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Study · Animal study (in vivo) · mouse · 2011

5 results

[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].

Tallerova AV, Kovalenko LP, Durnev AD, Seredenin SB

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2011Cited by 6 (Europe PMC)

PMID22288152 (opens in a new tab)PepBankPUB-22288152
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In stressed male mice, ladasten reduced serum IL-6 more than imipramine.

    In plain wordsIn mice with stress-induced depression, ladasten reduced IL-6 more than imipramine.

    Peptide
    Bromantane
    Outcome
    DecreaseSerum IL-6
    Study

    mousen: not reported in source

    C57BL/6 male mice with zoosocial stress-induced anxious depression
    Comparator
    Imipramine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · once or for 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten induced (more significantly than imipramine) a decrease in the level of pro-inflammatory cytokines IL-6, IL-17 and IL-4, removed behavioral changes, and restored indexes of immunity organs.
    2 context sentences
    Summary · context
    Effects of the antiasthenic drug ladasten [N-(2-adamantyl)-N-(para-bromophenyl)amine] on the profile of cytokines, behavior, and indexes of immunity organs was studied on zoosocial stress model in depressed C57BL/6 male mice.
    Summary · context
    Ladasten (30 mg/kg, i.p.) and reference drug imipramine (10 mg/kg, i.p.) were administered either once after 3-day stressor interaction or for 5 days after 10-day interaction.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In stressed male mice, ladasten reduced serum IL-17 more than imipramine.

    In plain wordsIn mice with stress-induced depression, ladasten reduced IL-17 more than imipramine.

    Peptide
    Bromantane
    Outcome
    DecreaseSerum IL-17
    Study

    mousen: not reported in source

    C57BL/6 male mice with zoosocial stress-induced anxious depression
    Comparator
    Imipramine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · once or for 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten induced (more significantly than imipramine) a decrease in the level of pro-inflammatory cytokines IL-6, IL-17 and IL-4, removed behavioral changes, and restored indexes of immunity organs.
    2 context sentences
    Summary · context
    Effects of the antiasthenic drug ladasten [N-(2-adamantyl)-N-(para-bromophenyl)amine] on the profile of cytokines, behavior, and indexes of immunity organs was studied on zoosocial stress model in depressed C57BL/6 male mice.
    Summary · context
    Ladasten (30 mg/kg, i.p.) and reference drug imipramine (10 mg/kg, i.p.) were administered either once after 3-day stressor interaction or for 5 days after 10-day interaction.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In stressed male mice, ladasten reduced serum IL-4 more than imipramine.

    In plain wordsIn mice with stress-induced depression, ladasten reduced IL-4 more than imipramine.

    Peptide
    Bromantane
    Outcome
    DecreaseSerum IL-4
    Study

    mousen: not reported in source

    C57BL/6 male mice with zoosocial stress-induced anxious depression
    Comparator
    Imipramine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · once or for 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten induced (more significantly than imipramine) a decrease in the level of pro-inflammatory cytokines IL-6, IL-17 and IL-4, removed behavioral changes, and restored indexes of immunity organs.
    2 context sentences
    Summary · context
    Effects of the antiasthenic drug ladasten [N-(2-adamantyl)-N-(para-bromophenyl)amine] on the profile of cytokines, behavior, and indexes of immunity organs was studied on zoosocial stress model in depressed C57BL/6 male mice.
    Summary · context
    Ladasten (30 mg/kg, i.p.) and reference drug imipramine (10 mg/kg, i.p.) were administered either once after 3-day stressor interaction or for 5 days after 10-day interaction.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In stressed male mice, ladasten removed behavioral changes more strongly than imipramine.

    In plain wordsIn mice with stress-induced depression, ladasten corrected behavioral changes more strongly than imipramine.

    Peptide
    Bromantane
    Outcome
    DecreaseBehavioral impairments
    Study

    mousen: not reported in source

    C57BL/6 male mice with zoosocial stress-induced anxious depression
    Comparator
    Imipramine
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    30 mg/kg · intraperitoneal · once or for 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten induced (more significantly than imipramine) a decrease in the level of pro-inflammatory cytokines IL-6, IL-17 and IL-4, removed behavioral changes, and restored indexes of immunity organs.
    2 context sentences
    Summary · context
    Effects of the antiasthenic drug ladasten [N-(2-adamantyl)-N-(para-bromophenyl)amine] on the profile of cytokines, behavior, and indexes of immunity organs was studied on zoosocial stress model in depressed C57BL/6 male mice.
    Summary · context
    Ladasten (30 mg/kg, i.p.) and reference drug imipramine (10 mg/kg, i.p.) were administered either once after 3-day stressor interaction or for 5 days after 10-day interaction.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In stressed male mice, ladasten restored reduced indexes of immunity organs more strongly than imipramine.

    In plain wordsIn mice with stress-induced depression, ladasten restored immune-organ indexes more strongly than imipramine.

    Peptide
    Bromantane
    Outcome
    IncreaseIndexes of immunity organs
    Study

    mousen: not reported in source

    C57BL/6 male mice with zoosocial stress-induced anxious depression
    Comparator
    Imipramine
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · once or for 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Ladasten induced (more significantly than imipramine) a decrease in the level of pro-inflammatory cytokines IL-6, IL-17 and IL-4, removed behavioral changes, and restored indexes of immunity organs.
    3 context sentences
    Summary · context
    Different stages of depression were manifested by behavioral impairments, increased concentration of pro-inflammatory cytokines IL-6, IL-17, and IL-4, and decreased indexes of immunity organs.
    Summary · context
    Effects of the antiasthenic drug ladasten [N-(2-adamantyl)-N-(para-bromophenyl)amine] on the profile of cytokines, behavior, and indexes of immunity organs was studied on zoosocial stress model in depressed C57BL/6 male mice.
    Summary · context
    Ladasten (30 mg/kg, i.p.) and reference drug imipramine (10 mg/kg, i.p.) were administered either once after 3-day stressor interaction or for 5 days after 10-day interaction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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