[The effect of the actoprotector preparation bromantane on the postnatal development of rat pups].

Iëzhitsa IN, Bugaeva LI, Spasov AA, Morozov IS

Eksperimental'naia i klinicheskaia farmakologiia1 Nov 1999

PMID10650526PepBankPUB-10650526

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study18

18 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Safety outcome
In rats, parental bromantan exposure did not significantly change the number of females giving birth in either mating series.
In plain wordsIn rats, parental bromantan exposure did not significantly change the number of females giving birth compared with controls.
Peptide
Bromantane
Outcome
No significant changeFemales giving birth
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
The number of females who gave birth in series I and II of the experiment, despite a low dose-dependent increase, did not differ significantly from the controls.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052601
02AnimalAnimal study (in vivo)Safety outcome
In rats, paternal bromantan exposure nonsignificantly increased litter size by 0.3% versus controls.
In plain wordsIn rats, paternal bromantan exposure did not significantly increase litter size compared with controls.
Peptide
Bromantane
Outcome
No significant changeLitter size after paternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
30 mg/kg · oral · 60 daysAs given in this study (rat).
Measurements
Litter size increase
0.3%
paternal 30 mg/kg
Source sentences
Summary
In series I of the experiment the litter increased insignificantly depending on the dose (by 0.3, 14.9, and 23.4%, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Bromantan was given per os daily in doses of 30, 150, and 600 mg/kg once a day: females received the drug for 15 days (2.5 estrous cycles), males for 60 days (whole cycle of spermatogenesis).
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052602
03AnimalAnimal study (in vivo)Safety outcome
In rats, paternal bromantan exposure nonsignificantly increased litter size by 14.9% versus controls.
In plain wordsIn rats, paternal bromantan exposure did not significantly increase litter size compared with controls.
Peptide
Bromantane
Outcome
No significant changeLitter size after paternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
150 mg/kg · oral · 60 daysAs given in this study (rat).
Measurements
Litter size increase
14.9%
paternal 150 mg/kg
Source sentences
Summary
In series I of the experiment the litter increased insignificantly depending on the dose (by 0.3, 14.9, and 23.4%, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Bromantan was given per os daily in doses of 30, 150, and 600 mg/kg once a day: females received the drug for 15 days (2.5 estrous cycles), males for 60 days (whole cycle of spermatogenesis).
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052603
04AnimalAnimal study (in vivo)Safety outcome
In rats, paternal bromantan exposure nonsignificantly increased litter size by 23.4% versus controls.
In plain wordsIn rats, paternal bromantan exposure did not significantly increase litter size compared with controls.
Peptide
Bromantane
Outcome
No significant changeLitter size after paternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
600 mg/kg · oral · 60 daysAs given in this study (rat).
Measurements
Litter size increase
23.4%
paternal 600 mg/kg
Source sentences
Summary
In series I of the experiment the litter increased insignificantly depending on the dose (by 0.3, 14.9, and 23.4%, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Bromantan was given per os daily in doses of 30, 150, and 600 mg/kg once a day: females received the drug for 15 days (2.5 estrous cycles), males for 60 days (whole cycle of spermatogenesis).
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052604
05AnimalAnimal study (in vivo)Safety outcome
In rats, maternal bromantan exposure nonsignificantly reduced litter size by 34.9% versus controls.
In plain wordsIn rats, maternal bromantan exposure did not significantly reduce litter size compared with controls.
Peptide
Bromantane
Outcome
No significant changeLitter size after maternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
30 mg/kg · oral · 15 daysAs given in this study (rat).
Measurements
Litter size reduction
34.9%
maternal 30 mg/kg
Source sentences
Summary
In distinction, in the case of experimental females given 30 and 600 mg/kg bromantan before copulation (series II) the number of young rats in the litter insignificantly reduced (by 34.9 and 44.2%), in the case of rats given 150 mg/kg bromantan the litter increased (by 45%, p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052605
06AnimalAnimal study (in vivo)Safety outcome
In rats, maternal bromantan exposure nonsignificantly reduced litter size by 44.2% versus controls.
In plain wordsIn rats, maternal bromantan exposure did not significantly reduce litter size compared with controls.
