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Study · Animal study (in vivo) · rat · 2000

5 results

[Effects of bromantane and sidnocarb on long-term operant conditioning and its vegetative correlates in rats].

Morozov IS, Efimova LP, Salenko IuA

Eksperimental'naia i klinicheskaia farmakologiia1 May 2000

PMID10934588 (opens in a new tab)PepBankPUB-10934588
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan augmented the efficacy of prolonged operant activity.

    In plain wordsIn rats, bromantan increased the efficacy of prolonged operant activity.

    Peptide
    Bromantane
    Outcome
    IncreaseOperant activity efficacy
    Study

    ratn: not reported in source

    rats performing prolonged operant activity
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    20 mg/kg · oral · 5 hoursAs given in this study (rat).

    Source sentences

    Summary
    Bromantan (20 mg/kg, p.o.) and sydnocarb (10 mg/kg, p.o.) augment the efficacy of a 5-h operant activity in rats, the effect being achieved through different pathways.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan reduced the number of errors during operant activity.

    In plain wordsIn rats, bromantan reduced errors during operant activity.

    Peptide
    Bromantane
    Outcome
    DecreaseOperant errors
    Study

    ratn: not reported in source

    rats performing prolonged operant activity
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    20 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Bromantan favors the activity optimization by reducing the number of errors at a smaller number of operant reactions.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan optimized operant activity with fewer operant reactions.

    In plain wordsIn rats, bromantan optimized operant activity with fewer reactions.

    Peptide
    Bromantane
    Outcome
    DecreaseOperant reaction count
    Study

    ratn: not reported in source

    rats performing prolonged operant activity
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    20 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Bromantan favors the activity optimization by reducing the number of errors at a smaller number of operant reactions.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan increased the motivational component of electric pain avoidance behavior.

    In plain wordsIn rats, bromantan increased the motivational component of avoiding electric pain.

    Peptide
    Bromantane
    Outcome
    IncreaseMotivational component
    Study

    ratn: not reported in source

    rats performing prolonged operant activity
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    20 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Bromantan increases the tension of motivational component (electric pain irritation avoidance), whereas sydnocarb decreases this component of the operant behavior.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan did not affect the degree of cardiovascular functional activation during operant activity.

    In plain wordsIn rats, bromantan did not affect cardiovascular functional activation during operant activity.

    Peptide
    Bromantane
    Outcome
    No significant changeCardiovascular functional activation
    Study

    ratn: not reported in source

    rats performing prolonged operant activity
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    None of the two drugs affects the degree of functional activation of the cardiovascular system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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