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Study · Animal study (in vivo) · rat · 2005

2 results

[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound].

Vakhitova IuV, Iamidanov RS, Vakhitov VA, Seredenin SB

Molekuliarnaia biologiia1 Mar 2005

PMID15856951 (opens in a new tab)PepBankPUB-15856951
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rat brain, macroarray analysis with RT-PCR corroboration identified changes in expression of 12 genes after Ladasten.

    In plain wordsIn rats, tests identified changes in the activity of 12 brain genes after Ladasten.

    Peptide
    Bromantane
    Outcome
    Direction not reportedAltered gene expression
    Study

    ratn: not reported in source

    Rat brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · acute treatmentAs given in this study (rat).

    Measurements

    Genes with expression changes
    12 genes
    rat brain after ladasten

    Source sentences

    Summary
    The analysis of results of hybridization on macrochips and their corroboration by quantitative real-time RT-PCR has allowed to reveal 12 genes, expression of which changes in response to ladasten in rat brain cells.
    1 context sentence
    Summary · context
    We have used the Rat Atlas cDNA Array ("BD Bioscience") to assess changes in mRNA expression of 588 genes in rat brain after acute treatment of 2-aminoadamantane compound--Ladasten.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rat brain, Ladasten-induced genes included signaling, cytoskeletal, synaptic and metabolic-enzyme genes.

    In plain wordsIn rats, genes activated after Ladasten included genes for cell signaling, cell structure, synaptic proteins and metabolic enzymes.

    Peptide
    Bromantane
    Outcome
    IncreaseFunctional categories of induced genes
    Study

    ratn: not reported in source

    Rat brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · acute treatmentAs given in this study (rat).

    Source sentences

    Summary
    It was shown that Ladasten induced genes are involved in the different signalling pathways (APC, Rb, PKCIP, PMCA), genes encoding the cytosceletal proteins (Tubal, actin), synaptic proteins (Syn IA&IB, PLP) and metabolism enzymes (Gapdh, NSE).
    1 context sentence
    Summary · context
    We have used the Rat Atlas cDNA Array ("BD Bioscience") to assess changes in mRNA expression of 588 genes in rat brain after acute treatment of 2-aminoadamantane compound--Ladasten.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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