Peptide
Bromantane
Outcome
No significant changeLitter size after maternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
600 mg/kg · oral · 15 daysAs given in this study (rat).
Measurements
Litter size reduction
44.2%
maternal 600 mg/kg
Source sentences
Summary
In distinction, in the case of experimental females given 30 and 600 mg/kg bromantan before copulation (series II) the number of young rats in the litter insignificantly reduced (by 34.9 and 44.2%), in the case of rats given 150 mg/kg bromantan the litter increased (by 45%, p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052606
07AnimalAnimal study (in vivo)Safety outcome
In rats, maternal bromantan exposure increased litter size by 45% versus controls.
In plain wordsIn rats, maternal bromantan exposure increased litter size compared with controls.
Peptide
Bromantane
Outcome
IncreaseLitter size after maternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
150 mg/kg · oral · 15 daysAs given in this study (rat).
Measurements
Litter size increase
45%
maternal 150 mg/kg
Source sentences
Summary
In distinction, in the case of experimental females given 30 and 600 mg/kg bromantan before copulation (series II) the number of young rats in the litter insignificantly reduced (by 34.9 and 44.2%), in the case of rats given 150 mg/kg bromantan the litter increased (by 45%, p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052607
08AnimalAnimal study (in vivo)Safety outcome
In rat offspring, parental bromantan exposure increased first-week mean weight versus controls in both mating series.
In plain wordsIn rats, offspring of bromantan-treated parents weighed more than controls during the first week.
Peptide
Bromantane
Outcome
IncreaseFirst-week offspring weight
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
Both in series I and series II the mean weight of the newborns in the first week was significantly higher than the weight of the controls.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052608
09AnimalAnimal study (in vivo)Safety outcome
In rat offspring, subsequent body-weight growth was nonsignificantly slower after parental bromantan exposure versus controls.
In plain wordsIn rats, offspring weight gain after parental bromantan exposure was not significantly slower than controls after the first week.
Peptide
Bromantane
Outcome
No significant changeLater offspring weight gain
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
After that the growth in body weight was insignificantly slower.
2 context sentences(design, population, supporting numbers)
Summary · context
Both in series I and series II the mean weight of the newborns in the first week was significantly higher than the weight of the controls.
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052609
10AnimalAnimal study (in vivo)Safety outcome
In rat offspring, parental bromantan exposure nonsignificantly accelerated sensorimotor reflex maturation versus controls.
In plain wordsIn rats, offspring sensorimotor reflexes did not mature significantly faster than controls after parental bromantan exposure.
Peptide
Bromantane
Outcome
No significant changeSensorimotor maturation
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Development and maturation · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
Evaluation of the functional condition of the nervous system and terms of physical development of the progeny in series I and II of copulation showed an insignificant increase in the rate of maturation of the sensorimotor reflexes and physical parameters of the young experimental rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052610
11AnimalAnimal study (in vivo)Safety outcome
In rat offspring, parental bromantan exposure nonsignificantly accelerated physical maturation versus controls.
In plain wordsIn rats, offspring physical development did not accelerate significantly compared with controls after parental bromantan exposure.
Peptide
Bromantane
Outcome
No significant changePhysical maturation
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Development and maturation · Whole body
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
Evaluation of the functional condition of the nervous system and terms of physical development of the progeny in series I and II of copulation showed an insignificant increase in the rate of maturation of the sensorimotor reflexes and physical parameters of the young experimental rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052611
12AnimalAnimal study (in vivo)Safety outcome
In rat offspring, paternal bromantan exposure increased motor activity versus controls at the open-field assessment.
In plain wordsIn rats, offspring of bromantan-treated fathers showed more motor activity than controls.
Peptide
Bromantane
Outcome
IncreaseOffspring motor activity after paternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Measurements
Motor activity increase
8 to 21.6%
