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Study · Animal study (in vivo) · rat · 2001

33 results

Effects of bromantan on offspring maturation and development of reflexes.

Iezhitsa IN, Spasov AA, Bugaeva LI

Neurotoxicology and teratology1 Mar 2001Cited by 14 (Europe PMC)

PMID11348840 (opens in a new tab)DOI10.1016/s0892-0362(01)00119-2 (opens in a new tab)PepBankPUB-11348840
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study33

30 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rat dams, general state did not differ significantly across groups during or after bromantan treatment.

    In plain wordsIn rats, maternal general state did not differ significantly from controls during or after bromantan treatment.

    Peptide
    Bromantane
    Outcome
    No significant changeMaternal general state
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Observation of rat dams revealed that their general state and activity in all groups did not differ significantly both during and after bromantan treatment.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rat dams, activity did not differ significantly across groups during or after bromantan treatment.

    In plain wordsIn rats, maternal activity did not differ significantly from controls during or after bromantan treatment.

    Peptide
    Bromantane
    Outcome
    No significant changeMaternal activity
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Observation of rat dams revealed that their general state and activity in all groups did not differ significantly both during and after bromantan treatment.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In rat dams, bromantan had no adverse effect on body weight.

    In plain wordsIn rats, bromantan had no adverse effect on maternal body weight.

    Peptide
    Bromantane
    Outcome
    No significant changeMaternal body weight
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Bromantan had no adverse effects on body weight and gestation length of dams.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rat dams, bromantan had no adverse effect on gestation length.

    In plain wordsIn rats, bromantan had no adverse effect on gestation length.

    Peptide
    Bromantane
    Outcome
    No significant changeGestation length
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Bromantan had no adverse effects on body weight and gestation length of dams.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In rats, the number of bromantan-exposed dams delivering did not differ from controls.

    In plain wordsIn rats, the number of mothers delivering after bromantan did not differ from controls.

    Peptide
    Bromantane
    Outcome
    No significant changeDams delivering
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Number of dams delivered per group did not differ from controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    Stillborn rat pups occurred in all litters, with fewer in controls than in bromantan groups.

    In plain wordsIn rats, stillbirths occurred in all litters, but controls had fewer than bromantan groups.

    Peptide
    Bromantane
    Outcome
    IncreaseStillbirths
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    There were stillborn rat pups in all litters, but the control group had less.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    One dam in the first bromantan group delivered a rat pup with a head hematoma.

    In plain wordsIn rats, one mother in the first bromantan group delivered a pup with a head hematoma.

    Peptide
    Bromantane
    Outcome
    Not applicableHead hematoma
    Study

    ratn: not reported in source

    female rats and their offspring
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    One dam in the first group delivered a rat pup with a head hematoma.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  8. 08AnimalAnimal study (in vivo)Safety outcome

    In rats, maternal bromantan at the low dose reduced litter size compared with controls.

    In plain wordsIn rats, low-dose maternal bromantan reduced litter size compared with controls.

    Peptide
    Bromantane
    Outcome
    DecreaseLitter size at low dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Litter size decrease
    34.9%
    30-mg/kg group

    Source sentences

    Summary
    Litter size of the 30- and 600-mg/kg groups was decreased (by 34.9% and 44.2%, respectively) and increased in the 150-mg/kg group (by 45.1%, P< .05) in comparison with controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  9. 09AnimalAnimal study (in vivo)Safety outcome

    In rats, maternal bromantan at the intermediate dose increased litter size compared with controls.

    In plain wordsIn rats, intermediate-dose maternal bromantan increased litter size compared with controls.

    Peptide
    Bromantane
    Outcome
    IncreaseLitter size at intermediate dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    150 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Litter size increase
    45.1%
    150-mg/kg group

    Source sentences

    Summary
    Litter size of the 30- and 600-mg/kg groups was decreased (by 34.9% and 44.2%, respectively) and increased in the 150-mg/kg group (by 45.1%, P< .05) in comparison with controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  10. 10AnimalAnimal study (in vivo)Safety outcome

    In rats, maternal bromantan at the high dose reduced litter size compared with controls.

    In plain wordsIn rats, high-dose maternal bromantan reduced litter size compared with controls.

    Peptide
    Bromantane
    Outcome
    DecreaseLitter size at high dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    600 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Litter size decrease
    44.2%
    600-mg/kg group

    Source sentences

    Summary
    Litter size of the 30- and 600-mg/kg groups was decreased (by 34.9% and 44.2%, respectively) and increased in the 150-mg/kg group (by 45.1%, P< .05) in comparison with controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  11. 11AnimalAnimal study (in vivo)Safety outcome

    In rats, bromantan effects on newborn sex ratio were insignificant in all treatment groups.

    In plain wordsIn rats, newborn sex ratios did not differ significantly between bromantan groups and controls.

