Skip to content

Study · Animal study (in vivo) · rat · 2000

18 results

[Effect of bromantane on the rat neurologic status in two month course].

Iëzhitsa IN, Bugaeva LI, Spasov AA, Morozov IS

Eksperimental'naia i klinicheskaia farmakologiia1 Sept 2000

PMID11109517 (opens in a new tab)PepBankPUB-11109517
Publisher pageAsk about this study
Jump to 18 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study18

18 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, bromantan reduced motor activity at the effective dose.

    In plain wordsIn male rats, bromantan reduced motor activity at the effective dose.

    Peptide
    Bromantane
    Outcome
    DecreaseMale motor activity
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    30 mg/kg · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The oral administration of bromantan for two months on a toxic dose level produced a sex-dependent psychodysleptic action upon rats: the effective (30 mg/kg), intermediate (150 mg/kg), and toxic (600 mg/kg) doses reduced the motor activity in males, while not affecting (or increasing) this activity in females.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, bromantan reduced motor activity at the intermediate dose.

    In plain wordsIn male rats, bromantan reduced motor activity at the intermediate dose.

    Peptide
    Bromantane
    Outcome
    DecreaseMale motor activity
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    150 mg/kg · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The oral administration of bromantan for two months on a toxic dose level produced a sex-dependent psychodysleptic action upon rats: the effective (30 mg/kg), intermediate (150 mg/kg), and toxic (600 mg/kg) doses reduced the motor activity in males, while not affecting (or increasing) this activity in females.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, bromantan reduced motor activity at the toxic dose.

    In plain wordsIn male rats, bromantan reduced motor activity at the toxic dose.

    Peptide
    Bromantane
    Outcome
    DecreaseMale motor activity
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    600 mg/kg · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The oral administration of bromantan for two months on a toxic dose level produced a sex-dependent psychodysleptic action upon rats: the effective (30 mg/kg), intermediate (150 mg/kg), and toxic (600 mg/kg) doses reduced the motor activity in males, while not affecting (or increasing) this activity in females.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, bromantan did not affect or increased motor activity.

    In plain wordsIn female rats, bromantan left motor activity unchanged or increased it.

    Peptide
    Bromantane
    Outcome
    MixedFemale motor activity
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    30, 150, and 600 mg/kg · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The oral administration of bromantan for two months on a toxic dose level produced a sex-dependent psychodysleptic action upon rats: the effective (30 mg/kg), intermediate (150 mg/kg), and toxic (600 mg/kg) doses reduced the motor activity in males, while not affecting (or increasing) this activity in females.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the effective bromantan dose stimulated exploratory activity.

    In plain wordsIn rats, the effective bromantan dose increased exploration.

    Peptide
    Bromantane
    Outcome
    IncreaseExploratory activity
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    effective dose · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The effective dose stimulated, and the toxic dose suppressed, the research activity and increased the number of grooming episodes, while ambiguously influencing the emotional state of rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the toxic bromantan dose suppressed exploratory activity.

    In plain wordsIn rats, the toxic bromantan dose reduced exploration.

    Peptide
    Bromantane
    Outcome
    DecreaseExploratory activity
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    toxic dose · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The effective dose stimulated, and the toxic dose suppressed, the research activity and increased the number of grooming episodes, while ambiguously influencing the emotional state of rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan increased grooming episodes.

    In plain wordsIn rats, bromantan increased grooming episodes.

    Peptide
    Bromantane
    Outcome
    IncreaseGrooming episodes
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The effective dose stimulated, and the toxic dose suppressed, the research activity and increased the number of grooming episodes, while ambiguously influencing the emotional state of rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan ambiguously affected emotional state.

    In plain wordsIn rats, bromantan had unclear effects on emotional state.

    Peptide
    Bromantane
    Outcome
    Direction not reportedEmotional state
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The effective dose stimulated, and the toxic dose suppressed, the research activity and increased the number of grooming episodes, while ambiguously influencing the emotional state of rats.
  9. 09AnimalAnimal study (in vivo)Safety outcome

    In rats, bromantan caused initial hypothermia followed by slight hyperthermia in the second month.

