Time course of histone deacetylase 1 and acetylated H3 and H4 histones in the brain of rats treated with ladasten.

Salimgareeva MKh, Sadovnikov SV, Yamidanov RS, Vakhitova YV, Seredenin SB

Bulletin of experimental biology and medicine1 Mar 2011

PMID22235395DOI10.1007/s10517-011-1201-7PepBankPUB-22235395

Publisher page PubMedAsk about this study

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, ladasten reduced striatal HDAC1 levels.
In plain wordsIn rats, ladasten reduced HDAC1 levels in the striatum.
Peptide
Bromantane
Outcome
DecreaseStriatal HDAC1 level
Study
ratn: not reported in source
rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 mg/kg · intragastricAs given in this study (rat).
Source sentences
Summary
Ladasten reduced HDAC1 level in rat striatum and hippocampus and modified H3acK9 and H4acK8 levels in various structures of rat brain.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus.
Report a problemFND-2223539501
02AnimalAnimal study (in vivo)Mechanism
In rats, ladasten reduced hippocampal HDAC1 levels.
In plain wordsIn rats, ladasten reduced HDAC1 levels in the hippocampus.
Peptide
Bromantane
Outcome
DecreaseHippocampal HDAC1 level
Study
ratn: not reported in source
rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 mg/kg · intragastricAs given in this study (rat).
Source sentences
Summary
Ladasten reduced HDAC1 level in rat striatum and hippocampus and modified H3acK9 and H4acK8 levels in various structures of rat brain.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus.
Report a problemFND-2223539502
03AnimalAnimal study (in vivo)Mechanism
In rats, ladasten modified H3acK9 levels in various brain structures without a reported direction.
In plain wordsIn rats, ladasten changed acetylated H3 levels in brain regions, with no direction reported.
Peptide
Bromantane
Outcome
Direction not reportedAcetylated H3 Lys9 levels
Study
ratn: not reported in source
rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 mg/kg · intragastricAs given in this study (rat).
Source sentences
Summary
Ladasten reduced HDAC1 level in rat striatum and hippocampus and modified H3acK9 and H4acK8 levels in various structures of rat brain.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus.
Report a problemFND-2223539503
04AnimalAnimal study (in vivo)Mechanism
In rats, ladasten modified H4acK8 levels in various brain structures without a reported direction.
In plain wordsIn rats, ladasten changed acetylated H4 levels in brain regions, with no direction reported.
Peptide
Bromantane
Outcome
Direction not reportedAcetylated H4 Lys8 levels
Study
ratn: not reported in source
rat brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 mg/kg · intragastricAs given in this study (rat).
Source sentences
Summary
Ladasten reduced HDAC1 level in rat striatum and hippocampus and modified H3acK9 and H4acK8 levels in various structures of rat brain.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus.
Report a problemFND-2223539504

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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