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Study · Animal study (in vivo) · mouse · 2020

5 results

AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow.

Lane SL, Houck JA, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG

The Journal of physiology6 Jul 2020Cited by 29 (Europe PMC)

PMID32592403 (opens in a new tab)PMCIDPMC7749723 (opens in a new tab)DOI10.1113/jp279341 (opens in a new tab)PepBankPUB-32592403
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypoxic pregnant mice, AICAR partially prevented fetal growth restriction.

    In plain wordsIn hypoxic pregnant mice, AICAR partially prevented restricted fetal growth compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseFetal growth restriction
    Study

    mousen: not reported in source

    hypoxic pregnancy in C57Bl/6 mice
    Comparator
    vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 mg kg-1 day-1 · subcutaneous pelletAs given in this study (mouse).

    Source sentences

    Summary
    Pharmacological AMPK activation by AICAR partially prevented hypoxia-induced fetal growth restriction (P < 0.01), due in part to increased uterine artery blood flow (P < 0.0001).
    1 context sentence
    Summary · context
    In this study, C57Bl/6 mice were treated with subcutaneous pellets containing vehicle, the AMPK activator AICAR (200 mg kg-1 day-1 ), or the AMPK inhibitor Compound C (20 mg kg-1 day-1 ) beginning on gestational day 13.5, and were exposed to hypoxia starti…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypoxic pregnant mice, AICAR increased uterine artery blood flow.

    In plain wordsIn hypoxic pregnant mice, AICAR increased uterine artery blood flow compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseUterine artery blood flow
    Study

    mousen: not reported in source

    hypoxic pregnancy in C57Bl/6 mice
    Comparator
    vehicle
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    200 mg kg-1 day-1 · subcutaneous pelletAs given in this study (mouse).

    Source sentences

    Summary
    Pharmacological AMPK activation by AICAR partially prevented hypoxia-induced fetal growth restriction (P < 0.01), due in part to increased uterine artery blood flow (P < 0.0001).
    1 context sentence
    Summary · context
    In this study, C57Bl/6 mice were treated with subcutaneous pellets containing vehicle, the AMPK activator AICAR (200 mg kg-1 day-1 ), or the AMPK inhibitor Compound C (20 mg kg-1 day-1 ) beginning on gestational day 13.5, and were exposed to hypoxia starti…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hypoxic mice, AICAR increased the proportion of cardiac output flowing through the uterine artery.

    In plain wordsIn hypoxic mice, AICAR increased the share of cardiac output reaching the uterine artery compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCardiac output proportion through uterine artery
    Study

    mousen: not reported in source

    hypoxic pregnancy in C57Bl/6 mice
    Comparator
    vehicle
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    200 mg kg-1 day-1 · subcutaneous pelletAs given in this study (mouse).

    Source sentences

    Summary
    The proportion of total cardiac output flowing through the uterine artery was increased with AICAR in hypoxic mice (P < 0.001), suggesting that the vasodilator effect of AICAR was selective for the uterine circulation.
    1 context sentence
    Summary · context
    In this study, C57Bl/6 mice were treated with subcutaneous pellets containing vehicle, the AMPK activator AICAR (200 mg kg-1 day-1 ), or the AMPK inhibitor Compound C (20 mg kg-1 day-1 ) beginning on gestational day 13.5, and were exposed to hypoxia starti…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In pregnant mice, AICAR increased uterine artery AMPK activation compared with vehicle.

    In plain wordsIn pregnant mice, AICAR increased AMPK activation in the uterine artery compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseUterine artery AMPK activation
    Study

    mousen: not reported in source

    hypoxic pregnancy in C57Bl/6 mice
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    200 mg kg-1 day-1 · subcutaneous pelletAs given in this study (mouse).

    Source sentences

    Summary
    Two-way ANOVA analyses indicated that hypoxia reduced AMPK activation in the uterine artery and placenta, and AICAR increased AMPK activation in these tissues compared to vehicle.
    1 context sentence
    Summary · context
    In this study, C57Bl/6 mice were treated with subcutaneous pellets containing vehicle, the AMPK activator AICAR (200 mg kg-1 day-1 ), or the AMPK inhibitor Compound C (20 mg kg-1 day-1 ) beginning on gestational day 13.5, and were exposed to hypoxia starti…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In pregnant mice, AICAR increased placental AMPK activation compared with vehicle.

    In plain wordsIn pregnant mice, AICAR increased AMPK activation in the placenta compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePlacental AMPK activation
    Study

    mousen: not reported in source

    hypoxic pregnancy in C57Bl/6 mice
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    200 mg kg-1 day-1 · subcutaneous pelletAs given in this study (mouse).

    Source sentences

    Summary
    Two-way ANOVA analyses indicated that hypoxia reduced AMPK activation in the uterine artery and placenta, and AICAR increased AMPK activation in these tissues compared to vehicle.
    1 context sentence
    Summary · context
    In this study, C57Bl/6 mice were treated with subcutaneous pellets containing vehicle, the AMPK activator AICAR (200 mg kg-1 day-1 ), or the AMPK inhibitor Compound C (20 mg kg-1 day-1 ) beginning on gestational day 13.5, and were exposed to hypoxia starti…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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