In rat hypothalamus, Ladasten increased cytosine demethylation frequency at some transcription-factor binding sites or neighboring motifs compared with control rats.
In plain wordsIn rats, Ladasten increased removal of methyl groups at some tyrosine hydroxylase regulatory sites compared with control rats.
- Peptide
- Bromantane
- Outcome
- IncreaseCytosine demethylation frequency
- Study
ratn: not reported in source
Rat hypothalamus- Comparator
- Control rats
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated · single exposureAs given in this study (rat).
Source sentences
Ladasten was shown to increase frequency of cytosine demethylation in binding sites of some transcription factors or in neighboring motifs.
1 context sentence(design, population, supporting numbers)
In the present study, we employed the bisulfate sequencing technique to detect changes of GpG islands methylation status in the TH gene 5'-flanking region (-650 + 84) in hypothalamus cells of control and experimental rats after a single exposure to Ladasten.