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Study · Animal study (in vivo) · rat · 2021

3 results

Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats.

Cao XJ, Wu R, Qian HY, Chen X, Zhu HY, Xu GY, Sun YZ, Zhang PA

Brain research20 Sept 2021Cited by 30 (Europe PMC)

PMID34555415 (opens in a new tab)DOI10.1016/j.brainres.2021.147663 (opens in a new tab)PepBankPUB-34555415
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, AICAR activated AMPK.

    In plain wordsIn diabetic rats, AICAR activated AMPK.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK activation
    Study

    ratn: not reported in source

    diabetic rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecal injectionAs given in this study (rat).

    Source sentences

    Summary
    Intrathecal injection of AICAR (an AMPK agonist) could activate AMPK and alleviate the mechanical allodynia of diabetic rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, AICAR alleviated mechanical allodynia.

    In plain wordsIn diabetic rats, AICAR reduced mechanical pain sensitivity.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMechanical allodynia
    Study

    ratn: not reported in source

    diabetic rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecal injectionAs given in this study (rat).

    Source sentences

    Summary
    Intrathecal injection of AICAR (an AMPK agonist) could activate AMPK and alleviate the mechanical allodynia of diabetic rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, NF-κB regulation decreased when AICAR activated AMPK.

    In plain wordsIn diabetic rats, NF-κB regulation decreased when AICAR activated AMPK.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNF-κB regulation
    Study

    ratn: not reported in source

    diabetic rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecal injectionAs given in this study (rat).

    Source sentences

    Summary
    Interestingly, the regulation of NF-κB in diabetic rats was obviously reduced when AMPK was activated by AICAR.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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