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Study · Animal study (in vivo) · rat · 2000

7 results

[Effect of the long term administration of bromantan on the reproductive function in rats].

Khamidova TV, Bugaeva LI, Morozov IS, Spasov AA

Eksperimental'naia i klinicheskaia farmakologiia1 May 2000Cited by 4 (Europe PMC)

PMID10934594 (opens in a new tab)PepBankPUB-10934594
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In male rats, bromantan produced an unreliable decrease in absolute sperm amount.

    In plain wordsIn male rats, bromantan produced an unreliable decrease in sperm amount.

    Peptide
    Bromantane
    Outcome
    No significant changeSperm amount
    Study

    ratn: not reported in source

    rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    30 mg/kg daily · 2 monthsAs given in this study (rat).

    Source sentences

    Summary
    It was found that bromantan (30 mg/kg) unreliably decreases the absolute amount of sperm in males.
    1 context sentence
    Summary · context
    The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In female rats, bromantan did not affect the ovary weight coefficient during treatment.

    In plain wordsIn female rats, bromantan did not affect the ovary weight coefficient during treatment.

    Peptide
    Bromantane
    Outcome
    No significant changeOvary weight coefficient during treatment
    Study

    ratn: not reported in source

    rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    30 and 200 mg/kg daily · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    In females, the drug did not affect the ovary weight coefficient and increased the gestation index.
    1 context sentence
    Summary · context
    The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In female rats, bromantan increased the gestation index.

    In plain wordsIn female rats, bromantan increased the gestation index.

    Peptide
    Bromantane
    Outcome
    IncreaseGestation index
    Study

    ratn: not reported in source

    rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    30 and 200 mg/kg daily · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    In females, the drug did not affect the ovary weight coefficient and increased the gestation index.
    1 context sentence
    Summary · context
    The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In female rats, the ovary weight coefficient increased after bromantan administration ended.

    In plain wordsIn female rats, the ovary weight coefficient increased after bromantan administration ended.

    Peptide
    Bromantane
    Outcome
    IncreaseOvary weight coefficient after treatment
    Study

    ratn: not reported in source

    rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    30 and 200 mg/kg daily · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    After termination of the drug administration, the ovary weight coefficient increased.
    1 context sentence
    Summary · context
    The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In rats, bromantan did not affect the fertilizing capacity of male gametes.

    In plain wordsIn rats, bromantan did not affect the fertilizing capacity of male gametes.

    Peptide
    Bromantane
    Outcome
    No significant changeMale gamete fertilizing capacity
    Study

    ratn: not reported in source

    rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    30 and 200 mg/kg daily · 2 monthsAs given in this study (rat).

    Source sentences

    Summary
    Bromantan affected neither the fertilizing capacity of male and female gametes nor the embryonal characteristics of the breed.
    1 context sentence
    Summary · context
    The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In rats, bromantan did not affect the fertilizing capacity of female gametes.

    In plain wordsIn rats, bromantan did not affect the fertilizing capacity of female gametes.

    Peptide
    Bromantane
    Outcome
    No significant changeFemale gamete fertilizing capacity
    Study

    ratn: not reported in source

    rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    30 and 200 mg/kg daily · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bromantan affected neither the fertilizing capacity of male and female gametes nor the embryonal characteristics of the breed.
    1 context sentence
    Summary · context
    The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In rats, bromantan did not affect embryonal characteristics of the offspring.

    In plain wordsIn rats, bromantan did not affect embryonal characteristics of the offspring.

    Peptide
    Bromantane
    Outcome
    No significant changeEmbryonal characteristics
    Study

    ratn: not reported in source

    rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    30 and 200 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    Bromantan affected neither the fertilizing capacity of male and female gametes nor the embryonal characteristics of the breed.
    1 context sentence
    Summary · context
    The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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