    Peptide
    Bromantane
    Outcome
    No significant changeNewborn sex ratio
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Bromantan had insignificant different effects on the sex ratio of newborn in all treatment groups.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  12. 12AnimalAnimal study (in vivo)Safety outcome

    Rat pups after intermediate-dose maternal bromantan had greater mortality over the first 3 months than controls.

    In plain wordsIn rats, pups after intermediate-dose maternal bromantan had greater mortality over the first 3 months than controls.

    Peptide
    Bromantane
    Outcome
    IncreasePup mortality during early months
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    150 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Pup loss
    40%
    150-mg/kg group
    Pup loss
    20%
    controls

    Source sentences

    Summary
    Survival of pups over the first 3 months showed a loss of 40% for the 150-mg/kg group and 20% for controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  13. 13AnimalAnimal study (in vivo)Safety outcome

    In rat pups, later death rates after maternal bromantan did not differ from controls.

    In plain wordsIn rats, later pup death rates after maternal bromantan did not differ from controls.

    Peptide
    Bromantane
    Outcome
    No significant changeLater pup mortality
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Measurements

    Death rate
    3 to 6%
    remaining observation time; did not exceed

    Source sentences

    Summary
    During the remaining time, death rate did not exceed 3-6% and did not differ from those of the controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  14. 14AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan at 30 mg/kg had greater weight gain than controls through PND 35 and again at PND 77-112.

    In plain wordsIn rats, pups after maternal bromantan gained more weight than controls through postnatal day 35 and again on days 77-112.

    Peptide
    Bromantane
    Outcome
    IncreasePup weight gain after low maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Weight gain increase
    83.69%
    first week; 30-mg/kg group

    Source sentences

    Summary
    Pups in the 30- and 600-mg/kg groups showed significantly higher weight gain during the first week (7th PND) of observation by 83.69% and 58.02%, respectively, compared to controls; subsequently, this difference in the 600-mg/kg group decreased rapidly to insignificant levels, but the 30-mg/kg group…
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  15. 15AnimalAnimal study (in vivo)Safety outcome

    Rat pups after high-dose maternal bromantan had greater first-week weight gain than controls, followed by insignificant differences.

    In plain wordsIn rats, pups after high-dose maternal bromantan initially gained more weight than controls, but this difference became insignificant.

    Peptide
    Bromantane
    Outcome
    MixedPup weight gain after high maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    600 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Weight gain increase
    58.02%
    first week; 600-mg/kg group

    Source sentences

    Summary
    Pups in the 30- and 600-mg/kg groups showed significantly higher weight gain during the first week (7th PND) of observation by 83.69% and 58.02%, respectively, compared to controls; subsequently, this difference in the 600-mg/kg group decreased rapidly to insignificant levels, but the 30-mg/kg group…
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  16. 16AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan at 150 mg/kg gained less weight than controls except on PND 7, significantly on PNDs 14, 42 and 49.

    In plain wordsIn rats, exposed pups generally gained less weight than controls except on day 7, with significant differences on days 14, 42 and 49.

    Peptide
    Bromantane
    Outcome
    MixedPup weight gain after intermediate maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    150 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Dynamics of body weight gain of rat pups in the 150-mg/kg group during the whole (but not on PND 7) period of observation was insignificantly (on PNDs 14, 42 and 49 significantly) lower than that of the control group.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  17. 17AnimalAnimal study (in vivo)Safety outcome

    In rat pups, overall reflex expression after maternal bromantan differed insignificantly from controls.

    In plain wordsIn rats, overall pup reflex expression after maternal bromantan differed insignificantly from controls.

    Peptide
    Bromantane
    Outcome
    No significant changeOverall reflex expression
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Study of the functional state of rat pups' nervous system at different stages of postnatal development revealed insignificant differences in the expression of reflexes compared with those of the control group.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  18. 18AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan completed negative geotaxis earlier than controls, with significant differences only at 30 mg/kg.

    In plain wordsIn rats, pups after maternal bromantan completed negative geotaxis earlier than controls, with significant differences only at 30 mg/kg.

    Peptide
    Bromantane
    Outcome
    DecreaseNegative geotaxis development
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Measurements

    Earlier completion
    1 to 2 days
    treated groups

    Source sentences

    Summary
    Negative geotaxis was completed by the 8th day in controls and in treated groups earlier by an average of 1-2 days.
    3 context sentences
    Summary · context
    Significant differences were observed only for two parameters (negative geotaxis and surface righting); in both cases, rat pups of the 30-mg/kg group differed from the control and 150-mg/kg groups.
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  19. 19AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan at 30 mg/kg completed surface righting significantly earlier than controls.

    In plain wordsIn rats, pups after maternal bromantan at 30 mg/kg completed surface righting significantly earlier than controls.

