In rat brain cells after ladasten exposure, researchers identified transcription factors with affected DNA-binding activity without specifying the factors or direction.
In plain wordsIn rats, researchers identified brain transcription factors with changed DNA binding after ladasten exposure, but did not specify the changes.
- Peptide
- Bromantane
- Outcome
- Direction not reportedIdentification of transcription factors with altered DNA binding
- Study
ratn: not reported in source
Rat brain cells after ladasten administration- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- 50 mg/kg · single administrationAs given in this study (rat).
Source sentences
Transcriptional factors with affected DNA-binding activity were identified in brain cells.
2 context sentences(design, population, supporting numbers)
Changes in CREB (SER133) content and DNA-binding activity of transcriptional factors in rat brain cells against the background of ladasten exposure.
We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus.