outcome
    DecreaseProtein synthesis dependence of reinforcement
    Study

    ratn: not reported in source

    Rat hippocampal preparations
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This reinforcement was blocked by the protein synthesis inhibitor anisomycin and could be attenuated by the D1/D5 receptor antagonist SCH23390.
    1 context sentence
    Summary · context
    We then investigated the effects of ladasten on activity-dependent hippocampal synaptic plasticity in vitro and found that application of 10 microM ladasten transforms short-term potentiation of synaptic transmission to a long-lasting form.

    In this study, Bromantane was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bromantane.

  2. 04LabNot a test of Bromantane aloneEx vivo tissueMechanism

    In rat hippocampal preparations, SCH23390 could attenuate ladasten-associated reinforcement of synaptic potentiation.

    In plain wordsIn lab tests with rat hippocampal tissue, SCH23390 could reduce ladasten-associated synaptic strengthening.

    Peptide
    Bromantane
    Outcome
    DecreaseD1/D5 receptor dependence of reinforcement
    Study

    ratn: not reported in source

    Rat hippocampal preparations
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This reinforcement was blocked by the protein synthesis inhibitor anisomycin and could be attenuated by the D1/D5 receptor antagonist SCH23390.
    1 context sentence
    Summary · context
    We then investigated the effects of ladasten on activity-dependent hippocampal synaptic plasticity in vitro and found that application of 10 microM ladasten transforms short-term potentiation of synaptic transmission to a long-lasting form.

    In this study, Bromantane was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bromantane.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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