    Peptide
    Bromantane
    Outcome
    DecreaseSurface righting at low maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Completion day
    6 day
    30-mg/kg group
    Completion day
    8 day
    controls

    Source sentences

    Summary
    Surface righting was completed by the controls on the 8th day, in the 30-mg/kg group on the 6th day and in other treated groups on the 7th day.
    3 context sentences
    Summary · context
    Significant differences were observed only for two parameters (negative geotaxis and surface righting); in both cases, rat pups of the 30-mg/kg group differed from the control and 150-mg/kg groups.
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  20. 20AnimalAnimal study (in vivo)Safety outcome

    Rat pups after other maternal bromantan doses completed surface righting earlier than controls.

    In plain wordsIn rats, pups after other maternal bromantan doses completed surface righting earlier than controls.

    Peptide
    Bromantane
    Outcome
    DecreaseSurface righting at other maternal doses
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    150 and 600 mg/kg · oral · 16 daysAs given in this study (rat).

    Measurements

    Completion day
    7 day
    other treated groups
    Completion day
    8 day
    controls

    Source sentences

    Summary
    Surface righting was completed by the controls on the 8th day, in the 30-mg/kg group on the 6th day and in other treated groups on the 7th day.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  21. 21AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan developed cliff avoidance a day earlier than controls.

    In plain wordsIn rats, pups after maternal bromantan developed cliff avoidance a day earlier than controls.

    Peptide
    Bromantane
    Outcome
    DecreaseCliff avoidance development
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Cliff avoidance appeared a day ahead for rat pups in treated groups compared with controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  22. 22AnimalAnimal study (in vivo)Safety outcome

    Rat pups after low or high maternal bromantan doses developed air righting a day earlier than controls.

    In plain wordsIn rats, pups after low or high maternal bromantan doses developed air righting a day earlier than controls.

    Peptide
    Bromantane
    Outcome
    DecreaseAir righting development
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30 and 600 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Air righting reflex in the 30- and 600-mg/kg groups was observed a day earlier than in the controls.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  23. 23AnimalAnimal study (in vivo)Safety outcome

    Rat pups in the low maternal bromantan group differed significantly in negative geotaxis from the intermediate-dose group.

    In plain wordsIn rats, pup negative geotaxis differed significantly between low and intermediate maternal bromantan doses.

    Peptide
    Bromantane
    Outcome
    Direction not reportedNegative geotaxis low versus intermediate dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    150-mg/kg group
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Significant differences were observed only for two parameters (negative geotaxis and surface righting); in both cases, rat pups of the 30-mg/kg group differed from the control and 150-mg/kg groups.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  24. 24AnimalAnimal study (in vivo)Safety outcome

    Rat pups in the low maternal bromantan group differed significantly in surface righting from the intermediate-dose group.

    In plain wordsIn rats, pup surface righting differed significantly between low and intermediate maternal bromantan doses.

    Peptide
    Bromantane
    Outcome
    DecreaseSurface righting low versus intermediate dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    150-mg/kg group
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Significant differences were observed only for two parameters (negative geotaxis and surface righting); in both cases, rat pups of the 30-mg/kg group differed from the control and 150-mg/kg groups.
    3 context sentences
    Summary · context
    Surface righting was completed by the controls on the 8th day, in the 30-mg/kg group on the 6th day and in other treated groups on the 7th day.
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  25. 25AnimalAnimal study (in vivo)Safety outcome

    Rat pups after low-dose maternal bromantan showed significantly earlier incisor eruption than controls.

    In plain wordsIn rats, pups after low-dose maternal bromantan showed significantly earlier incisor eruption than controls.

    Peptide
    Bromantane
    Outcome
    DecreaseIncisor eruption
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Development and maturation · Reproductive and sexual health
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Early development of physical parameters was also noted, but significant differences from the control group were obtained only in the 30-mg/kg group for incisor eruption.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  26. 26AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan increased grasp-maintenance times on PND 15.

    In plain wordsIn rats, pups after maternal bromantan increased grasp-maintenance times on PND 15.

    Peptide
    Bromantane
    Outcome
    IncreaseGrasp duration
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    While all pups demonstrated strength of fore and hind limbs by postnatal day 16, treated pups increased their times of maintaining their grasp (PND 15).
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  27. 27AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan showed an insignificant decrease in exploratory behavior compared with controls.

    In plain wordsIn rats, pup exploratory behavior after maternal bromantan was insignificantly lower than controls.

    Peptide
    Bromantane
    Outcome
    No significant changeExploratory behavior
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Open-field testing (PND 40) resulted in an insignificant decrease of exploratory and locomotor behaviors for the 30-, 150- and 600-mg/kg groups.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  28. 28AnimalAnimal study (in vivo)Safety outcome

    Rat pups after maternal bromantan showed an insignificant decrease in locomotor behavior compared with controls.

