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Study · Animal study (in vivo) · mouse and rat · 1999

7 results

[The characteristics of the neuropsychotropic activity of bromantane in laboratory animals].

Morozov IS, Klimova NV, Karpova TD, Shestopalov SS

Eksperimental'naia i klinicheskaia farmakologiia1 Mar 1999

PMID10340117 (opens in a new tab)PepBankPUB-10340117

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals, bromantan showed psychostimulating activity.

    In plain wordsIn animals, bromantan showed stimulant activity.

    Peptide
    Bromantane
    Outcome
    IncreasePsychostimulant activity
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bromantan [N-2-(para-(bromphenyl)-N-2-(aminoadamantan)] possesses psychostimulating activity in experiments on animals.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In mice, bromantan had an intraperitoneal LD50 of 8100 mg/kg.

    In plain wordsIn mice, the intraperitoneal bromantan dose lethal to half the animals was 8100 mg/kg.

    Peptide
    Bromantane
    Outcome
    Not applicableMedian lethal dose
    Study

    mousen: not reported in source

    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated · intraperitoneal injectionAs given in this study (mouse).

    Measurements

    LD50
    8100 mg/kg
    mice, intraperitoneal injection

    Source sentences

    Summary
    With LD50 8100 mg/kg (mice, intraperitoneal injection) activates simple and complicated forms of behavior, induces EEG effects typical of psychostimulators, is an antagonist of substances with a deprivationg neuropsychotropic effect.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In animals, bromantan activated simple and complicated forms of behavior.

    In plain wordsIn animals, bromantan activated simple and complicated forms of behavior.

    Peptide
    Bromantane
    Outcome
    IncreaseSimple and complicated behavior
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With LD50 8100 mg/kg (mice, intraperitoneal injection) activates simple and complicated forms of behavior, induces EEG effects typical of psychostimulators, is an antagonist of substances with a deprivationg neuropsychotropic effect.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In animals, bromantan induced EEG effects typical of psychostimulants.

    In plain wordsIn animals, bromantan produced brain-wave effects typical of stimulants.

    Peptide
    Bromantane
    Outcome
    Direction not reportedEEG effects
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With LD50 8100 mg/kg (mice, intraperitoneal injection) activates simple and complicated forms of behavior, induces EEG effects typical of psychostimulators, is an antagonist of substances with a deprivationg neuropsychotropic effect.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In animals, bromantan antagonized substances with a depriving neuropsychotropic effect.

    In plain wordsIn animals, bromantan opposed substances with a depressant neuropsychotropic effect.

    Peptide
    Bromantane
    Outcome
    Not applicableAntagonism of depressant substances
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With LD50 8100 mg/kg (mice, intraperitoneal injection) activates simple and complicated forms of behavior, induces EEG effects typical of psychostimulators, is an antagonist of substances with a deprivationg neuropsychotropic effect.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan positively affected mnemonic processes.

    In plain wordsIn rats, bromantan improved memory processes.

    Peptide
    Bromantane
    Outcome
    IncreaseMnemonic processes
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bromantan is characterized by a positive effect on mnemonic processes and on obtaining the results of complex operant activity in rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, bromantan positively affected results of complex operant activity.

    In plain wordsIn rats, bromantan improved results of complex operant activity.

    Peptide
    Bromantane
    Outcome
    IncreaseComplex operant performance
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bromantan is characterized by a positive effect on mnemonic processes and on obtaining the results of complex operant activity in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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