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Study · Animal study (in vivo) · rat · 2011

10 results

Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside treatment increases the sirtuin 1 protein expression in skeletal muscle.

Suwa M, Nakano H, Radak Z, Kumagai S

Metabolism: clinical and experimental1 Apr 2010Cited by 25 (Europe PMC)

PMID20362304 (opens in a new tab)DOI10.1016/j.metabol.2010.03.003 (opens in a new tab)PepBankPUB-20362304
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased AMPK alpha-subunit phosphorylation in soleus and extensor digitorum longus muscles.

    In plain wordsIn rats, AICAR increased AMPK phosphorylation in both studied muscles.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK alpha-subunit phosphorylation
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The AICAR promoted the phosphorylation of AMPK α-subunit (Thr¹⁷²) and acetyl-coenzyme A carboxylase (Ser⁷⁹) without any change of total AMPK α-subunit or acetyl-coenzyme A carboxylase protein levels in both the slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased acetyl-coenzyme A carboxylase phosphorylation in soleus and extensor digitorum longus muscles.

    In plain wordsIn rats, AICAR increased acetyl-coenzyme A carboxylase phosphorylation in both studied muscles.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAcetyl-coenzyme A carboxylase phosphorylation
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The AICAR promoted the phosphorylation of AMPK α-subunit (Thr¹⁷²) and acetyl-coenzyme A carboxylase (Ser⁷⁹) without any change of total AMPK α-subunit or acetyl-coenzyme A carboxylase protein levels in both the slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR did not change total AMPK alpha-subunit protein in soleus or extensor digitorum longus muscles.

    In plain wordsIn rats, AICAR did not change total AMPK protein in either studied muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeTotal AMPK alpha-subunit protein
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The AICAR promoted the phosphorylation of AMPK α-subunit (Thr¹⁷²) and acetyl-coenzyme A carboxylase (Ser⁷⁹) without any change of total AMPK α-subunit or acetyl-coenzyme A carboxylase protein levels in both the slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR did not change total acetyl-coenzyme A carboxylase protein in either studied muscle.

    In plain wordsIn rats, AICAR did not change total acetyl-coenzyme A carboxylase protein in either studied muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeTotal acetyl-coenzyme A carboxylase protein
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The AICAR promoted the phosphorylation of AMPK α-subunit (Thr¹⁷²) and acetyl-coenzyme A carboxylase (Ser⁷⁹) without any change of total AMPK α-subunit or acetyl-coenzyme A carboxylase protein levels in both the slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased SIRT1 protein expression in extensor digitorum longus muscle at 24 hours.

    In plain wordsIn rats, AICAR increased SIRT1 protein in the fast-twitch muscle at 24 hours.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEDL SIRT1 protein expression
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The SIRT1 protein expression increased at 24 hours after administration of AICAR in the EDL muscle but not in the soleus muscle.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR did not increase SIRT1 protein expression in soleus muscle at 24 hours.

    In plain wordsIn rats, AICAR did not increase SIRT1 protein in soleus muscle at 24 hours.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeSoleus SIRT1 protein expression
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The SIRT1 protein expression increased at 24 hours after administration of AICAR in the EDL muscle but not in the soleus muscle.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased PGC-1α protein expression in soleus and extensor digitorum longus muscles at 24 hours.

    In plain wordsIn rats, AICAR increased PGC-1α protein in both studied muscles at 24 hours.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1alpha protein expression
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The PGC-1α protein expression increased in both the soleus and EDL muscles and GLUT4 did in the EDL muscle at 24 hours after an administration of AICAR.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased GLUT4 protein expression in extensor digitorum longus muscle at 24 hours.

    In plain wordsIn rats, AICAR increased GLUT4 protein in the fast-twitch muscle at 24 hours.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEDL GLUT4 protein expression
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The PGC-1α protein expression increased in both the soleus and EDL muscles and GLUT4 did in the EDL muscle at 24 hours after an administration of AICAR.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased soleus hexokinase activity at 18 and 24 hours.

    In plain wordsIn rats, AICAR increased soleus hexokinase activity at 18 and 24 hours.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSoleus hexokinase activity
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The hexokinase activity increased at 18 and 24 hours in the soleus and at 12, 18, and 24 hours in the EDL after an AICAR treatment.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased extensor digitorum longus hexokinase activity at 12, 18 and 24 hours.

    In plain wordsIn rats, AICAR increased hexokinase activity in the fast-twitch muscle at 12, 18 and 24 hours.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEDL hexokinase activity
    Study

    ratn: not reported in source

    Soleus and extensor digitorum longus muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The hexokinase activity increased at 18 and 24 hours in the soleus and at 12, 18, and 24 hours in the EDL after an AICAR treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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