    In plain wordsIn rats, pup locomotor behavior after maternal bromantan was insignificantly lower than controls.

    Peptide
    Bromantane
    Outcome
    No significant changeLocomotor behavior
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    30, 150 and 600 mg/kg daily · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    Open-field testing (PND 40) resulted in an insignificant decrease of exploratory and locomotor behaviors for the 30-, 150- and 600-mg/kg groups.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  29. 29AnimalAnimal study (in vivo)Safety outcome

    Rat pups after low-dose maternal bromantan showed an insignificant decrease in grooming episodes.

    In plain wordsIn rats, pup grooming after low-dose maternal bromantan was insignificantly lower than in controls.

    Peptide
    Bromantane
    Outcome
    No significant changeGrooming after low maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    30 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    The number of grooming episodes was insignificantly decreased for the 30-mg/kg group and insignificantly increased for the 600-mg/kg group.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.
  30. 30AnimalAnimal study (in vivo)Safety outcome

    Rat pups after high-dose maternal bromantan showed an insignificant increase in grooming episodes.

    In plain wordsIn rats, pup grooming after high-dose maternal bromantan was insignificantly higher than in controls.

    Peptide
    Bromantane
    Outcome
    No significant changeGrooming after high maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Vehicle controls
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    600 mg/kg · oral · 16 daysAs given in this study (rat).

    Source sentences

    Summary
    The number of grooming episodes was insignificantly decreased for the 30-mg/kg group and insignificantly increased for the 600-mg/kg group.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.

Studies that did not test the peptide alone3

In this study, Bromantane was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Bromantane.

  1. 31AnimalNot a test of Bromantane aloneAnimal study (in vivo)Safety outcome

    In rat pups after low-dose maternal bromantan, passive avoidance entry latency increased significantly from training to retention, while controls also increased.

    In plain wordsIn rats, pup entry latency after maternal bromantan at 30 mg/kg increased significantly from training to retention, while controls also increased.

    Peptide
    Bromantane
    Outcome
    IncreasePassive avoidance latency after low maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Training day
    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Entry latency increase
    259 %
    30-mg/kg group
    Entry latency increase
    1.8%
    control group

    Source sentences

    Summary
    In the passive avoidance testing, on the retention day (72 h later), entry latency for rat pups in the 30-, 150- and 600-mg/kg groups increased by 259.0%, 175.3% and 160.7%, respectively (P< .05), over their training day, while in the control group, time increased only by 1.8%.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.

    In this study, Bromantane was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bromantane.

  2. 32AnimalNot a test of Bromantane aloneAnimal study (in vivo)Safety outcome

    In rat pups after intermediate-dose maternal bromantan, passive avoidance entry latency increased significantly from training to retention, while controls also increased.

    In plain wordsIn rats, pup entry latency after maternal bromantan at 150 mg/kg increased significantly from training to retention, while controls also increased.

    Peptide
    Bromantane
    Outcome
    IncreasePassive avoidance latency after intermediate maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Training day
    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Entry latency increase
    175.3 %
    150-mg/kg group
    Entry latency increase
    1.8%
    control group

    Source sentences

    Summary
    In the passive avoidance testing, on the retention day (72 h later), entry latency for rat pups in the 30-, 150- and 600-mg/kg groups increased by 259.0%, 175.3% and 160.7%, respectively (P< .05), over their training day, while in the control group, time increased only by 1.8%.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.

    In this study, Bromantane was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bromantane.

  3. 33AnimalNot a test of Bromantane aloneAnimal study (in vivo)Safety outcome

    In rat pups after high-dose maternal bromantan, passive avoidance entry latency increased significantly from training to retention, while controls also increased.

    In plain wordsIn rats, pup entry latency after maternal bromantan at 600 mg/kg increased significantly from training to retention, while controls also increased.

    Peptide
    Bromantane
    Outcome
    IncreasePassive avoidance latency after high maternal dose
    Study

    ratn: not reported in source

    female rats and their offspring
    Comparator
    Training day
    Outcome group
    Cognition and memory · Nervous system and cognition

    Measurements

    Entry latency increase
    160.7 %
    600-mg/kg group
    Entry latency increase
    1.8%
    control group

    Source sentences

    Summary
    In the passive avoidance testing, on the retention day (72 h later), entry latency for rat pups in the 30-, 150- and 600-mg/kg groups increased by 259.0%, 175.3% and 160.7%, respectively (P< .05), over their training day, while in the control group, time increased only by 1.8%.
    2 context sentences
    Summary · context
    Sexually mature female rats, weighing 180-200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution.
    Summary · context
    Afterwards, treated females were mated with untreated males.

    In this study, Bromantane was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Bromantane.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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