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Study · Animal study (in vivo) · mouse · 2014

4 results

Correcting effect of ladasten on variations in the subpopulation composition of T lymphocytes in C57BL/6 mice on the experimental model of an anxious-depressive state.

Tallerova AV, Kovalenko LP, Kuznetsova OS, Durnev AD, Durnev AD, Seredenin SB

Bulletin of experimental biology and medicine16 Jan 2014Cited by 3 (Europe PMC)

PMID24771370 (opens in a new tab)DOI10.1007/s10517-014-2343-1 (opens in a new tab)PepBankPUB-24771370
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In stressed mice, Ladasten normalized relative thymus weight to the control level after stress-associated reduction.

    In plain wordsIn mice under stress, Ladasten restored relative thymus weight to the control level.

    Peptide
    Bromantane
    Outcome
    IncreaseRelative thymus weight
    Study

    mousen: not reported in source

    male C57Bl/6 mice with chronic zoosocial stress
    Comparator
    control level
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
    2 context sentences
    Summary · context
    Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4(+)/CD8(+) ratio toward cytotoxic T cells.
    Summary · context
    We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In stressed mice, Ladasten normalized relative spleen weight to the control level after stress-associated enlargement.

    In plain wordsIn mice under stress, Ladasten restored relative spleen weight to the control level.

    Peptide
    Bromantane
    Outcome
    DecreaseRelative spleen weight
    Study

    mousen: not reported in source

    male C57Bl/6 mice with chronic zoosocial stress
    Comparator
    control level
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
    2 context sentences
    Summary · context
    Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4(+)/CD8(+) ratio toward cytotoxic T cells.
    Summary · context
    We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In stressed mice, Ladasten restored the reduced percentage of T-cell populations in immunocompetent organs to the control level.

    In plain wordsIn stressed mice, Ladasten restored the percentage of T-cell populations in immune organs to the control level.

    Peptide
    Bromantane
    Outcome
    IncreaseT-cell population percentage
    Study

    mousen: not reported in source

    male C57Bl/6 mice with chronic zoosocial stress
    Comparator
    control level
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
    2 context sentences
    Summary · context
    Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4(+)/CD8(+) ratio toward cytotoxic T cells.
    Summary · context
    We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In stressed mice, Ladasten normalized T-cell subpopulation composition, including the CD4(+)/CD8(+) ratio shifted toward cytotoxic T cells by stress.

    In plain wordsIn stressed mice, Ladasten restored the balance of T-cell subpopulations to the control level.

    Peptide
    Bromantane
    Outcome
    Direction not reportedCD4(+)/CD8(+) ratio
    Study

    mousen: not reported in source

    male C57Bl/6 mice with chronic zoosocial stress
    Comparator
    control level
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 mg/kg · intraperitoneal · 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
    2 context sentences
    Summary · context
    Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4(+)/CD8(+) ratio toward cytotoxic T cells.
    Summary · context
    We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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