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Study · Animal study (in vivo) · rat · 2010

11 results

[Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb].

Zimin IA, Abaimov DA, Budygin EA, Zolotarev IuA, Kovalev GI

Eksperimental'naia i klinicheskaia farmakologiia1 Feb 2010

PMID20369592 (opens in a new tab)PepBankPUB-20369592
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, a single ladasten dose stimulated striatal dopamine biosynthesis measured ex vivo.

    In plain wordsIn rats, a single ladasten dose increased dopamine production in the striatum, measured after tissue removal.

    Peptide
    Bromantane
    Outcome
    IncreaseStriatal dopamine biosynthesis
    Study

    ratn: not reported in source

    Rat striatum assessed ex vivo after dosing
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · intraperitoneal · single doseAs given in this study (rat).

    Source sentences

    Summary
    Ladasten in a single dose of 50 mg/kg (i.p.) stimulated ex vivo dopamine biosynthesis and release in striatum, without any influence on serotonin formation neither in striatum nor in frontal cortex.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, a single ladasten dose stimulated striatal dopamine release measured ex vivo.

    In plain wordsIn rats, a single ladasten dose increased dopamine release in the striatum, measured after tissue removal.

    Peptide
    Bromantane
    Outcome
    IncreaseStriatal dopamine release
    Study

    ratn: not reported in source

    Rat striatum assessed ex vivo after dosing
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · intraperitoneal · single doseAs given in this study (rat).

    Source sentences

    Summary
    Ladasten in a single dose of 50 mg/kg (i.p.) stimulated ex vivo dopamine biosynthesis and release in striatum, without any influence on serotonin formation neither in striatum nor in frontal cortex.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, a single ladasten dose did not affect striatal serotonin formation measured ex vivo.

    In plain wordsIn rats, a single ladasten dose did not change serotonin production in the striatum.

    Peptide
    Bromantane
    Outcome
    No significant changeStriatal serotonin formation
    Study

    ratn: not reported in source

    Rat striatum assessed ex vivo after dosing
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · intraperitoneal · single doseAs given in this study (rat).

    Source sentences

    Summary
    Ladasten in a single dose of 50 mg/kg (i.p.) stimulated ex vivo dopamine biosynthesis and release in striatum, without any influence on serotonin formation neither in striatum nor in frontal cortex.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, a single ladasten dose did not affect frontal cortical serotonin formation measured ex vivo.

    In plain wordsIn rats, a single ladasten dose did not change serotonin production in the frontal cortex.

    Peptide
    Bromantane
    Outcome
    No significant changeFrontal cortical serotonin formation
    Study

    ratn: not reported in source

    Rat frontal cortex assessed ex vivo after dosing
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50 mg/kg · intraperitoneal · single doseAs given in this study (rat).

    Source sentences

    Summary
    Ladasten in a single dose of 50 mg/kg (i.p.) stimulated ex vivo dopamine biosynthesis and release in striatum, without any influence on serotonin formation neither in striatum nor in frontal cortex.
  5. 05LabEx vivo tissueMechanism

    In rat striatal tissue in vitro, ladasten had no direct effect on dopamine D1 receptors.

    In plain wordsIn lab tests with rat brain tissue, ladasten had no direct effect on D1 receptors.

    Peptide
    Bromantane
    Outcome
    No significant changeD1 receptor effects
    Study

    ratn: not reported in source

    Rat striatum in vitro
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that both drugs do not produce any direct effects on dopamine D1, D2, and D3 receptors in rat striatum as well as on serotonin 5-HT1A and 5-HT2A receptors in rat frontal cortex in vitro.
  6. 06LabEx vivo tissueMechanism

    In rat striatal tissue in vitro, ladasten had no direct effect on dopamine D2 receptors.

    In plain wordsIn lab tests with rat brain tissue, ladasten had no direct effect on D2 receptors.

    Peptide
    Bromantane
    Outcome
    No significant changeD2 receptor effects
    Study

    ratn: not reported in source

    Rat striatum in vitro
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that both drugs do not produce any direct effects on dopamine D1, D2, and D3 receptors in rat striatum as well as on serotonin 5-HT1A and 5-HT2A receptors in rat frontal cortex in vitro.
  7. 07LabEx vivo tissueMechanism

    In rat striatal tissue in vitro, ladasten had no direct effect on dopamine D3 receptors.

    In plain wordsIn lab tests with rat brain tissue, ladasten had no direct effect on D3 receptors.

    Peptide
    Bromantane
    Outcome
    No significant changeD3 receptor effects
    Study

    ratn: not reported in source

    Rat striatum in vitro
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that both drugs do not produce any direct effects on dopamine D1, D2, and D3 receptors in rat striatum as well as on serotonin 5-HT1A and 5-HT2A receptors in rat frontal cortex in vitro.
  8. 08LabEx vivo tissueMechanism

    In rat frontal cortical tissue in vitro, ladasten had no direct effect on serotonin 5-HT1A receptors.

    In plain wordsIn lab tests with rat brain tissue, ladasten had no direct effect on 5-HT1A receptors.

    Peptide
    Bromantane
    Outcome
    No significant change5-HT1A receptor effects
    Study

    ratn: not reported in source

    Rat frontal cortex in vitro
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that both drugs do not produce any direct effects on dopamine D1, D2, and D3 receptors in rat striatum as well as on serotonin 5-HT1A and 5-HT2A receptors in rat frontal cortex in vitro.
  9. 09LabEx vivo tissueMechanism

    In rat frontal cortical tissue in vitro, ladasten had no direct effect on serotonin 5-HT2A receptors.

    In plain wordsIn lab tests with rat brain tissue, ladasten had no direct effect on 5-HT2A receptors.

    Peptide
    Bromantane
    Outcome
    No significant change5-HT2A receptor effects
    Study

    ratn: not reported in source

    Rat frontal cortex in vitro
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is established that both drugs do not produce any direct effects on dopamine D1, D2, and D3 receptors in rat striatum as well as on serotonin 5-HT1A and 5-HT2A receptors in rat frontal cortex in vitro.
  10. 10LabEx vivo tissueMechanism

    In rat striatal synaptosomes, ladasten inhibited active dopamine transport with an IC50 of 3.56 microM.

    In plain wordsIn lab tests with rat nerve endings, ladasten inhibited dopamine transport.

    Peptide
    Bromantane
    Outcome
    DecreaseDopamine active transport
    Study

    ratn: not reported in source

    Rat striatal synaptosomes
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    IC50
    3.56 microM
    ladasten inhibition of dopamine transport

    Source sentences

    Summary
    Both ladasten and sydnocarb inhibited the active transport of dopamine in rat striatal synaptosomes at IC50 = 3.56 microM and 28.66 nM, respectively, but failed to influence the serotonin re-uptake in rat frontal cortex.
  11. 11LabEx vivo tissueMechanism

    In rat frontal cortical tissue, ladasten did not affect serotonin reuptake.

    In plain wordsIn lab tests with rat brain tissue, ladasten did not change serotonin reuptake.

    Peptide
    Bromantane
    Outcome
    No significant changeSerotonin reuptake
    Study

    ratn: not reported in source

    Rat frontal cortex
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both ladasten and sydnocarb inhibited the active transport of dopamine in rat striatal synaptosomes at IC50 = 3.56 microM and 28.66 nM, respectively, but failed to influence the serotonin re-uptake in rat frontal cortex.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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