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Study · Animal study (in vivo) · daphnia pulex · 2012

2 results

Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling.

Sheng B, Liu J, Li GH

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology4 May 2012Cited by 32 (Europe PMC)

PMID22564403 (opens in a new tab)DOI10.1016/j.cbpb.2012.04.009 (opens in a new tab)PepBankPUB-22564403
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Daphnia pulex, AICAR failed to reproduce metformin's protective effect against hypoxic insult.

    In plain wordsIn Daphnia pulex, AICAR did not reproduce the protection against low oxygen seen with metformin.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedProtection against hypoxic insult
    Study

    Daphnia pulexn: not reported in source

    hypoxic insult
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, the AMPK agonist AICAR failed to mimic the protective effect of metformin.
    1 context sentence
    Summary · context
    In a freshwater invertebrate, Daphnia pulex, we found that preconditioning with the antidiabetic drug metformin protects the animals from hypoxic insult.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Daphnia pulex, AICAR alone failed to increase HIF gene expression.

    In plain wordsIn Daphnia pulex, AICAR alone did not increase HIF gene expression.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedHIF gene expression
    Study

    Daphnia pulexn: not reported in source

    hypoxic insult
    Outcome group
    Gene expression · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while AICAR treatment alone failed to increase the expression of HIF genes.
    1 context sentence
    Summary · context
    In a freshwater invertebrate, Daphnia pulex, we found that preconditioning with the antidiabetic drug metformin protects the animals from hypoxic insult.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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