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Study · Animal study (in vivo) · rat · 2013

11 results

AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat.

Banek CT, Bauer AJ, Needham KM, Dreyer HC, Gilbert JS

American journal of physiology. Heart and circulatory physiology15 Feb 2013Cited by 36 (Europe PMC)

PMID23417865 (opens in a new tab)PMCIDPMC3625906 (opens in a new tab)DOI10.1152/ajpheart.00903.2012 (opens in a new tab)PepBankPUB-23417865
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with RUPP, AICAR ameliorated hypertension versus RUPP alone.

    In plain wordsIn rats with RUPP, AICAR reduced hypertension versus RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHypertension
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    RUPP-induced hypertension was ameliorated (P < 0.05) with AICAR versus RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with RUPP, AICAR increased plasma VEGF versus RUPP alone.

    In plain wordsIn rats with RUPP, AICAR increased plasma VEGF versus RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePlasma VEGF
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    AICAR increased (P < 0.05) plasma VEGF and decreased (P < 0.05) plasma soluble VEGF receptor-1 in the RUPP + AICAR versus RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with RUPP, AICAR decreased plasma soluble VEGF receptor-1 versus RUPP alone.

    In plain wordsIn rats with RUPP, AICAR decreased plasma soluble VEGF receptor-1 versus RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseSoluble VEGF receptor-1
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    AICAR increased (P < 0.05) plasma VEGF and decreased (P < 0.05) plasma soluble VEGF receptor-1 in the RUPP + AICAR versus RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with RUPP, AICAR restored placental antioxidant capacity.

    In plain wordsIn rats with RUPP, AICAR restored placental antioxidant capacity compared with RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePlacental antioxidant capacity
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Antioxidant capacity was restored (P < 0.05) by AICAR in RUPP placenta.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with RUPP, AICAR decreased renal catalase activity versus RUPP alone.

    In plain wordsIn rats with RUPP, AICAR decreased kidney catalase activity versus RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseRenal catalase activity
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Renal and placental catalase activity was decreased (P < 0.05) in RUPP + AICAR versus RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with RUPP, AICAR decreased placental catalase activity versus RUPP alone.

    In plain wordsIn rats with RUPP, AICAR decreased placental catalase activity versus RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePlacental catalase activity
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Renal and placental catalase activity was decreased (P < 0.05) in RUPP + AICAR versus RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with RUPP, AICAR increased angiogenic potential versus RUPP alone.

    In plain wordsIn rats with RUPP, AICAR increased angiogenic potential versus RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAngiogenic potential
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Angiogenic potential was increased (P < 0.05) in RUPP + AICAR versus RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats, AICAR did not affect fetal weight.

    In plain wordsIn pregnant rats, AICAR did not affect fetal weight.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeFetal weight
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Outcome group
    Body weight · Reproductive and sexual health
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Fetal and placental weights were unaffected by AICAR.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats, AICAR did not affect placental weight.

    In plain wordsIn pregnant rats, AICAR did not affect placental weight.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changePlacental weight
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Outcome group
    Body weight · Reproductive and sexual health
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Fetal and placental weights were unaffected by AICAR.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In RUPP rats, AICAR increased placental AMPK phosphorylation versus normal pregnant rats.

    In plain wordsIn RUPP rats, AICAR increased placental AMPK phosphorylation versus normal pregnant rats.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePlacental AMPK phosphorylation
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    Normal pregnant rats
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Placental AMPK phosphorylation was increased (P < 0.05) in RUPP + AICAR versus normal pregnant and RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In RUPP rats, AICAR increased placental AMPK phosphorylation versus RUPP alone.

    In plain wordsIn RUPP rats, AICAR increased placental AMPK phosphorylation versus RUPP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePlacental AMPK phosphorylation
    Study

    ratn: not reported in source

    RUPP preeclampsia model
    Comparator
    RUPP
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    50 mg/kg b.i.d. · intraperitoneal · days 14-18 of gestationAs given in this study (rat).

    Source sentences

    Summary
    Placental AMPK phosphorylation was increased (P < 0.05) in RUPP + AICAR versus normal pregnant and RUPP.
    2 context sentences
    Summary · context
    In rats, reduced uteroplacental perfusion pressure (RUPP) was induced on day 14 of gestation by introducing silver clips on the inferior abdominal aorta and ovarian arteries.
    Summary · context
    AICAR was administered intraperitoneally (50 mg/kg b.i.d.) days 14-18, and blood pressure and tissues were collected on day 19.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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