series I offspring
Source sentences
Summary
The "open-field" test conducted on the 40th day of life showed increase of motor (by 8.0-21.6%) and exploration activity (by 94.5-109.9%, p < 0.05) in the young experimental rats of series I and, at the same time, decrease of the grooming parameters (by 26.9-63.5%, p < 0.05) and emotionality.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052612
13AnimalAnimal study (in vivo)Safety outcome
In rat offspring, paternal bromantan exposure increased exploration versus controls at the open-field assessment.
In plain wordsIn rats, offspring of bromantan-treated fathers explored more than controls.
Peptide
Bromantane
Outcome
IncreaseOffspring exploration after paternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Measurements
Exploration increase
94.5 to 109.9%
series I offspring
Source sentences
Summary
The "open-field" test conducted on the 40th day of life showed increase of motor (by 8.0-21.6%) and exploration activity (by 94.5-109.9%, p < 0.05) in the young experimental rats of series I and, at the same time, decrease of the grooming parameters (by 26.9-63.5%, p < 0.05) and emotionality.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052613
14AnimalAnimal study (in vivo)Safety outcome
In rat offspring, paternal bromantan exposure reduced grooming versus controls at the open-field assessment.
In plain wordsIn rats, offspring of bromantan-treated fathers groomed less than controls.
Peptide
Bromantane
Outcome
DecreaseOffspring grooming after paternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Measurements
Grooming reduction
26.9 to 63.5%
series I offspring
Source sentences
Summary
The "open-field" test conducted on the 40th day of life showed increase of motor (by 8.0-21.6%) and exploration activity (by 94.5-109.9%, p < 0.05) in the young experimental rats of series I and, at the same time, decrease of the grooming parameters (by 26.9-63.5%, p < 0.05) and emotionality.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052614
15AnimalAnimal study (in vivo)Safety outcome
In rat offspring, paternal bromantan exposure reduced emotionality versus controls at the open-field assessment.
In plain wordsIn rats, offspring of bromantan-treated fathers showed less emotionality than controls.
Peptide
Bromantane
Outcome
DecreaseOffspring emotionality after paternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
The "open-field" test conducted on the 40th day of life showed increase of motor (by 8.0-21.6%) and exploration activity (by 94.5-109.9%, p < 0.05) in the young experimental rats of series I and, at the same time, decrease of the grooming parameters (by 26.9-63.5%, p < 0.05) and emotionality.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052615
16AnimalAnimal study (in vivo)Safety outcome
In rat offspring, maternal bromantan exposure reduced horizontal motor activity in all experimental groups.
In plain wordsIn rats, offspring of bromantan-treated mothers showed less horizontal motor activity than controls.
Peptide
Bromantane
Outcome
DecreaseOffspring horizontal motor activity after maternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
In all experimental groups of series II horizontal and vertical motor and searching activity was reduced.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052616
17AnimalAnimal study (in vivo)Safety outcome
In rat offspring, maternal bromantan exposure reduced vertical motor activity in all experimental groups.
In plain wordsIn rats, offspring of bromantan-treated mothers showed less vertical motor activity than controls.
Peptide
Bromantane
Outcome
DecreaseOffspring vertical motor activity after maternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
In all experimental groups of series II horizontal and vertical motor and searching activity was reduced.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052617
18AnimalAnimal study (in vivo)Safety outcome
In rat offspring, maternal bromantan exposure reduced searching activity in all experimental groups.
In plain wordsIn rats, offspring of bromantan-treated mothers showed less searching activity than controls.
Peptide
Bromantane
Outcome
DecreaseOffspring searching activity after maternal exposure
Study
ratn: not reported in source
Comparator
Controls
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · oralAs given in this study (rat).
Source sentences
Summary
In all experimental groups of series II horizontal and vertical motor and searching activity was reduced.
1 context sentence(design, population, supporting numbers)
Summary · context
The experiments were subdivided into two series: in series I the progeny obtained from coupling of experimental males with intact females was studied, in series II the progeny of intact males and experimental females.
Report a problemFND-1065052618

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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