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Study · Animal study (in vivo) · rat · 2013

5 results

In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated β-cell dysfunction during the progression of type-2 diabetes.

Kim JY, Park KJ, Kim GH, Jeong EA, Lee DY, Lee SS, Kim DJ, Roh GS, Song J, Ki SH, Kim WH

Cellular signalling2 Aug 2013Cited by 27 (Europe PMC)

PMID23916985 (opens in a new tab)DOI10.1016/j.cellsig.2013.07.028 (opens in a new tab)PepBankPUB-23916985
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In late-diabetic ZDF rats, chronic AICAR attenuated increases in lipogenic genes.

    In plain wordsIn rats with late diabetes, chronic AICAR reduced increases in lipogenic genes.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLipogenic gene increases
    Study

    ratn: not reported in source

    Zucker diabetic fatty rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · chronicAs given in this study (rat).

    Source sentences

    Summary
    Although AMPK phosphorylation reduced in 6- and 12-week-old ZDF rats was remarkably increased at 19weeks, the increases of lipogenice genes, ATF3, and ER stress or ROS-mediated β-cell dysfunction were still remained, which were attenuated by in vivo-injection of chemical chaperon tauroursodeoxychola…
    1 context sentence
    Summary · context
    Here, we investigated the role of ATF3 on the preventive regulation of AMPK against ER stress-mediated β-cell dysfunction during the end-stage progression of hyperglycemia in ZDF rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In late-diabetic ZDF rats, chronic AICAR attenuated increases in ATF3.

    In plain wordsIn rats with late diabetes, chronic AICAR reduced increases in ATF3.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseATF3 increases
    Study

    ratn: not reported in source

    Zucker diabetic fatty rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · chronicAs given in this study (rat).

    Source sentences

    Summary
    Although AMPK phosphorylation reduced in 6- and 12-week-old ZDF rats was remarkably increased at 19weeks, the increases of lipogenice genes, ATF3, and ER stress or ROS-mediated β-cell dysfunction were still remained, which were attenuated by in vivo-injection of chemical chaperon tauroursodeoxychola…
    1 context sentence
    Summary · context
    Here, we investigated the role of ATF3 on the preventive regulation of AMPK against ER stress-mediated β-cell dysfunction during the end-stage progression of hyperglycemia in ZDF rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In late-diabetic ZDF rats, chronic AICAR attenuated ER stress or ROS-mediated β-cell dysfunction.

    In plain wordsIn rats with late diabetes, chronic AICAR reduced pancreatic cell dysfunction linked to ER stress or reactive oxygen species.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseER stress or ROS-mediated β-cell dysfunction
    Study

    ratn: not reported in source

    Zucker diabetic fatty rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · chronicAs given in this study (rat).

    Source sentences

    Summary
    Although AMPK phosphorylation reduced in 6- and 12-week-old ZDF rats was remarkably increased at 19weeks, the increases of lipogenice genes, ATF3, and ER stress or ROS-mediated β-cell dysfunction were still remained, which were attenuated by in vivo-injection of chemical chaperon tauroursodeoxychola…
    1 context sentence
    Summary · context
    Here, we investigated the role of ATF3 on the preventive regulation of AMPK against ER stress-mediated β-cell dysfunction during the end-stage progression of hyperglycemia in ZDF rats.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ZDF rats, ATF3 siRNA knockdown enhanced the beneficial effect of AICAR.

    In plain wordsIn rats with diabetes, ATF3 gene silencing enhanced AICAR's beneficial effect.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAICAR benefit after ATF3 knockdown
    Study

    ratn: not reported in source

    Zucker diabetic fatty rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    Moreover, knockdown of ATF3 by delivery of in vivo-jetPEI ATF3 siRNA attenuated ER stress-mediated β-cell dysfunction and enhanced the beneficial effect of AICAR.
    1 context sentence
    Summary · context
    Here, we investigated the role of ATF3 on the preventive regulation of AMPK against ER stress-mediated β-cell dysfunction during the end-stage progression of hyperglycemia in ZDF rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ZDF rats, ATF3 siRNA delivery attenuated ER stress-mediated β-cell dysfunction.

    In plain wordsIn rats with diabetes, ATF3 gene silencing reduced pancreatic cell dysfunction linked to ER stress.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseER stress-mediated β-cell dysfunction after ATF3 knockdown
    Study

    ratn: not reported in source

    Zucker diabetic fatty rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    Moreover, knockdown of ATF3 by delivery of in vivo-jetPEI ATF3 siRNA attenuated ER stress-mediated β-cell dysfunction and enhanced the beneficial effect of AICAR.
    1 context sentence
    Summary · context
    Here, we investigated the role of ATF3 on the preventive regulation of AMPK against ER stress-mediated β-cell dysfunction during the end-stage progression of hyperglycemia in ZDF rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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