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Study · Animal study (in vivo) · mouse · 2014

3 results

Aerobic exercise increases tear secretion in type 2 diabetic mice.

Sano K, Kawashima M, Ito A, Inaba T, Morimoto K, Watanabe M, Tsubota K

Investigative ophthalmology & visual science29 May 2014Cited by 22 (Europe PMC)

PMID24876288 (opens in a new tab)DOI10.1167/iovs.13-13289 (opens in a new tab)PepBankPUB-24876288
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6JJc1 mice, AICAR at 125 mg/kg increased tear secretion volume compared with PBS.

    In plain wordsIn mice, AICAR at 125 mg/kg increased tear secretion compared with PBS.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseTear secretion volume
    Study

    mousen: not reported in source

    C57BL/6JJc1 mice
    Comparator
    PBS
    Outcome group
    Ocular surface · Eye
    Studied dose
    125 mg/kg · intraperitoneal injection · 5 daysAs given in this study (mouse).

    Measurements

    P value
    < 0.01
    AICAR 125 mg/kg versus PBS

    Source sentences

    Summary
    In C57BL/6JJc1 mice, the tear secretion volumes in both the AICAR 125 mg/kg and AICAR 250 mg/kg groups were significantly larger than in the PBS group (P < 0.01 and P < 0.01, respectively).
    1 context sentence
    Summary · context
    Furthermore, C57BL/6JJc1 mice, db/db mice, and db/m mice received a single intraperitoneal injection of AICAR or PBS each day for 5 days, and tear secretion volume was measured.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6JJc1 mice, AICAR at 250 mg/kg increased tear secretion volume compared with PBS.

    In plain wordsIn mice, AICAR at 250 mg/kg increased tear secretion compared with PBS.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseTear secretion volume
    Study

    mousen: not reported in source

    C57BL/6JJc1 mice
    Comparator
    PBS
    Outcome group
    Ocular surface · Eye
    Studied dose
    250 mg/kg · intraperitoneal injection · 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    In C57BL/6JJc1 mice, the tear secretion volumes in both the AICAR 125 mg/kg and AICAR 250 mg/kg groups were significantly larger than in the PBS group (P < 0.01 and P < 0.01, respectively).
    1 context sentence
    Summary · context
    Furthermore, C57BL/6JJc1 mice, db/db mice, and db/m mice received a single intraperitoneal injection of AICAR or PBS each day for 5 days, and tear secretion volume was measured.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic db/db mice, AICAR at 125 mg/kg increased tear secretion volume compared with PBS.

    In plain wordsIn diabetic mice, AICAR at 125 mg/kg increased tear secretion compared with PBS.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseTear secretion volume
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    PBS
    Outcome group
    Ocular surface · Eye
    Studied dose
    125 mg/kg · intraperitoneal injection · 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, in db/db mice, tear secretion volume in the AICAR 125 mg/kg group was also significantly larger than in the PBS group (P < 0.05).
    1 context sentence
    Summary · context
    Furthermore, C57BL/6JJc1 mice, db/db mice, and db/m mice received a single intraperitoneal injection of AICAR or PBS each day for 5 days, and tear secretion volume was measured.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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