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Study · Animal study (in vivo) · rat · 2004

4 results

[Ladasten induces the expression of genes regulating dopamine biosynthesis in various structures of rat brain].

Vakhitova IuV, Iamidanov RS, Seredinin SB

Eksperimental'naia i klinicheskaia farmakologiia1 Jul 2004

PMID15500036 (opens in a new tab)PepBankPUB-15500036
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rat brain, early ladasten effects involved increased dopamine release.

    In plain wordsIn rats, early ladasten effects involved increased dopamine release.

    Peptide
    Bromantane
    Outcome
    IncreaseDopamine release
    Study

    ratn: not reported in source

    rat brain
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    50 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    In the initial stage (first hours) of the drug action, the dopaminergic effects are related to an increase in the dopamine release.
    1 context sentence
    Summary · context
    The effect of ladasten (50 mg/kg) on the activity of tyrosine hydrolase (TH) and DOPA-decarboxylase (DDC) gene expression and on the content of dopamine and L-DOPA in the striatum and hypothalamus in rat brain was studied depending on the duration of drug action.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rat brain, L-DOPA accumulation correlated with transcription activity of the studied genes.

    In plain wordsIn rats, L-DOPA accumulation correlated with activity of genes studied during ladasten exposure.

    Peptide
    Bromantane
    Outcome
    IncreaseL-DOPA accumulation and transcription
    Study

    ratn: not reported in source

    rat brain
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    50 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    The observed accumulation of L-DOPA and dopamine is correlated with the transcription activity of genes studied.
    1 context sentence
    Summary · context
    The effect of ladasten (50 mg/kg) on the activity of tyrosine hydrolase (TH) and DOPA-decarboxylase (DDC) gene expression and on the content of dopamine and L-DOPA in the striatum and hypothalamus in rat brain was studied depending on the duration of drug action.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rat brain, dopamine accumulation correlated with transcription activity of the studied genes.

    In plain wordsIn rats, dopamine accumulation correlated with activity of genes studied during ladasten exposure.

    Peptide
    Bromantane
    Outcome
    IncreaseDopamine accumulation and transcription
    Study

    ratn: not reported in source

    rat brain
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    50 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    The observed accumulation of L-DOPA and dopamine is correlated with the transcription activity of genes studied.
    1 context sentence
    Summary · context
    The effect of ladasten (50 mg/kg) on the activity of tyrosine hydrolase (TH) and DOPA-decarboxylase (DDC) gene expression and on the content of dopamine and L-DOPA in the striatum and hypothalamus in rat brain was studied depending on the duration of drug action.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rat brain, ladasten effects on TH and DDC gene expression differed between hypothalamus and striatum.

    In plain wordsIn rats, ladasten effects on dopamine-related gene expression differed between brain regions.

    Peptide
    Bromantane
    Outcome
    Direction not reportedRegional gene expression response
    Study

    ratn: not reported in source

    rat brain
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    50 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    There is a certain difference in the ladasten action upon the TH and DDC gene expression of the key enzymes in hypothalamus and striatum of rat brain.
    1 context sentence
    Summary · context
    The effect of ladasten (50 mg/kg) on the activity of tyrosine hydrolase (TH) and DOPA-decarboxylase (DDC) gene expression and on the content of dopamine and L-DOPA in the striatum and hypothalamus in rat brain was studied depending on the duration of drug action.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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