Skip to content

Study · Animal study (in vivo) · rat · 2005

3 results

[Studying the mechanisms of ladasten action].

Iarkova MA, Voronin MV, Seredenin SB

Eksperimental'naia i klinicheskaia farmakologiia1 May 2005

PMID16047669 (opens in a new tab)PepBankPUB-16047669
Publisher pageAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In MR rats, ladasten produced an anxiolytic effect in the open-field test.

    In plain wordsIn rats of the MR strain, ladasten reduced anxiety-like behavior.

    Peptide
    Bromantane
    Outcome
    DecreaseAnxiety in MR rats
    Study

    ratn: not reported in source

    MR inbred rats in open-field test
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    30 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Ladasten (30 mg/kg, i.p.) produced anxiolytic effect in MR rates, while not influencing MNRA animals.
    1 context sentence
    Summary · context
    The effect of N-(2-adamantyl)-N-(p-bromophenyl)amine (ladasten) on the behavior of MR and MNRA inbred rats with different emotional-stress reaction (ESR) phenotypes was studied in the conventional open-field test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In MNRA rats, ladasten did not influence behavior in the open-field test.

    In plain wordsIn rats of the MNRA strain, ladasten did not affect behavior in the open-field test.

    Peptide
    Bromantane
    Outcome
    No significant changeAnxiety in MNRA rats
    Study

    ratn: not reported in source

    MNRA inbred rats in open-field test
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    30 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Ladasten (30 mg/kg, i.p.) produced anxiolytic effect in MR rates, while not influencing MNRA animals.
    1 context sentence
    Summary · context
    The effect of N-(2-adamantyl)-N-(p-bromophenyl)amine (ladasten) on the behavior of MR and MNRA inbred rats with different emotional-stress reaction (ESR) phenotypes was studied in the conventional open-field test.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In stressed MR rats, ladasten prevented stress-induced reception changes at the benzodiazepine site of the GABA(A) receptor.

    In plain wordsIn rats, ladasten prevented stress-induced changes at the GABA(A) receptor's benzodiazepine site.

    Peptide
    Bromantane
    Outcome
    DecreaseStress-induced benzodiazepine-site reception changes
    Study

    ratn: not reported in source

    Stressed MR rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    30 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Ladasten administered in the anxiolytic dose prevented stress-induced changes in reception at this site.
    2 context sentences
    Summary · context
    At the same time, a model stress induced disorder in the regulation of 3 H-diazepam binding to the benzodiazepine site of GABA(A) receptor in MR (but not in MNRA) rats.
    Summary · context
    The effect of N-(2-adamantyl)-N-(p-bromophenyl)amine (ladasten) on the behavior of MR and MNRA inbred rats with different emotional-stress reaction (ESR) phenotypes was studied in the conventional open-field test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.