[The effect of bromantane on the cardiovascular and sympathetic-adrenal systems in animals].

Morozov IS, Efimova LP, Kryzhanovskiĭ SA

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2000Cited by 1 (Europe PMC)

PMID10763107PepBankPUB-10763107

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, bromantan markedly increased stroke blood volume.
In plain wordsIn rats under anesthesia, bromantan markedly increased blood volume pumped per heartbeat.
Peptide
Bromantane
Outcome
IncreaseStroke volume
Study
ratn: not reported in source
anaesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase.
Report a problemFND-1076310701
02AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, bromantan markedly increased minute blood volume.
In plain wordsIn rats under anesthesia, bromantan markedly increased blood volume pumped per minute.
Peptide
Bromantane
Outcome
IncreaseMinute blood volume
Study
ratn: not reported in source
anaesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase.
Report a problemFND-1076310702
03AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, bromantan reduced heart rate.
In plain wordsIn rats under anesthesia, bromantan reduced heart rate.
Peptide
Bromantane
Outcome
DecreaseHeart rate
Study
ratn: not reported in source
anaesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase.
Report a problemFND-1076310703
04AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, bromantan reduced peripheral resistance.
In plain wordsIn rats under anesthesia, bromantan reduced peripheral blood vessel resistance.
Peptide
Bromantane
Outcome
DecreasePeripheral resistance
Study
ratn: not reported in source
anaesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase.
Report a problemFND-1076310704
05AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized rats, bromantan produced an insignificant short-term increase in systemic arterial pressure.
In plain wordsIn rats under anesthesia, bromantan produced an insignificant brief increase in arterial blood pressure.
Peptide
Bromantane
Outcome
No significant changeSystemic arterial pressure
Study
ratn: not reported in source
anaesthetized rats
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase.
Report a problemFND-1076310705
06AnimalAnimal study (in vivo)Efficacy outcome
In animals, bromantan weakly increased the pressor effects of adrenaline.
In plain wordsIn animals, bromantan slightly increased the blood pressure response to adrenaline.
Peptide
Bromantane
Outcome
IncreaseAdrenaline pressor response
Study
n: not reported in source
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bromantan also weakly increases the pressor effects of adrenaline and noradrenaline.
Report a problemFND-1076310706
07AnimalAnimal study (in vivo)Efficacy outcome
In animals, bromantan weakly increased the pressor effects of noradrenaline.
In plain wordsIn animals, bromantan slightly increased the blood pressure response to noradrenaline.
Peptide
Bromantane
Outcome
IncreaseNoradrenaline pressor response
Study
n: not reported in source
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bromantan also weakly increases the pressor effects of adrenaline and noradrenaline.
Report a problemFND-1076310707
08AnimalAnimal study (in vivo)Mechanism
In anaesthetized cats, bromantan reduced cervical ganglion induced potential within specified preganglionic stimulation frequency ranges.
In plain wordsIn cats under anesthesia, bromantan reduced induced ganglion electrical potential compared with the initial level at specified stimulation frequencies.
Peptide
Bromantane
Outcome
DecreaseCervical ganglion induced potential
Study
catn: not reported in source
anaesthetized cats; upper cervical ganglion
Comparator
Initial level
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In anaesthetized cats, bromantan modifies the shape of the amplitude-frequency characteristic of EEG measured in the upper cervical ganglion, reducing (against the initial level) the induced potential in the frequency range of the preganglionic fiber stimulation (1-10 and 25-30 Hz).
Report a problemFND-1076310708
09AnimalAnimal study (in vivo)Efficacy outcome
In freely moving rats, bromantan showed a reliable tendency to decrease urinary noradrenaline excretion.
In plain wordsIn rats, bromantan showed a reliable tendency to reduce noradrenaline excretion in urine.
Peptide
Bromantane
Outcome
DecreaseUrinary noradrenaline excretion
Study
ratn: not reported in source
freely moving rats performing learned operant activity
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
In freely moving rats, capable of well-learnt Sidman's [correction of Seedman's] operant activity, bromantan showed a reliable tendency to decrease the rate of noradrenaline and adrenaline excretion with urine.
Report a problemFND-1076310709
10AnimalAnimal study (in vivo)Efficacy outcome
In freely moving rats, bromantan showed a reliable tendency to decrease urinary adrenaline excretion.
In plain wordsIn rats, bromantan showed a reliable tendency to reduce adrenaline excretion in urine.
Peptide
Bromantane
Outcome
DecreaseUrinary adrenaline excretion
Study
ratn: not reported in source
freely moving rats performing learned operant activity
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
In freely moving rats, capable of well-learnt Sidman's [correction of Seedman's] operant activity, bromantan showed a reliable tendency to decrease the rate of noradrenaline and adrenaline excretion with urine.
Report a problemFND-1076310710

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.