    In plain wordsIn rats, bromantan initially lowered body temperature, then slightly raised it in the second month.

    Peptide
    Bromantane
    Outcome
    MixedBody temperature
    Study

    ratn: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    In the initial stage of treatment, bromantan causes hypothermia; in the second month, this effect is replaced by slight hyperthermia.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats, prolonged large-dose bromantan reduced food intake.

    In plain wordsIn rats, prolonged large-dose bromantan reduced food intake.

    Peptide
    Bromantane
    Outcome
    DecreaseFood intake
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    large dose · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    Prolonged administration of a large dose of bromantan oppressed food uptake and slightly increased drink uptake.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats, prolonged large-dose bromantan slightly increased drinking.

    In plain wordsIn rats, prolonged large-dose bromantan slightly increased drinking.

    Peptide
    Bromantane
    Outcome
    IncreaseWater intake
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    large dose · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    Prolonged administration of a large dose of bromantan oppressed food uptake and slightly increased drink uptake.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, bromantan increased body weight.

    In plain wordsIn female rats, bromantan increased body weight.

    Peptide
    Bromantane
    Outcome
    IncreaseFemale body weight
    Study

    ratn: not reported in source

    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    Upon the bromantan treatment, the body weight increased in females and decreased in males.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, bromantan decreased body weight.

    In plain wordsIn male rats, bromantan decreased body weight.

    Peptide
    Bromantane
    Outcome
    DecreaseMale body weight
    Study

    ratn: not reported in source

    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    Upon the bromantan treatment, the body weight increased in females and decreased in males.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the bromantan course increased muscle strength.

    In plain wordsIn rats, bromantan increased muscle strength.

    Peptide
    Bromantane
    Outcome
    IncreaseMuscle strength
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The bromantan treatment course increased the muscle strength of rats; the operant activity was optimized during the first month of the course.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan optimized operant activity during the first month.

    In plain wordsIn rats, bromantan improved operant activity during the first month.

    Peptide
    Bromantane
    Outcome
    IncreaseOperant activity
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The bromantan treatment course increased the muscle strength of rats; the operant activity was optimized during the first month of the course.
  16. 16AnimalAnimal study (in vivo)Safety outcome

    In rats, physiological and behavioral characteristics recovered within two months after bromantan cessation.

    In plain wordsIn rats, physiological and behavioral measures recovered within two months after bromantan stopped.

    Peptide
    Bromantane
    Outcome
    Not applicablePost-treatment recovery
    Study

    ratn: not reported in source

    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The general physiological and behavioral characteristics of animals restored within two months after termination of the treatment course.
  17. 17AnimalAnimal study (in vivo)Safety outcome

    In rats, no significant behavioral dependence symptoms appeared after bromantan cessation.

    In plain wordsIn rats, no significant behavioral signs of dependence appeared after bromantan stopped.

    Peptide
    Bromantane
    Outcome
    No significant changeDependence symptoms
    Study

    ratn: not reported in source

    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    During this period, the test animals exhibited no significant behavioral symptoms indicative of the drug dependence.
    1 context sentence
    Summary · context
    The general physiological and behavioral characteristics of animals restored within two months after termination of the treatment course.
  18. 18AnimalAnimal study (in vivo)Safety outcome

    In rats, two-month bromantan treatment did not produce tolerance to its physical and operant capacity effects.

    In plain wordsIn rats, bromantan did not produce tolerance to its effects on physical and operant capacity.

    Peptide
    Bromantane
    Outcome
    No significant changeTolerance
    Study

    ratn: not reported in source

    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · oral · two monthsAs given in this study (rat).

    Source sentences

    Summary
    The two-month treatment did not lead to the development of tolerance with respect to the optimizing drug action upon the physical and operant capacity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.